GABA Modulators
GABA modulators are compounds that influence the function of GABA (gamma-aminobutyric acid) receptors, the primary inhibitory neurotransmitter receptors in the central nervous system. These modulators can either enhance or inhibit GABAergic activity, affecting neuronal excitability and synaptic transmission. GABA modulators are crucial in the treatment and study of various neurological and psychiatric disorders, including anxiety, epilepsy, and insomnia. At CymitQuimica, we offer a wide range of GABA modulators to support your research in neuroscience, pharmacology, and neurotherapeutics.
Products of "GABA Modulators"
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4-Boc-7-Hydroxy-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS:Purity:97.0%Molecular weight:264.32501220703125Clobazam-13C6
CAS:Controlled ProductApplications Clobazam-13C6 is the isotope labelled analog of Clobazam (C582500); a benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic and anticonvulsant. Controlled substance (depressant). References Gastaut, H., et al.: Epilepsia, 20, 437 (1979); Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990); Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)Formula:C6C10H13ClN2O2Color and Shape:Off-WhiteMolecular weight:306.70Barbital
CAS:Controlled ProductApplications Prototype of the barbiturate hypnotics. References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009), Yu, J., et al.: Pharm. Res., 27, 457 (2010), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),Formula:C8H12N2O3Color and Shape:NeatMolecular weight:184.194-Hydroxy Estazolam
CAS:Controlled ProductApplications A metabolite of Estazolam (E668380). Controlled Substance. References Gorski, J., et al.: Xenobiotica, 1999, 29, 931, Hesse, L., et al.: Drug Metab. Dispos., 29, 133 (2001),Formula:C16H11ClN4OColor and Shape:White To Off WhiteMolecular weight:310.74Alprazolam 5-Oxide
CAS:Controlled ProductApplications A metabolite of Alprazolam (A575650). References Schwartz, M.A., et al.: J. Pharmacol. Exp. Ther., 149, 423 (1965), Childress, S.J., et al.: J. Pharm. Sci., 53, 577 (1964), Gall, M., et al.: J. Med. Chem., 21, 1290 (1978)Formula:C17H13ClN4OColor and Shape:NeatMolecular weight:324.765-Ethyl-5-(1-ethylpropyl)-2-thiobarbituric Acid-d5
CAS:Controlled ProductFormula:C11D5H13N2O2SColor and Shape:NeatMolecular weight:247.3697-Bromo-2,3,4,5-tetrahydro-1h-1,4-benzodiazepin-5-one
CAS:Purity:95+%Molecular weight:241.08799743652344Haloxazolam
CAS:Controlled ProductApplications Sleep-inducing agent, related structurally to Oxazolam and Cloxazolam (C587475). Sedative, hypnotic. Controlled substance (depressant). References Miyadera, T., et al.: J. Med. Chem., 14, 520, (1971), Yoshimoto, M., et al.: Chem. Pharm. Bull., 25, 1378 (1977),Formula:C17H14BrFN2O2Color and Shape:NeatMolecular weight:377.21Prazepam-d5
CAS:Controlled ProductApplications Prazepam-d5, is the labeled analogue of Prazepam (P702250), a benzodiazepine derivative drug having anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. References Shader R. I., et al.: Ciba. Found. Symp., (74), 141 (1979); Jacqmin, P., et al.: Neuropsychobiology, 19 (4), 186 (1988);Formula:C192H5H12ClN2OColor and Shape:NeatMolecular weight:329.83Desalkylflurazepam (7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one)
CAS:Formula:C15H10ClFN2OBromazepam (100μg/ml in Methanol)
CAS:Controlled ProductFormula:C14H10BrN3OColor and Shape:ColourlessMolecular weight:316.15Thiobutabarbital-d5
CAS:Controlled ProductFormula:C10H11D5N2O2SColor and Shape:NeatMolecular weight:233.34Nordazepam (1.0 mg/mL in Methanol)
CAS:Controlled ProductFormula:C15H11ClN2OColor and Shape:Single SolutionMolecular weight:270.71N-Methoxymethyl Phenobarbital
CAS:Controlled ProductApplications A Phenobarbital derivative. Anticonvulsant. References Hansch, C., et al.: J. Pharm. Sci., 61, 1 (1972), Andrews, P., et al.: J. Med. Chem., 26, 1223Formula:C14H16N2O4Color and Shape:NeatMolecular weight:276.288Clotiazepam-13C,d3
CAS:Controlled ProductApplications A labelled thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor.Controlled Substance. References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);Formula:C1513CH12D3ClN2OSColor and Shape:NeatMolecular weight:322.83
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