Hormones in Recombinant Proteins

Applications Gibberellin A4 is a plant growth hormone that regulates growth and differentiation of plant cells for elongation, germination and enzyme induction. References Zhang, R., et al.: Trees., 26, 1113 (2012); Sinska, I., et al.: Plant. Sci. Lett., 9, 163 (1977);

Applications A new labelled metabolite of 17α-Methyltestosterone (M326400). References Blokland, M., et al.: Anal. Chim. Acta, 529, 317 (2005), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Pozo, O.J., et al.: Drug Metab. Dispos., 37, 2153 (2009),

Applications Controlled substance (anabolic steroid). A prohormone of Trenbolone (T719000). References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),

AGRP Protein, Rhesus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.

Stability Hygroscopic Applications Active metabolite of Beclomethasone Dipropionate (BDP). References Soria, I., et al.: Biopharm. Drug Dispos., 19, 297 (1998), Harrison, L., et al., J. Pharm. Pharmacol., 51, 1235 (1999), Daley-Yates, P., et al.: Br. J. Clin. Pharm., 51, 400 (2001).

Applications A metabolite of Testosterone (T155000).CONTROLLED SUBSTANCE References Brandon, E., et al.: Toxicol. Appl. Pharmacol., 189, 233 (2003), Froehlich, A., et al.: Drug Metab. Dispos., 33, 1532 (2005), Schmelzer, E., et al.: Xenobiotica, 6, 693 (2006), Jasmund, I., et al.: Biomol. Eng., 24, 59 (2007),

Applications Prostanozol (P838700) derivative.

Applications A metabolite of Finasteride (F342000) in human bile (M2 metabolite). References Faller, B., et al.: Biochemistry, 32, 5705 (1993), Carlin, J.R., Drug Metab. Dispos., 25, 100 (1997), Bergman, E., et al.: Eur. J. Pharm. Sci., 29, 205 (2006),

Applications Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic. References Sadee, W., et al.: J. Pharm. Sci., 61, 1126 (1972), Peterfalvi, M., et al.: Biochem. Pharmacol., 29, 353 (1980), Los, L., et al.: Drug Metab. Dispos., 21, 1086 (1993), Ter Heine, R., et al.: J. Pharm. Biomed. Anal., 49, 451 (2009),

Applications Isotope labelled 17β-Estradiol (E888000), which is the major estrogen (1) secreted by the premenopausal ovary (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Salole, E. et al.: Anal. Profiles Drug Subs. 1986 15, 23 283-3182. Lievertz, R. et al.: Am. J. Obstet. Gynecol. 1987 May;156(5):1289-93.

Applications A labelled glucocorticoid microemulsion nasal preparation allergy inhibitor rhinitis. References ukuoka, E., et al.: Chem. Pharm. Bull., 35, 2943 (1987), Schmitt, E., et al.: J. Pharm. Sci., 88, 291 (1999), Hancock, B., et al.: Pharm. Res., 17, 397 (2000), Hogan, S., et al.: Pharm. Res., 18, 112 (2001).

AGRP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Applications Indole-2,4,5,6,7-d5-3-acetic Acid is an isotopic analog of Indoleacetic Acid (I577340) which is the most common and naturally occuring plant hormone in the auxin class of hormones. It effects cell elongation, cell division as well as plant growth and development.

Applications Quillaic Acid an unglycosylated saponin from the Quillaja saponaria bark is used as a topical antiinflammatory. References Arrau, S. et al.: J. Ethnopharm., 133, 164 (2011);

Applications Testosterone-16,16,17-d3 17-Phenylpropionate, is the labeled analogue of Testosterone 17-Phenylpropionate (T155150), a Testosterone ester being misused by athletes in an attempt to improve sports performance. It can also be used as a therapy in glucocorticoid-treated patients to increase the circulating testosterone concentration. References Shackleton, C. H. L., et al.: Steroids, 62 (7), 523 (1997); Reid, I. R., et al.: Archives Internal Med., 156 (11), 1173 (1996);

Stability Hygroscopic Applications A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. References Parmentier, G. , et al.: Steroids, 30, 583 (1977), Tserng, K.Y., et al.: Lipids, 13, 479 (1978),

Applications 1α-Methyl-5α-androstan-3α,17β-diol is an metabolite of anabolic androgenic steroid, testosterone (T155000). 1α-Methyl-5α-androstan-3α,17β-diol is also the methylated analogue of 5α-Androstane-3β,17β-diol (A637526). References Monetti, G., et al.: J. Steroid Biochem., 25, 765 (1986); Gragkaki, A.G., et al.: J. Steroid. Biochem. Molec. Biol., 115, 44 (2009); De Boer, D., et al.: J. Steroids. Biochem. Molec. Biol., 42, 411 (1992);

Applications A bile acid with hemolytic properties. Inhibits the initiation of Clostridium difficile spore germination. Anti-inflamatiory activity. References Segal, R. et al.; Life Sci. 10, 685 (1971); Sorg, J. et al.; J. Bacteriol. 192, 4983 (2010). Yasukawa, K. et al.; J. Pharm. Pharmacol. 61, 1051 (2009)

Adiponectin Protein, Mouse, Recombinant is expressed in E. coli. The accession number is Q60994.

Stability Light Sensitive, Temperature Sensitive Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),

Applications Labelled Pregnanetriol, a steroid present at elevated levels in the urine of patients with congenital adrenal hyperplasma. During treatment with cortisol replacement, elevated urine Pregnanetriol levels indicate insufficient dosage of cortisol. Pregnanetriol is also one of the urinary marker for adrenal incidentaloma. Pregnanetriol is a metabolite of Androstenedione (A637550). References Kinoshita, K. et al.: J. Clin. Endocrinol., 26, 1219 (1966); Kotlowska, A. et al.: Clin. Biochem., 42, 448 (2009); Wang, J. et al.: Zhipu Xue., 25, 201 (2004);

Applications 3-Iodothyronamine (4-Hydroxyphenyl-13C6) Hydrochloride is an isotopic analog of 3-Iodothyronamine Hydrochloride (I720500), a novel metabolite of thyroid hormone. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Davis, P., et al.: Thyroid, 6, 497 (1996); Falkenstein, E., et al.: Pharmacol. Rev., 52, 513 (2000); Yen, P., et al.: Physiol. Rev., 81, 1097 (2001); Pinna, G., et al.: Endocrinology, 143, 1789 (2002); Dhillo et al.; Diabetes, Obesity & Metabolism, 10, 167-70 (2008);