Hormones in Recombinant Proteins

Applications Preclinical profile of Ciclesonide, a novel corticosteroid for the treatment of asthma. This compound is a mixture of diastereomers at the cyclohexyl acetal. References Austin, R., et al.: Eur. Respir. J., 20, 1386 (2002), Belvisi, M.G., et al.: J. Pharmacol. Exp. Ther., 314, 568 (2005), Richter, K., et al.: J. Clin. Pharmacol., 45, 146 ( 2005).

Adiponectin Protein, Human, Recombinant is expressed in HEK293 Cells. The accession number is Q15848.

Applications Labelled Clobetasol. Topical corticosteroid. Glucocorticoid; anti-inflammatory. References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Applications Labelled Cyproterone Acetate. The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne. References Moltz, L., et al.: Contraception, 21, 393 (1980), Hammerstein, J., et al.: J. Steroid Biochem., 29, 591 (1983)

Applications A metabolite of Androsterone (A637535). References Goldzieher, J., et al.: J. Clin. Endocrinol. Metab., 29, 171 (1969), Parr, M., et al.: Steroids, 72, 545 (2007), Lippi, G., et al.: Clin. Biochem., 42, 904 (2009),

Stability Light Sensitive Applications 9-cis-Retinoic Acid Methyl Ester is a cis-Vitamin A derivative. References Englert, G., et al.: Helv. Chimica Acta, 58, 2367 (1975),

Applications Dexamethasone-d3 is the labelled form of Dexamethasone (D298800), which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T-cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Applications Bazedoxifene Acetate is a nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene Acetate is used as an antiosteoporotic. References van Hoorn, W., et al.: J. Med. Chem., 45, 584 (2002); Neubauer, B., et al.: Cancer Res., 63, 6056 (2003); Yan, X., et al.: Biochemistry, 43, 909 (2004);

AGRP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Applications (4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone-d4 is an intermediate in the synthesis of Ezetimibe-d4 (E975002). Ezetimibe-d4 is the labelled analog of Ezetimibe (E975000), an antihyperlipoproteinemic and a cholesterol absorption inhibitor. References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)

Applications A labelled glucocorticoid. References Hall, E.D., et al.: J. Neurosurg., 76, 13 (1992), Hommes, O.R., et al.: Mult. Scler., 1, 327 (1996), Bracken, M.B., et al.: J. Neurosurg., 89, 699 (1998), Dammers, J.W.H.H., et al.: Brit. Med. J., 319, 884 (1999)

Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis.

Applications Des(1-azepanyl)ethyl Bazedoxifene is a metabolite of Bazedoxifene (B129250), a nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene Acetate is used as an antiosteoporotic. References Rao, K. V., et. al.: J. Chromatogr. Sci., 51, 215 (2013)

Applications A derivatives of Dexamethasone (D298800), an analog of cortical hormones. References Giesen, E.M., et al.: Molec. Cell. Endocrinol., 22, 153 (1981),

Applications Deuterated Ursodeoxcholic Acid. Used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7. References Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986), Poupon, R.E, et al.: N. Engl. J. Med., 324, 1548 (1991), MacKenzie, P., et al.: J. Biol. Chem., 283, 36205 (2008),

Stability Hygroscopic Applications Androsterone (A637535) analogue. A precursors of Testosterone (T155000) and Nandrolone (N315000). References Franke, W., et al.: Clin. Chem., 43, 1262 (1997), Rivier, L., et al.: Chimia, 56, 84 (2002), Leinonen, A., et al.: Steroids, 69, 101 (2004),

Applications Dexamethasone Acid Ethyl Ester is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Applications A Dexamethasone Dipropionate metabolite. References Civiale, C., et al.: J. Ocul. Pharmacol. Thera., 20, 75 (2004),

Applications A labelled glucocorticoid microemulsion nasal preparation allergy inhibitor rhinitis.This compound is a mixture of diastereomers at the cyclohexyl acetal. References Fukuoka, E., et al.: Chem. Pharm. Bull., 35, 2943 (1987), Schmitt, E., et al.: J. Pharm. Sci., 88, 291 (1999), Hancock, B., et al.: Pharm. Res., 17, 397 (2000), Hogan, S., et al.: Pharm. Res., 18, 112 (2001).

Applications A corticosteroid prodrug for the treatment of eye disorders. References Benameur, H., et al.: J. Pharm. Pharmacol., 47, 812 (1995), Tauchi, Y., et al.: Biol. Pharm. Bull., 24, 925 (2001), Chono, S., et al.: J. Drug Targeting, 13, 407 (2005),

Adiponectin Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.

Applications 21-Butyryloxy Budesonide is a derivative of Budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide. References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979); Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980); Clissold, S.P., et al.: Drugs, 28, 485 (1984)

Impurity Rocuronium EP Impurity B Applications 3-Acetyl Rocuronium Bromide (Rocuronium EP Impurity B) is an impuritiy of Rocuronium bromide (R639500), an aminosteroid and a competitive neuromuscular blocker. References Srinivasan, N., et al.: Oriental. J. Chem., 24, 989 (2008); Magorian, T., et al.: Anesthesiology, 79, 913 (1993); Wicks, T.C., et al.: J. Am. Assoc. Nurse Anesth., 62, 33 (1994)

Applications 6-Ethylchenodeoxycholic-d5 Acid is an isotope labelled compound of 6-Ethylchenodeoxycholic Acid (E899810), which is used in the investigative treatment of primary biliary cholangitis. Primary biliary cholangitis is an autoimmune disease of the liver that slowly progresses to cirrhosis. References Ali, A. H, et al.: Expert Opin. Orphan Drugs, 4, 1011 (2016)

Applications Synthetic anabolic steroid related to testosterone.Controlled substance (anabolic steroid). References Campbell, J.A., et al.: Steroids, 1, 317 (1963); Hamlin, W.E., et al.: J. Pharm. Sci., 54, 1651 (1965); Sokolowski, J.H., et al.: J. Am. Vet. Med. Assoc., 173, 983 (1978),

Stability Very Hygroscopic Applications Mixed conjugate of dietary phytoestrogen. References Adlercreutz, H;., et al.: J. Steroid Mol. Biol., 52, 97 (1995), Kinjo, J., et al.: Biol. Pharm. Bull., 27, 185 (2004),

Applications Labelled Androgen. It has been used as an androgenic agent. Controlled substance (anabolic steroid). References Bichet, N., et al.: Toxicol. Appl. Pharmacol., 106, 509 (1990), Gustafson, D., et al.: Toxicol. Sci., 53, 245 (2000), Copple, B., et al.: Toxicol. Sci., 77, 172 (2004), Takashima, K., et al.: Life Sci., 78, 2787 (2006),

Stability Hygroscopic Applications Sodium Salt of Tauro-α-muricholic Acid-d4 is a labeled bile acid released by the liver and is typically used in cholestasis studies. References Yang, L. et al.: Chem. Res. Toxicol., 21, 2280 (2008); Holm, R. et al.: Phys. Chem. Chem. Phys., 11, 5070 (2009);

Applications 6α-Methyl-9α-fluoro-11β,17α-dihydroxyprogesterone is an impurity of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory. References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),

Applications Epitestosterone Sulfate is an metabolite of Epitestosterone (T155005), a steroid hormone that has been demonstrated to act at various levels as a weak antiandrogen. References Havlikova, H., et al.: J. Clin. Endocrinol. Metab., 87, 2225 (2002); Fernand Dray, et al.: Steroids., 10, 501 (1967) Bowers, L.D., et al.: J. Steroid, Biochem. Molec. Biol., 58, 225 (1996);

Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid.

Applications Deflazacort-d3, is the labeled analogue of Deflazacort (D228975), a systemic corticosteroid, and a derivative of prednisolone. Used for rheumatoid arthritis and lupus. References Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984), Imbimbo, B., et al.: Adv. Exp. Med. Biol., 171, 241 (1984),

Applications Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)

Applications Labelled Hyodeoxycholic Acid. Unlabelled version is isolated from pig bile. Antitumor agent. References Abadie, C., et al.: Biochem. J., 299, 725 (1994), Taniguchi, T., et al.: J. Biol. Chem., 269, 10071 (1994), Davis, R., et al.: J. Lipid Res., 43, 533 (2002),

Applications Labelled Isoflupredone (I816600). Anti-inflammatory. References Buchwald, P., et al.: Steroids, 73, 193 (2008), Holbeck, S., et al.: Mol. Endocrinol., 24, 1287 (2010),

Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland.

Applications 6α-Hydroxy-11-deoxycortisol is a corticosteroid which is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. References Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),

Stability Hygroscopic Applications 5β-Dihydrocortisol-d6 is an isotope labelled analog of 5β-Dihydrocortisol (D448595). 5β-Dihydrocortisol, is a derivative of Cortisol (H714615), which is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. References Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),

Stability Hygroscopic Applications A metabolite of Equilin (E592800). References Enmark, E., et al.: J. Clin. Endocrinol. Metab., 82, 4258 (1997), Wang, Z., et al.: J. Med. Chem., 43, 2419 (2000), Jiang, X., et al.: Steroids, 71, 334 (2006),

Applications Testosterone-16,16,17-d3 Hexanoate is a useful isotopically labeled compound of Testosterone Hexanoate (T155125)

Applications Campesteryl Ferulate is a component of γ-​oryzanol with antioxidant activities. References Xu, Z., et al.: J. Agric. Food Chem., 49, 2077 (2001);

Hepcidin Protein, Larimichthys crocea, Recombinant is expressed in E.

Stability Hygroscopic Applications A bacteriostatic antibiotic with similar activity and better absorption after oral administration (in animals) than the sodium salt of Fusidic Acid (F865500). Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. References Findon, G. et al.: Lab. Anim. Sci., 41, 462 (1991); Parsons, R.L. et al.: Curr. Chemother. Proc. Int. Cong. Chemother., 10, 384 (1978);

Applications An analog of Thyroxine (L425600) with stimulatory effects on human red blood cell membrane Ca2+-activated ATPase. It is a potential inactivator of iodothyronine deiodinase type II. References Davis, F.B. et al.: J. Biol. Chem., 258, 12373 (1983); Safran, M. et al.: J. Biol. Chem., 268, 14224 (1993);

Stability Hygroscopic Applications Parathyroid Hormone Fragment (1-34)-24,d3,TFA Salt is the labeled (on Leucine-d3, position 24) analogue of Parathyroid Hormone Fragment (1-34) (P192200), which is a fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors. References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);