Hormones in Recombinant Proteins

Stability Light Sensitive Applications 3-Chloro-3’,5,5’-triiodo-L-thyronine is a chlorinated derivative of 3,3’,5’-Triiodo-L-thyronine (T795350), used for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus. References Block, P.: J. Med. Chem., 19(8), 1067-1069 (1976); Shiba, T., & Cahmann, H.J.: J.O.C., 29, 1652-1653 (1964)

Applications Calusterone-d5 is the labeled analogue of Calusterone (C148900), a synthetic androgen epimeric with Bolasterone (B674970). Has been used in treatment of breast cancer. Controlled substance (anabolic steroid). References Horn, H., et al.: Br. J. Cancer, 33, 336 (1976); Zumoff, B., et al.: J. Clin. Endocrinol. Metab., 44(6), 1203 (1977)

Applications Labelled Δ4-Pregnen-20α-ol-3-one (P712215). Δ4-Pregnen-20α-ol-3-one is the main metabolite of Progesterone (P755900). Studies shows regulation of estrogen receptor levels in breast cancer by Δ4-Pregnen-20α-ol-3-one and other progesterone metabolites. References Zhang, L. et al.: Yaoz. Xueb., 39, 613 (2004); Pawlak, K.J. et al.: J. Steroid. Biochem. Mol. Biol., 107, 172 (2007);

Stability Acid Sensitive Applications 17β-(Trimethylsiloxy)testosterone is an anabolic steriod, and a derivative compound of Testosterone (T155000), Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Testerone is a controlled substance (anabolic steroid). Androgen. References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),

Applications Ipamorelin is a metabolite of growth hormone releasing peptides (GHRPs). Ipamorelin is a pentapeptide with strong growth hormone releasing potency that evokes insulin release from pancrease of normal and diabetic rats. References Semenistaya, E., et al.: Drug Testing and Anal., 7, 919 (2015); Adeghate, E., et al.: Neuroendocrinol. Lett., 25, 403 (2004)

Applications A metabolite of Mifepristone. References Heikinheimo, O., et al.: J. Steroid Biochem., 26, 279 (1987), Brogden, R., et al.: Drugs, 45, 384 (1993), Shi, Y., et al.: Contraception, 48, 133 (1993), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Gainer, E., et al.: Steroids, 68, 1005 (2003),

Applications A common enironmental pollutant showing weak estrogenic effects. Has been shown to cause harm to the male reproductive system of vertebrates in particular among aquatic species where gonadal intersex, altered sex ratios, and reduced gonad size has been observed. References Nishio, E., et al.: Biosci., Biotechnol., Biochem., 69, 1226 (2005), Barber, L., et al.: Aquatic Toxicol., 82, 36 (2007), Vajda, A., et al.: Environ. Sci. Technol., 42, 3407 (2008),

Applications Isotope labelled testosterone enanthate is a derivative of testosterone (T155000), the principal hormone of the testes, produced by the interstitial cells. References Janjic, M.M., et al.: Reproduct. Toxicol., 34, 686 (2012); Lacreuse, A., et al.: Physiol. Behaviour., 106, 229 (2012);

Stability Hygroscopic Applications Cabergoline is an ergot derivative and a dopamine D2-receptor agonist (1,2,3). It inhibits the secretion of prolactin and growth hormone. References (1) Kvernmo, T., et al.: Clin.Ther. 28 1065 (2006)(2) Boutinaud, M., et al.: J Dairy Sci. 99, 5707 (2016)(3) Hutton, J.T., et al.: Neurology, 46, 1062 (1996

Stability Hygroscopic Applications Dexamethasone 11,21-diacetate, is an impuriy of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);

Applications Anabolic steroid. Controlled substance. References Arriza, J., et al.: Science, 237, 268 (1987), Lill, M., et al.: J. Med. Chem., 47, 6174 (2004), Bledsoe, R., et al.: J. Biol. Chem., 280, 31283 (2005),

Stability Hygroscopic Applications A labelled glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal). References Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972), Bernstein, I.L., et al.: Chest, 81, 20 (1982),

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.

Stability Light Sensitive Applications An antineoplastic (hormonal). References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)

Applications A synthetic progesterone, used to induce oestrus synchronisation in goats and sheep. References Mei, C., et al.: Reproduct. Dom. An., 44, 735 (2009), Letelier, C., et al.: Theriogenol., 71 676 (2009), Letelier, C., et al.: Fertil. Steril., 93, 1308 (2010),

Applications Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986); Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989); Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988); Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)

Applications 2-Isobutyryl-N-phenyl-3-phenylacrylamide is the labeled analogue of 2-Isobutyryl-N-phenyl-3-phenylacrylamide (I781040), an intermediate for the synthesis of Atorvastatin-d5 Sodium Salt (A791753), the labeled analogue of Atorvastatin (A791750) (1,2,3). Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References (1) Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993) (2) Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996) (3) Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Stability Hygroscopic Applications A metabolite of Triamcinolone acetonide. References Edsbacker, S., et al.: Drug Metab. Dispos., 11, 590 (1983), Szefler, S., et al.: Eur. J. Clin. Pharmacol., 30, 323 (1986), Hansel, T., et al.: J. Immunol. Methods, 145, 105 (1991), Argenti, D., et al.: J. Clin. Pharmacol., 39, 695 (1999),

Applications Glycine 6-Ethylchenodeoxycholate-d5 is the labelled version of Glycine 6-Ethylchenodeoxycholate (G625250) which can be used as reactant/reagent in synthetic preparation of bile acid analogs as FXR/TGR5 agonists. References Or, Y., et al.: PCT Int. Appl., WO 2016073767 A1 20160512 (2016)

Applications Labelled Choleretic. References Mills, K.A., et al.: Pedatric Research, 43, 3 (1998)

Stability Hygroscopic Applications Cholenoic acid present in significant proportions during early gastation. References Setchell, K., et al.: J. Biol. Chem. 263, 16637 (1988), Nakagawa, M., et al.: J. Lipid Res., 31, 1089 (1990),

Applications A labelled metabolite of Equilin (E592800). References Enmark, E., et al.: J. Clin. Endocrinol. Metab., 82, 4258 (1997), Wang, Z., et al.: J. Med. Chem., 43, 2419 (2000), Jiang, X., et al.: Steroids, 71, 334 (2006),

Applications A degradation and metabolic intermediate of Dexamethasone (D298800). A Dexamethasone enol aldehyde as inflammation inhibitor. References Weiss, G., et al.: J. Clin. Endocrinol. Metab., 43, 696 (1976), Hirschmann R., et al.: Steroids, 57, 579 (1992),

Growth Hormone Protein, Human, Recombinant (CHO) is expressed in CHO Cells. The accession number is CAA23779.1.

FSH Beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.

Applications Methylstenbolone is an anabolic androgenic steroid that have been studied in respect of testosterone-receptor interaction and in the development of QSAR models. References Singh, D., et al.: J. Chem. Pharma. Rsch., 3, 1 (2011); McFarland, K., et al.: Science, 245, 494 (1989); Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000); Kumar, R., et al.: Biol. Reprod., 65, 710 (2001)

Applications It has been used in combinations as an oral contraceptive. References Brennan, D.M., et al.: Acta Endocrinol., 44, 367 (1963), Honma., s., et al.: Chem Pharm. Bull., 25 2019 (1977), Usui, T., et al.: Acta Urol. Jpn., 27, 327 (1981),

Stability Hygroscopic Applications A degradation product of Betamethasone (B327000). References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),

Applications It is used as cholesterol-lowering agent. References Bauer, D., et al.: Polym Deg. Stab., 48, 259 (1995), Nakahara, K., et al.: Chem. Physics Lett., 359, 351 (2002),

Applications A hydroxylated analogue of Tamoxifen (T006000) with anti-estrogenic properties. A Tamoxifen derivatives for imaging and treatment of estrogen receptor-positive tumors. References Ruenitz, P.C. et al.: J. Med. Chem., 25, 1056 (1982), Jalonen, H.G., et al.: J. Pharma. Sci., 77, 810 (1988), Yang, D.J., et al.: Pharma. Res., 8, 174 (1991),

Applications Isotope labelled Ethynyl Estradiol (E685100), an oral contraceptive (1), is a synthetic steroid with high oral estrogenic potency. Used in estrogen replacement therapy (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Koetsawang, S. et al.: Contraception. 1982 March:25(3) p231-2412. Cuttler, L. et al.: J. Endocrinol. Metab. 1985 Jun;60(6):1087-92.

Impurity Rocuronium EP Impurity E Stability Hygroscopic Applications 2-Pyrrolidinyl desmorpholinylrocuronium Bromide (Rocuronium EP Impurity E) is an impuritiy of Rocuronium bromide (R639500), an aminosteroid and a competitive neuromuscular blocker. References Srinivasan, N., et al.: Oriental. J. Chem., 24, 989 (2008); Magorian, T., et al.: Anesthesiology, 79, 913 (1993); Wicks, T.C., et al.: J. Am. Assoc. Nurse Anesth., 62, 33 (1994)

Applications Cholesteryl Decanoate-d3 is the labeled analogue of Cholesteryl Decanoate (C432535), a lubricant additive used to improve the performance of lubricants. References Pavlov, A.S., et. al.: Zavodskaya Laboratoriya, Diagnostika Materialov, 77, 55 (2011)

Applications A systematic corticosteroid. Anti-inflammatory. References Mroszczak, E.J. et al.: J. Pharmac. Sci., 67, 920 (1978); Moellmann, H. et al.: Int. J. Clin. Pharmacol. Therap., 34, 1 (1996);

Applications A metabolite of Etiocholanolone. References Eriksson, H., et al.: Eur. J. Biochem., 15, 132 (1970), Cook, D., et al.: Endocrinology, 93, 1019 (1973),

GH2 Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues._x000D_ GH2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.01 kDa and the accession number is P01242.

Applications Triamcinolone Acetonide-d6 is the labeled analogue of Triamcinolone Acetonide (T767165), a glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal). References Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972); Bernstein, I.L., et al.: Chest, 81, 20 (1982)

Applications An impurity of Dexamethasone (D298800), Desoxymethasone, Fluocortolone (F500500) and Diflucortolone. References Dekker, D., et al.: 5, 195 (1980),

Choriogonadotropin subunit beta is also known as CG-beta, Chorionic gonadotrophin chain beta.

Applications A labelled cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. References Brindle, J., et al.: Nat. Med., 12, 1439 (2002), Lindon, J., et al.: Biomarkers, 9, 1 (2004), Holmes, E., et al.: Cell, 134, 714 (2008),

Stability Hygroscopic Applications The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt. References Ho, R., et al.: J. Biol. Chem., 279, 7213 (2004), Pasanen, M., et al.: Eur. J. Clin. Pharmacol., 62, 409 (2006), He, Y., et al.: Drug Metab. Dispos., 36, 1453 (2008),

Applications A metabolite of Desoxymetasone (D296970). References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),

Stability Moisture Sensitive Applications Dexamethasone 21-Mesylate is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. References Kim, T.H., et al.: J. Nanosci. Nanotech., 13, 7325 (2013); Joshi, T., et al.: Brit. J. Pharmacol., 172, 1360 (2015);

Impurity Fluocinolone Acetonide EP Impurity D Stability Hygroscopic Applications Fluocinolone acetonide-21-aldehyde, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching. References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),

Applications Androstenedione (A637550) analog, an aromatase inhibitor. References Marsh, D.A., et al.: J. Med. Chem., 28, 788 (1985),

Applications A labelled metabolite of Cortisol. References Dossing, M., et al.: Eur. J. Clin. Pharmacol., 25, 215 ( 1983), Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994), Raucy, J., et al.: Drug Metab. Dispos., 31, 533 (2003), Pal, D., et al.: Life Sci., 78, 2131 (2006),

Applications Pregnenolone-d6 is the labeled analogue of Pregnenolone (P712200), a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A. References Bjondahl, K., et al.: Med. Biol., 54, 454 (1976); Geick, A., et al.: J. Biol. Chem., 276, 14581 (2001); Johnson, D., et al.: Toxicol. Sci., 66, 16 (2002); Abe, C., et al.: Lipids, 42, 637 (2007)

Impurity Fluticasone EP Impurity G Applications Fluticasone Dimer Impurity (Fluticasone EP Impurity G) is a dimeric impurity of Fluticasone Propionate (F599500). References Mistry, N. et al.: J. Pharmac. Biomed. Anal., 19, 511 (1999);

Chorionic Gonadotropin/CGA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.

Applications Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism. References Hechter, O., et al.: Arch. Biochem. Biophys., 25, 457 (1950), Colingsworth, D.R., et al.: J. Biol. Chem., 203, 807 (1953), Florey, K., et al.: Anal. Profiles Drug Subs., 12, 277 (1983),

Applications 17β-neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. It can also work as an inhibitor of hERG channel trafficking. References Zhao, Q., et al.:Fitoterapia, 82, 735 (2011); Wang, L., et al.: J. Pharmacol. Exper. Ther., 320, 525 (2007)

Applications 5β-Dihydro Progesterone-d8 is labelled which is labelled 5β-Dihydro Progesterone (D449280), a metabolite of the neuroactive steroid Progesterone (PROG) (P755900). References Wiebe, J., et al.: Cancer Res., 60, 936 (2000), Lacasa, D., et al.: J. Biol. Chem., 276, 11512 (2001), Johansson, I., et al.: Brain Res., 934, 125 (2002), Leonhardt, S., et al.: Steroids, 68, 761 (2003),

Applications Labelled Chenodiol (Chenodeoxycholic acid). A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),

Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4. References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),

Applications Pralmorelin is a growth hormone secretagogue that acts on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone release. References Howard, A. D., et al.: Science, 273, 974 (1996)

Applications A labelled progestogen with low androgenic potency. References Viinikka, L., et al.: Eur. J. Clin. Pharmacol., 15, 349 (1979), Bergink, E.W., et al.: J. Steroid Biochem., 14, 175 (1981)