Hormones in Recombinant Proteins

Insulin-1 Protein, Mouse, Recombinant (His & Myc) is expressed in Yeast.

Applications Taurocholic Acid-d8 Sodium Salt is the isotope labelled analog of Taurocholic Acid Sodium Salt; a bile acid with potential tumor-promoting and tumor-initiating activities in the glandular stomach mucosa of F344 rats. References Furihata, C., et al.: Jpn. J. Cancer Res., 78, 32 (1987)

Applications 21-Dehydro Betamethasone is an impurity of Betamethasone (B327000), a corticosteroid used as an anti-inflammatory agent. References Chen, B., et al.: Steroids, 74, 30 (2009); Li, M., et al.: J. Pharm. Sci., 98, 894 (2009); Xiong, Y., et al.: J. Pharm. Biomed. Anal., 49, 646 (2009);

Applications A labelled steroid hormone with weak androgenic activity. It is metabolized from Testosterone (T155000) in the liver and is used in doping analysis to detect testosterone misuse. Controlled Substance. References Park, J., et al.: J. Anal. Toxicol., 14, 66 (1990),; Palonek, E., et al.: J. Steroid Mol. Biol., 55, 121 (1995); Aguilera, R., et al.: Clin. Chem. 47, 292 (2001); Flenker, U., et al.: Steroids, 73, 408 (2008); Saudan, C. et al.: Steroids, 70, 179 (2005);

Applications An injectable gonadotropin-releasing hormone (GnRH) super-agonist (also known as an LHRH agonist). Used in treatment of precocious puberty and commonly used in veterinary medicine to induce ovulation in mares. References Linde, R. et al.: Engl. J. Med., 305, 663 (1981); Manasco, P.K. et al.: J. Pediatr., 115, 105 (1989); Johnson, C.A. et al.: J. Anim. Sci., 81, 1300 (2003); Farquhar, V.J. et al.: J. Am. Vet. Med. Assoc., 218, 749 (2001);

Applications A labelled progesterone receptor antagonist with partial agonist activity. Abortifacient. References Healy, D.L., et al.: J. Clin. Endocrinol. Metab., 57, 863 (1983), Rauch, M., et al.: Eur. J. Biochem., 148, 213 (1985), Baulieu, E.E., et al.: Science, 245, 1351 (1989), Brogden, R.N., et al.: Drugs, 45, 384 (1993)

Prolactin Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.

Procalcitonin/CALCA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.

Applications Diflucortolone-d3 (D445617) derivative. A glucocorticoid.

Applications Controlled substance (anabolic steroid). Labelled prohormone of Trenbolone (T719000). References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),

Adiponectin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag.

Applications A metabolite of Triamcinolone acetonide. References Edsbacker, S., et al.: Drug Metab. Dispos., 11, 590 (1983), Szefler, S., et al.: Eur. J. Clin. Pharmacol., 30, 323 (1986), Hansel, T., et al.: J. Immunol. Methods, 145, 105 (1991), Argenti, D., et al.: J. Clin. Pharmacol., 39, 695 (1999),

Applications A common enironmental pollutant showing weak estrogenic effects. Has been shown to cause harm to the male reproductive system of vertebrates in particular among aquatic species where gonadal intersex, altered sex ratios, and reduced gonad size has been observed. References Nishio, E., et al.: Biosci., Biotechnol., Biochem., 69, 1226 (2005), Barber, L., et al.: Aquatic Toxicol., 82, 36 (2007), Vajda, A., et al.: Environ. Sci. Technol., 42, 3407 (2008),

Impurity Betamethasone EP Impurity C Applications (16β)-17,21-Dihydroxy-16β-methyl-pregna-1,4,9(11)-triene-3,20-dione (Betamethasone EP Impurity C) is used in biological studies to perform preclinical characterization of VBP15, a novel anti-inflammatory delta 9,11 steroid. This compound is also used in analytical studies to determine the stability from reversed-phase high performance liquid chromatography (RP-HPLC) to separate low levels of dexamethasone and other related compounds from betametasone, which is an active pharmaceutical ingredient. References Reeves, E.K.M., et al.: Bioorg., Med. Chem., 21, 2241 (2013), Xiong, Y., et al.: J. Pharm. Biomed. Anal., 49, 646 (2009)

Applications Labelled 17α-Hydroxyprogesterone (H952330). 17α-Hydroxy Progesterone is a metabolite of Progesterone. It was isolated from adrenal glands. References Pfiffner, N., et al.: J. Biol. Chem., 132, 459 (1940), Florey, K., et al.: Anal. Profiles Drug Subs.,4, 209 (1975),

Applications Chlormadinol Acetate-d3, is the labeled analogue of Chlormadinol Acetate (C343460), the active metabolite of Chlormadinone acetate (CMA) (C343500). References Vaitukaitis, J., et al.: J. Clin. Endocrinol. Metab., 33, 988 (1971), Handy, R., et al.: Drug Metab. Disposition., 2, 214 (1974), Fiet, J., et al.: Steroids, 66, 609 (2001),

Applications Quinbolone is an anabolic steroid. Quinbolone is a cyclopentenyl ether derivative of Boldenone (B675100) which is also its active metabolite. Quinbolone shows weak androgenic activity. References Balestreri, R. et al.: Arch. Maragl. Patol. Clin., 22, 369 (1966); Galletti, F. et al.: Steroids, 18, 39 (1971);

Applications Labelled Medroxyprogesterone, an orally active progestogen used in hormone replacement therepy (HRT), in the past has been used as a component of oral contraceptives. References Pan, Q., et al.: Mol. Hum. Reprod., 13, 797 (2007), Matsson, P., et al.: J. Pharmacol. Exp. Ther., 323, 19 (2007), Jukosky, J.A., et al.: Bull. Environ. Contam. Toxicol., 81, 230 (2008), Cherkasov, A., et al.: J. Med. Chem., 51, 2047 (2008),

Applications Testololactone, is the derivative of Testolactone (T154800), which is an antineoplastic agent that is a derivative of progesterone and is used to treat advanced stage breast cancer. References Dunkel, L.: Mol. Cell. Endocrinol., 254, 207 (2006); Eugster, E. A.: Treat. Endocrinol., 3, 141 (2004); Holbeck, S.L. et al.: Mol. Cancer Therap., 9, 1451 (2010);

Applications The minor metabolite of Deflazacort. References Bernareggi, A., et al.: J. Pharma. Biomed. Anal., 5, 177-81 (1987), Assandri, A., et al.: Xenobiotica, 13(3), 185 (1983), Martinelli, E., et al.: Drug Metab. Dispos., 7, 335 (1979),

Applications Exemestane-13C,D3 is the labeled analogue of Exemestane (E957000), an antineoplastic (hormonal). References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)

Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of

Impurity Raloxifene EP Impurity D Applications LY 88074 is a selective estrogen receptor modulator (SERM). LY 88074 has potential use in the treatment of estrogen deprivation syndrome. References Dai, S.Y. et al.: Proc. Nat. Acad. Sci. USA, 105, 7171 (2008); Dai, S.Y. et al.: Biochemistry, 48, 9668 (2009);

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells.