Hormones in Recombinant Proteins

Applications Vasopressin Acetic Acid Salt is an acidic salt of Vasopressin (V991530), an antidiurectic hormone. References Tokushige, S., et al.: Internal Medicine, 55, 1199 (2016)

Stability Hygroscopic Applications 3-Sulfoglycolithocholic Acid Disodium Salt is a derivative of Lithocholic acid (L469180). Lithocholic acid (LCA) is a putative tumor promoter,that is shown to be able to inhibit mammalian DNA polymerase β. References Ogawa, A., et al.: Jap. J. Canc. Res., 89, 1154 (1998)

Stability Hygroscopic Applications A metabolite of Digoxin (Dx) (D446575). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Fujii, Y., et al.: Clin. Chem., 37, 476 (1991), Salphati, L., et al.: Xenobiotica, 29, 171 (1999), Song, S., et al.: Drug Metab. Dispos., 27, 689 (1999),

Applications Isotope labelled 24-Hydroxycholesterol is the main cholesterol elimination product of the brain and was found to be increased in serum of Alzheimer patients. References Kolsch, H., et al.: J. Neural. Transm., 108, 475 (2001); Gamba, P., et al.: Aging. Cell., 10, 403 (2011); Seet, R.C.S., et al.: Free. Rad. Biol. Med., 48, 560 (2010);

Applications Labelled Trenbolone (T719000). Controlled substance (anabolic steroid). References Schanzer, W., et al.: Clin. Chem., 42, 1001 (1996), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008), Fragkaki, A., et al.: Steroids, 74, 172 (2009),

Applications Labelled Cholesterol (C432501). Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones. References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),

Applications Estrogen; antineoplastic (hormonal). References Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 11, 347 (1982),

Applications Deuterated Raloxifene, a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic. References Jone, C.D., et al.: J. Med. Chem., 27, 1057 (1984), Buelke-Sam, J., et al.: Reprod. Toxicol., 12, 217 (1998),

Applications Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer. References Tomasz, M.B., et al.: New Engl, J. Med., 424, 371 (2014);

Applications 3-O-tert-Butyldimethylsilyl-24-methyl-24-phenylsulfonyl-cholest-5-ene-3-ol-d7 is an intermediate in the preparation of labelled Campesterol (C155364).

Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),

Prolactin Protein, Human, Recombinant is expressed in E. coli. The accession number is P01236.

Applications Furazabol is an anabolic steroid with hypocholesterolemic properties. This is a controlled substance (anabolic steroid). References Shimoi, K., et al.: Methods Enzymol, 400, 263 (2005), Hintikka, L., et al.: Steroids, 73, 257 (2008), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008),

Applications Labelled Aldosterone antagonist. Diuretic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Sadee, W., et al.: J. Pharmacol. Exp. Ther., 185, 686 (1973), Pitt, B., et al.: Circulation, 108, 1831 (2003), Silvestre, J., et al.: J. Biol. Chem., 273, 4883 (1998), Struthers, A., et al.: Heart, 92, 1728 (2006),

Stability Hygroscopic Applications Butafosfan, a component of Catosal, is licensed for the treatment of metabolic disorders or as a tonic in swine. It reduces the stress-induced cortisol (C696302, d4 labelled) response after mixing of unfamiliar pigs. It can also increase milk production in Holstein cows in combination with cyanocobalamin. References De Groot, J., et al.: J. Vet. Pharmacol. Ther., 26, 222 (2003); Pereira, R., et al.: Animal, 7, 1143 (2013)

Applications Labelled Estradiol (E888000) derivative. An estrogen. References Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986), Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987),

Stability Hygroscopic Applications Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal). References Lam, P., et al.: Gynecol. Endocrinol., 24, 674 (2008), Chi, K., et al.: J. Urol., 180, 565 (2008), Menchaca, A., et al.: Theriogenol., 72, 477 (2009), Harada, T., et al.: Fertility and Sterility, 91, 675 (2009),

Applications 11-Oxo-betamethasone Dipropionate is an impurity of Betamethasone Dipropionate (B327005), a glucocorticoid used as an anti-inflammatory and antibacterial ointment for dermatosis. References Dahlman-Ghozlan, K., et al.: Exp. Dermatol., 13, 65 (2004), Gounni Abdelilah, S., et al.: Clin. Immunol., 120, 220 (2006), Hertl, M., et al.: J. Clin. Invest., 116, 1159 (2006),

Applications JHSB3 is an acyclic sesquiterpenoid that regulates many aspects of insect physiology. Juvenile Hormone regulate development, reproduction, diapause, and polyphenisms. References Kotaki, T., et al.: Org. Let., 11, 5234 (2009); Riddiford, L.: Adv. Insect Physiol., 24, 213 (1994); Wyatt, G., Davey, K.: Adv. Insect Physiol., 26, 1 (1996); Nijhout, H.: Insect Hormones (Princeton Univ. Press, Princeton) (1994)

Applications (E/Z)-4-Hydroxy Tamoxifen is selective estrogen receptor modulator. References Levenson, A., et al.: Cancer Lett., 125, 215 (1998), Zhao, C., et al.: J. Steroid Biochem. Mol. Biol., 98, 1 (2006), Bellavance, E., et al.: J. Med. Chem., 52, 7488 (2009),

Applications Labelled Loteprednol Etabonate, an ophthalmic corticosteroid. Used as an anti-inflammatory. References Alberth, M., et al.: J. Biopharm.Sci., 2, 115 (1991), Bodor, N., et al.: Pharm. Res., 9, 1275 (1992), Bartlett, J.D., et al.: J. Ocul. Pharmacol., 9, 157 (1993)

Applications A labelled metabolite of Estradiol (E888000). References Ball, P., et al.: Steroids, 33, 563 (1979), Wong, T., et al.: Clin. Chem., 38, 1830 (1992), Xu, X., et al.: J. Clin. Endocrinol. Metab., 84, 3914 (1999), Todorovic, R., et al.: Carcinogenesis, 22, 905 (2001), Travis, R., et al.: Breast Cancer Res., 5, 239 (2003),

Applications Mometasone-d5 is the Isotope labelled analogue of Mometasone (M489995), a potent topical corticosteroid. Mometasone has potent antiinflammatory activity and is used in the treatment of dermatological disorders. References Schulz, M. et al.: Pharm. Zeit., 139, 28 (1994); Prakash, A. et al.: Drugs, 55, 145 (1998);

Applications Androstenediol 3-Acetate is an intermediate in the synthesis of Pregnenolone (P712200) which is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. References Stastna, E., et al.: Steroids., 75, 721 (2010);

Applications The natural isomer of the abscission-accelerating plant hormone. References Krochko, J.E., et al.: Plant Physiol., 118, 849 (1998), Jacobsen, J.V., et al.: Psysiol. Plant., 115, 428 (2002),

Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);

Prolactin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.