Hormones in Recombinant Proteins

The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes

Applications Labelled Budesonide, a non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent. References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979), Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980), Clissold, S.P., et al.: Drugs, 28, 485 (1984),

Applications Possible Progesterone metabolite. References Meng, L., et al.: J. Hepatol., 27, 346 (1997), Ho, C., et al.: Biochem., 45, 5695 (2006),

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR).

Applications Isopregnanolone-d5 is the isotope labelled analogue of Isopregnanolone (I822200), an derivative used in the preparation of antimicrobial and anti-leukemic steroids. References Shingate, B. et al.: Chem. Biol. Int., 1, 198 (2011); Jegham, H. et al.: Steroids., 77, 1403 (2012);

Stability Air Sensitive Applications Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid. References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),

Applications Labelled Flumethasone (F455000). A glucocorticoid. An anti-inflammatory. References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009),

Applications Δ7-Avenasterol is an analog of Stigmasterol (S686750); a plant sterol that is used as a precursor in the synthesis of progesterone. References Han, P., et al.: Biotechnol. App. Biochem., 54, 105 (2009); Matsunaga, I., et al.: Anal. Biochem., 393, 222 (2009); Huang, C., et al.: Plant Physiol., 150, 1192 (2009)

Applications Intermediate in the synthesis of a cholesterol absorption inhibitor. References Kambara, T. et al.; J. Org. Chem. 64, 9282 (1999); Wu, G. et al.; J. Org. Chem. 62, 6412 (1997)

Applications A metabolite of Stanozolol. References Stein, W.H., et al.: Biochim. Biophys. Acta, 24, 640 (1957).

Applications 6β-Hydroxy-11-deoxycortisol is a corticosteroid which is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. References Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),

Applications Testosterone-2,2,4,6,6-d5 Acetate is a useful isotopically labeled compound of Testosterone 17-O-Acetate (T155025)

Applications Isotope labelled Norethindrone (N676000), a labelled progesterone in combination with acetate used as an oral contraceptive (1,2). It is reasonably anticipated to be a human carcinogen. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Shroff, A. et al.: Anal. Profiles Drug Subst. 1975 ; 4;268-2932. Singh, H. et al.: Am. J .Obstet. Gynecol. 1979 Oct 1;135(3):409-14

Applications 5α-Pregnane-3-one-20α-ol, is a steroid metabolome, that can be used for in studies of a possible tool for laboratory diagnosis of schizophrenia. It is also a metabolite of Progesterone (P755900) in adipose cells. References Bicikova, M., et al.: J. Steriod Biochem. Mol. Bio., 77, 133 (2013); Zhang, Y., et al.: Mol. Cell. Endocrinology, 298, 76 (2009);

Adiponectin Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag.

CGB7 (chorionic gonadotropin, beta polypeptide 7) belongs to the glycoprotein hormones subunit beta family.

Applications 5β-Finasteride is an azasteroid and 5β-isomeric impurity of Finasteride (F342000). References Cendrowska, I. et al.: J. Liq. Chrom. Rel. Technol., 22, 2259 (1999);

Applications Pregnenolone-d4, is the labeled analogue of the Pregnenolone (P712200), which is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. References Bjondahl, K., et al.: Med. Biol., 54, 454 (1976), Geick, A., et al.: J. Biol. Chem., 276, 14581 (2001), Johnson, D., et al.: Toxicol. Sci., 66, 16 (2002), Abe, C., et al.: Lipids, 42, 637 (2007),

Applications It is one of the main labelled metabolite of Stanozolol (S684500), an internal standard in doping analysis. References Chung, B., et al.: J. Anal. Toxicol., 14, 91 (1990), Schanzer, W., et al.: J. Steroid Biochem., 36, 153 (1990), Phillis, B., et al.: Eur. J. Pharmacol., 398, 263 (2000),

Applications 2,2-Bis(4-hydroxyphenyl)-1,1,1-trichloroethane is an active metabolite of Methoxychlor that acts via the estrogen receptor (ER) to stimulate estrogen response element (ERE)-mediated gene transcription in estrogen-sensitive tissues. 2,2-Bis(4-hydroxyphenyl)-1,1,1-trichloroethane is used in epoxy resins and other epoxide compositions as industrial materials and electric insulators. References Willard, S. et al.: Res. J. Med. Med. Sci., 4, 171 (2009); Brzozowski, Z.K. et al.: Polimery, 17, 419 (1972); Kielkiewicz, J. et al.: Konf. Kunstst. Masch.-Fahrzeugbau. Vortr., 3, 325 (1973);

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin that plays an important role in fat accumulation.

Applications (R,S)-Equol is a human urinary metabolite of the soy isoflavones Daidzein (D103500). References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),

Applications 5-Androstenediol is a steroid androgen metabolite of Testosterone (T155000), the principal hormone of the testes, produced by the interstitial cells. References Miller, M., et al.: Steroids., 78, 15 (2013); Baker, M.E., et al.: Steroids., 77, 1192 (2012); Ronis, M.J.J. et al.: Comp. Biochem. Physiol.-C: Pharmacol. Toxicol. Endocrinol., 121C, 221 (1998);

Applications Labelled Fluticasone 17β-Carboxylic Acid Propionate (F599495). An impurity formed in the synthesis of Fluticasone propionate (F599500). References Phillips, G., et al.: J. Med. Chem., 37, 3717 (1994),

Applications A labelled form of Fenoxycarb (F248870), a carbamate insect growth regulator by preventing immature insects from reaching maturity by mimicking juvenile hormone. Used as a standard for Pesticide detection. Fenoxycarb is also used in cannabis testing kits as a component of pesticide mixes (P698235). References El-Saeid, M.H., et al.: J. Chem., 10, (2013); Coors, A., et al.: Environ. Toxicol. Chem., 31, 1239 (2012);

Meteorin-like/METRNL Protein, Mouse, Recombinant (His) is expressed in E.