Hormones in Recombinant Proteins

Applications An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. It is a peptidic V1a receptor agonist that produces vasoconstriction via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension. References Perucca, J. et al.: J. AM. Soc. Nephrol., 19, 1721 (2008); Toba, K. et al.: Prog. Brain Res., 119, 337 (1998); Berrada, K. et al.: J. Biol. Chem., 275, 27229 (2000);

Applications 6β-Hydroxy Betamethasone can be used as analyte in analytical study for detecting betamethasone metabolites in human urine using liquid chromatography coupled to tandem mass spectrometry. References Matabosch, X., et al.: Drug Testing and Analysis, 7, 663-672 (2015)

Stability Hygroscopic Applications Tixocortol is an anti-inflammatory agent. Tixocortol is used in fluorescent chemoaffinity labeling. References Torossian, D.R., et al.: Arzneim.-Forsch., 31, 453 (1981),

Applications Labelled Campesterol (C155360). A phytosterol, which may inhibit the intestinal absorption of cholesterol. References Fransen, H., et al.: J. Nut., 140, 1062 (2010), Kojoma, M., et al.: Plant Biotechnol., 27, 59 (2010), Orozco-Solano, M., et al.: J. Agric. Food Chem., 58, 7539 (2010),

Adiponectin Protein, Feline, Recombinant is expressed in E.

Applications Methyl Indole-2,4,5,6,7-d5-3-acetate is an isotopic analog of Methyl Indole-3-acetate (M313475), an important phytohormone. References Quittenden, L., et al.: Plant Physiol., 151, 1130 (2009), Jiraskova, D., et al.: J. Phycol., 45, 108 (2009),

Applications The major metabolite of Deflazacort. References Bernareggi, A., et al.: J. Pharma. Biomed. Anal., 5, 177-81 (1987), Assandri, A., et al.: Xenobiotica, 13(3), 185 (1983), Martinelli, E., et al.: Drug Metab. Dispos., 7, 335 (1979),

Applications A Labelled metabolite of Testosterone (T155000). It is a promising androgen for male hormonal contraception.CONTROLLED SUBSTANCE References Glass, A., et al.: J. Clin. Endocrinol. Metab., 45, 1211 (1977), Behre, H., et al.: Eur. J. Endocrinol., 140, 414 (1999), Nieschlag, E., et al.: Steroids, 68, 965 (2003), Wang, C., et al.: J. Clin. Endocrinol. Metab., 91, 460 (2006),

Impurity Mometasone Furoate Impurity N / Mometasone EP Impurity N Applications Icomethasone 21-Mesylate is a derivative of Icomethasone (I164100), used in the preparation of Mometasone (M489995).

Applications A common environmental pollutant showing weak estrogenic effects. Has been shown to cause harm to the male reproductive system of vertebrates. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Jiao, B., et al.: J. Cell. Biochem., 105, 1399 (2008), Hamelin, G., et al.: J. Toxicol. Environ. Health, Part A: Current Issues, 72, 541 (2009), Brian, J., et al.: Environ. Sci. Technol., 43, 214 (2009),

Stability Temperature Sensitive Applications 6-Defluro-6-oxo-fluticasone Propionate is a derivative of Flumethasone (F455000), a glucocorticoid, anti-inflammatory. References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009),

Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.

Applications (3β)-Allopregnanolone Sulfate is the sulfate conjugate of (3β)-Allopregnanolone, a metabolite of progesterone and a potent inhibitory modulator of GABAA receptors. References Li, P. et al.: Mol. Pharmacol., 77, 539 (2010); El-Etr, M. et al.: Brain Res., 790, 334 (1998); Park-Chung, M. et al.: Brain Res., 830, 72 (1999);

Applications Desoxymetasone-D5 is a labelled analogue of Desoxymetasone (D296970). Desoxymetasone is a fluorinated corticosteroid that is structurally related to Dexamethasone (D298800), and is used as a topical cream to treat eczema. References Heel, R., et al.: Drugs, 16, 302 (1978); Henry, M., et al.: Curr. Med. Res. Opin., 6, 502 (1980); Sehgal, Int. J. Derm., 15, 770 (1976)

Applications 6β-Hydroxy Dutasteride is a hydroxylated derivative of Dutasteride (D735000).

Stability Hygroscopic Applications 1,2-Dihydro Dexamethasone Phosphate Disodium Salt is an impurity of Dexamethasone Phosphate (D298835). References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),

Applications Diamethazine is an C17-alkylated, anabolic-androgenic steroid, that exhibits similar effects to Superdrol (M226010). References Orlandi, F., et al.: Adv. Hepatol. Trans. Int. Symp. Int. Assoc. Study Liver., 109 (1965); Shakoori, A. R, et al.: Proceeding. Congress. Zool., 24, 1 (2004);

Applications Toosendanin is a triterpenoid derivative and a novel agonist of L-type Ca2+ channels in neonatal rat ventricular cells (1,2,3). References (1) Li, M.F., et al.: Euro. J. Pharmacol., 501, 71 (2004) (2) Nakai, Y., et al.: Bioorg. Med. Chem., 18, 1280 (2010) (3) Zhang, B., et al.: Invest. New. Drugs., 23, 547 (2005)

Stability Hygroscopic Applications Synthetic peptide agonist analog of LH-RH. Triptoreline is a potent agonist of LH-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Antineoplastic (hormonal). Used in the treatment of endometriosis and infertility. References Sanders, L., et al.: Eur. J. Drug Metab. Pharmacokinet., 15, 95 (1990), Chiba, M., et al.: Biomaterials, 18, 893 (1997), Blanco, D., et al.: Eur. J. Pharm. Biopharm., 45, 285 (1998), Sinha, V., et al.: J. Control. Rel., 90, 261 (2003),

Applications Labelled analogue of 17-epi-Nandrolone, an epimer of the anabolic steroid Nandralone (N315000). Controlled substance (anabolic steroid). References Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990); Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991); Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007);

Applications Methyl Lithocholate is an derivative of Lithocholic Acid (L469180),a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. References Roleira, F.M., et al.: Lett. Drug. Design. Discovery., 7, 610 (2010);

Applications One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine. References Gross, J., et al.: Lancet I, 439 (1952), Roche, J., et al.: Biochim. Biophys. Acta, 11, 215 (1953), Chacon, M.A., et al.: J. Pediatr., 99, 758 (1981), Chopra, I.J., et al.: Thyroid, 6, 255 (1996),