Hormones in Recombinant Proteins

Applications A labelled metabolite in human hepatic bile. A lithocholic acid analog that inhibit sialyltransferase. References Ishikawa, H., et al.: J. Lipid. Res., 40, 1920 (1999), Gustafsson, U., et al.: Eur. J. Clin. Invest., 30, 1099 (2000), Gowda, G., et al.: Lipids, 41, 591 (2006), Lindon, J., et al.: Pharm. Res., 23, 1075 (2006),

Procalcitonin/CALCA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Applications 7β-Hydroxydehydroepiandrosterone (7β-OH DHEA) is the main metabolite of Dehydroepiandrosterone (DHEA) (D229585). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Smuga, D.A., et al.: Steroids, 75, 1146 (2010),

Impurity Fluocinolone Acetonide EP Impurity C Applications Fluocinolone, is a medication, used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin condition. It is also a derivative of Fluocinolone Acetonide (F455800). References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),

Applications Progesterone with antiestrogen and antiandrogen activity. References Brown-Grant, K., et al.: J. Endocrinol., 38, 145 (1967), Ferraresi, R., et al.: J. Allergy Clin. Immunol., 55, 25 (1975),

Applications 20α-Dihydrocortisol is a metabolite of Cortisol (H714615) which is a topical corticosteroid (1), more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland (2). Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis (3); suppress the immune system; and aid in fat, protein and carbohydrate metabolism. References Clark, D. et al.: Steroids 7, 352 (2006)

Applications Dibutyl Phosphate-d18 is the isotope labelled analog of Dibutyl Phosphate (D429520); a compound used in studies for novel cell-based reporter assay systems using epitope-tagged proteins for the identification of agonistic ligands of constitutive androstane receptors which are useful in many liver functions including xenobiotic and energy metabolism. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Imai, J., et al.: Drug Metabol., Pharmacok., 28, 290 (2013)

Applications 8R-Brassicasterol is a by-product in the synthesis of Brassicasterol (B676850). Brassicasterol is a phytosterol found in canola oil, rapeseed oil, marine algae and shellfish. This compound has been shown to inhibit sterol Δ24-reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway. References Bishop, G.J., et al.: Plant Cell Physiol. 42, 114, (2001); Fernandez, C., et al., Biochem. J. 366, 109 (2002)

Impurity Progesterone EP Impurity C Applications 20β-Dihydroprogesterone (Progesterone EP Impurity C) is an impurity of Progesterone (P755900), a steroid hormone secreted by the corpus luteum. Progesterone have various significant physiological roles, such as inducing the maturation and secretory activities of the uterine endothelium and the suppression of ovulation. Progesterone is also implicated in the etiology of breast cancer. References Anderson, E., et al.: Breast Cancer Res., 4, 197 (2002), Lanari, C., et al.: Breast Cancer Res., 4, 240 (2002), Albrecht, E.D., et al.: Front. Biosci., 8, 416 (2003), Qiu, M., et al.: J. Steroid Biochem. Mol. Biol., 85, 147 (2003),

Applications A 4-substituted Testosterone (T155000) analog. An anabolic steroid. References Maravelias, C., et al.: Toxicol. Lett., 158, 167 (2005), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1209 (2007), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008),

Applications A labelled metabolite of Norgestimate. References Phillips, A., et al.: Steroids, 55, 373 (1990)

Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)

Applications N-Acetyl-cys(1)-calcitonin Salmon is a derivative of Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). References Boron, WF., et al.: Med. Physi., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Applications 3-Iodothyronamine is a novel metabolite of thyroid hormone (TH). 3-Iodothyronamine (T1AM) is an endogenous and rapid-acting derivative of thyroid hormone. It has alos been found to increase food intake in rodents. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Davis, P., et al.: Thyroid, 6, 497 (1996), Falkenstein, E., et al.: Pharmacol. Rev., 52, 513 (2000), Yen, P., et al.: Physiol. Rev., 81, 1097 (2001), Pinna, G., et al.: Endocrinology, 143, 1789 (2002), Dhillo et al.; Diabetes, Obesity & Metabolism (2008), 10(2), 167-70

Applications A new metabolite of 17α-Methyltestosterone (M326400). References Blokland, M., et al.: Anal. Chim. Acta, 529, 317 (2005), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Pozo, O.J., et al.: Drug Metab. Dispos., 37, 2153 (2009),

Applications A synthetic corticosteroid derived from fluticasone for treatment of seasonal allergic rhinitis. References DeWester, J., et al.: Allergy Asthma Proc., 24, 331 (2003), Hughes, S., et al.: Drug Metab. Dispos., 36, 2337 (2008), Meltzer, E., et al.: Clin. Drug Investig., 29, 79 (2009),

Applications Trestolone acetate is a derivative of Trestolone (T719600), a synthetic androgen used as a potential hormonal male contraceptive method that induces a state of temporary infertility. References Garcia-Becerra, R., et al.: Reproduction., 143, 211 (2012); Attardi, B.J., et al.: J. Steroid. Biochem. Molec. Biol., 122, 212 (2010)

Applications Testosterone-2,2,4,6,6-d5 Propionate is a useful isotopically labeled compound of Testosterone Propionate (T155045)

Impurity Beclomethasone Dipropionate EP Impurity D Applications 9-Deschloro-9-bromo Beclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity D) is an impurity of Beclomethasone Dipropionate (B131030). References Shou, M. et al.: J. Pharmac. Biomed. Anal., 50, 356 (2009); Johnston, S. et al.: J. Chrom. Sci., 48, 733 (2010);

Applications An isotope labelled derivative of Methylmalonic Acid (M318860), binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status. References Pedersen, T., et al.: J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 879, 1502 (2011),

Applications A metabolite of Melatonin (M215000). References Mailliet, F., et al.: Biochem. Pharmacol., 71, 74 (2005), Leon, J., et al.: J. Neurochem., 98, 2023 (2006), Ma, X., et al.: Endocrinol., 149, 1869 (2008),

Impurity Rocuronium EP Impurity C Applications 17-Desacetyl Rocuronium Bromide (Rocuronium EP Impurity C) is a metabolite of Rocuronium (R639500), in human plasma. References Kleef, U., et al.: J. Chromatogr., 621, 65 (1993), Proost, J., et al.: Br. J. Anaesth., 85, 717 (2000),

Stability Hygroscopic Applications Taurochenodeoxycholic Acid-d5 (Major) Sodium Salt is the labelled analogue of Taurochenodeoxycholic Acid (T008130), a bile acid conjugate and metabolite Taurolithocholic Acid (T009100) with antiinflammatory activity. Taurochenodeoxycholic Acid has been shown to inhibit hepatocyte apoptosis through suppression of Bid translocation to mitochondria. References Emerman, S. et al.: J. Biol. Chem., 242, 661 (1967); Takikawa, Y. et al.: Falk Symp., 120, 249 (2001); Li, P. et al.: Zhong. Shour. Xue., 28, 1317 (2008)

Applications Estrogen; antineoplastic (hormonal). References Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 11, 347 (1982),

Applications (3α)-Pregnanolone Sulfate is the sulfate conjugate of (3α)-Pregnanolone (P711300). Pregnanolone Sulfate is an endogenous neurosteroid that inhibits NMDA receptors and is neuroprotective in vivo. References Kussius, C.L. et al.: J. Neurosci., 29, 6819 (2009); Elfverson, M. et al.: Neurppharmacology, 61, 1172 (2011); Johansson, T. et al.: Biochem. Biophys. Res. Comm., 401, 504 (2010);

Applications One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia. References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976), Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988), Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996), Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997),