Hormones in Recombinant Proteins

Applications Preclinical profile of Ciclesonide, a novel corticosteroid for the treatment of asthma. This compound is a mixture of diastereomers at the cyclohexyl acetal. References Austin, R., et al.: Eur. Respir. J., 20, 1386 (2002), Belvisi, M.G., et al.: J. Pharmacol. Exp. Ther., 314, 568 (2005), Richter, K., et al.: J. Clin. Pharmacol., 45, 146 ( 2005).

Adiponectin Protein, Human, Recombinant is expressed in HEK293 Cells. The accession number is Q15848.

Applications Labelled Clobetasol. Topical corticosteroid. Glucocorticoid; anti-inflammatory. References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Applications Labelled Cyproterone Acetate. The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne. References Moltz, L., et al.: Contraception, 21, 393 (1980), Hammerstein, J., et al.: J. Steroid Biochem., 29, 591 (1983)

Applications A metabolite of Androsterone (A637535). References Goldzieher, J., et al.: J. Clin. Endocrinol. Metab., 29, 171 (1969), Parr, M., et al.: Steroids, 72, 545 (2007), Lippi, G., et al.: Clin. Biochem., 42, 904 (2009),

Stability Light Sensitive Applications 9-cis-Retinoic Acid Methyl Ester is a cis-Vitamin A derivative. References Englert, G., et al.: Helv. Chimica Acta, 58, 2367 (1975),

Applications Dexamethasone-d3 is the labelled form of Dexamethasone (D298800), which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T-cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Applications Bazedoxifene Acetate is a nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene Acetate is used as an antiosteoporotic. References van Hoorn, W., et al.: J. Med. Chem., 45, 584 (2002); Neubauer, B., et al.: Cancer Res., 63, 6056 (2003); Yan, X., et al.: Biochemistry, 43, 909 (2004);

AGRP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Applications (4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone-d4 is an intermediate in the synthesis of Ezetimibe-d4 (E975002). Ezetimibe-d4 is the labelled analog of Ezetimibe (E975000), an antihyperlipoproteinemic and a cholesterol absorption inhibitor. References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)

Applications A labelled glucocorticoid. References Hall, E.D., et al.: J. Neurosurg., 76, 13 (1992), Hommes, O.R., et al.: Mult. Scler., 1, 327 (1996), Bracken, M.B., et al.: J. Neurosurg., 89, 699 (1998), Dammers, J.W.H.H., et al.: Brit. Med. J., 319, 884 (1999)

Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis.

Applications Des(1-azepanyl)ethyl Bazedoxifene is a metabolite of Bazedoxifene (B129250), a nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene Acetate is used as an antiosteoporotic. References Rao, K. V., et. al.: J. Chromatogr. Sci., 51, 215 (2013)

Applications A derivatives of Dexamethasone (D298800), an analog of cortical hormones. References Giesen, E.M., et al.: Molec. Cell. Endocrinol., 22, 153 (1981),

Applications Deuterated Ursodeoxcholic Acid. Used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7. References Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986), Poupon, R.E, et al.: N. Engl. J. Med., 324, 1548 (1991), MacKenzie, P., et al.: J. Biol. Chem., 283, 36205 (2008),

Stability Hygroscopic Applications Androsterone (A637535) analogue. A precursors of Testosterone (T155000) and Nandrolone (N315000). References Franke, W., et al.: Clin. Chem., 43, 1262 (1997), Rivier, L., et al.: Chimia, 56, 84 (2002), Leinonen, A., et al.: Steroids, 69, 101 (2004),

Applications Dexamethasone Acid Ethyl Ester is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Applications A Dexamethasone Dipropionate metabolite. References Civiale, C., et al.: J. Ocul. Pharmacol. Thera., 20, 75 (2004),

Applications A labelled glucocorticoid microemulsion nasal preparation allergy inhibitor rhinitis.This compound is a mixture of diastereomers at the cyclohexyl acetal. References Fukuoka, E., et al.: Chem. Pharm. Bull., 35, 2943 (1987), Schmitt, E., et al.: J. Pharm. Sci., 88, 291 (1999), Hancock, B., et al.: Pharm. Res., 17, 397 (2000), Hogan, S., et al.: Pharm. Res., 18, 112 (2001).

Applications A corticosteroid prodrug for the treatment of eye disorders. References Benameur, H., et al.: J. Pharm. Pharmacol., 47, 812 (1995), Tauchi, Y., et al.: Biol. Pharm. Bull., 24, 925 (2001), Chono, S., et al.: J. Drug Targeting, 13, 407 (2005),

Adiponectin Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.

Applications 21-Butyryloxy Budesonide is a derivative of Budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide. References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979); Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980); Clissold, S.P., et al.: Drugs, 28, 485 (1984)