Hormones in Recombinant Proteins

Applications 7α-Hydroxytestosterone, is a metabolite of Testosterone (T155000), a principal hormone of the testes, produced by the interstitial cells. References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001);

Applications A metabolite of Indole-3-acetic acid in plants. References Barratt, N., et al.: Physiol. Plant, 105, 207 (1999), Jackson, R., et al.: J. Biol. Chem., 276, 4350 (2001), Staswick, P., et al.: Plant Cell, 17, 616 (2005),

Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),

Impurity Beclometasone Dipropionate EP Impurity C Applications An impurity of Beclomethasone Dipropionate (B131030).

Glucagon is a secreted protein and belongs to the glucagon family.

Stability Hygroscopic Applications n-Heptyl 4-hydroxybenzoate-d4 is labelled n-Heptyl 4-hydroxybenzoate which is used to prepare sulfonylbenzoic acid esters as potential inhibitors of oestrone sulphatase with antitumor activities. References Owen, C., et al.: J. Pharm. Pharmacol., 55, 85 (2002)

Adiponectin Protein, Mouse, Recombinant (V113M) is expressed in E. coli. The accession number is Q60994.

Stability Light Sensitive Applications It is a fluorescent derivative of Cyclopamine that retains potency in Shh signaling inhibition (IC50=150nM). References Chen, K.J., et al.: Genes Develop., 16, 2743 (2002)

Impurity Mometasone Furoate EP Impurity C Applications (16α)-21-Chloro-17-[(2-furanylcarbonyl)oxy]-16-methyl-pregna-1,4-diene-3,11,20-trione (Mometasone EP Impurity C) is an impurity of Mometasone Furoate, a topical corticosteroid used as an anti-inflammatory. References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)

The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes

Applications Isotope labelled Testosterone Propionate (T155045), Anabolic steroid. Androgen.Controlled substance. References Glass, A., et al.: J. Clin. Endocrinol. Metab., 45, 1211 (1977), Behre, H., et al.: Eur. J. Endocrinol., 140, 414 (1999), Nieschlag, E., et al.: Steroids, 68, 965 (2003), Wang, C., et al.: J. Clin. Endocrinol. Metab., 91, 460 (2006),

Stability Very Hygroscopic Applications Labelled Glycochenodeoxycholic Acid (G641255). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. References Ollila, F., et al.: Langmuir, 17, 7107 (2001), Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004), Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005),

Impurity Beclomethasone Dipropionate EP Impurity L Applications 1,2-Dihydro Beclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity L) is an impurity of Beclomethasone Dipropionate (B131030).

Applications Thyroid hormone analog. Antilipemic. References Tomita, L., et al.: J. Biol. Chem., 219, 595 (1956)