Hormones in Recombinant Proteins

Applications 20α-Dihydrocortisol is a metabolite of Cortisol (H714615) which is a topical corticosteroid (1), more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland (2). Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis (3); suppress the immune system; and aid in fat, protein and carbohydrate metabolism. References Clark, D. et al.: Steroids 7, 352 (2006)

Applications Dibutyl Phosphate-d18 is the isotope labelled analog of Dibutyl Phosphate (D429520); a compound used in studies for novel cell-based reporter assay systems using epitope-tagged proteins for the identification of agonistic ligands of constitutive androstane receptors which are useful in many liver functions including xenobiotic and energy metabolism. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Imai, J., et al.: Drug Metabol., Pharmacok., 28, 290 (2013)

Applications 8R-Brassicasterol is a by-product in the synthesis of Brassicasterol (B676850). Brassicasterol is a phytosterol found in canola oil, rapeseed oil, marine algae and shellfish. This compound has been shown to inhibit sterol Δ24-reductase, an enzyme involved in the mammalian cholesterol biosynthesis pathway. References Bishop, G.J., et al.: Plant Cell Physiol. 42, 114, (2001); Fernandez, C., et al., Biochem. J. 366, 109 (2002)

Impurity Progesterone EP Impurity C Applications 20β-Dihydroprogesterone (Progesterone EP Impurity C) is an impurity of Progesterone (P755900), a steroid hormone secreted by the corpus luteum. Progesterone have various significant physiological roles, such as inducing the maturation and secretory activities of the uterine endothelium and the suppression of ovulation. Progesterone is also implicated in the etiology of breast cancer. References Anderson, E., et al.: Breast Cancer Res., 4, 197 (2002), Lanari, C., et al.: Breast Cancer Res., 4, 240 (2002), Albrecht, E.D., et al.: Front. Biosci., 8, 416 (2003), Qiu, M., et al.: J. Steroid Biochem. Mol. Biol., 85, 147 (2003),

Applications A 4-substituted Testosterone (T155000) analog. An anabolic steroid. References Maravelias, C., et al.: Toxicol. Lett., 158, 167 (2005), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1209 (2007), Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008),

Applications A labelled metabolite of Norgestimate. References Phillips, A., et al.: Steroids, 55, 373 (1990)

Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)

Applications N-Acetyl-cys(1)-calcitonin Salmon is a derivative of Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). References Boron, WF., et al.: Med. Physi., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Applications 3-Iodothyronamine is a novel metabolite of thyroid hormone (TH). 3-Iodothyronamine (T1AM) is an endogenous and rapid-acting derivative of thyroid hormone. It has alos been found to increase food intake in rodents. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Davis, P., et al.: Thyroid, 6, 497 (1996), Falkenstein, E., et al.: Pharmacol. Rev., 52, 513 (2000), Yen, P., et al.: Physiol. Rev., 81, 1097 (2001), Pinna, G., et al.: Endocrinology, 143, 1789 (2002), Dhillo et al.; Diabetes, Obesity & Metabolism (2008), 10(2), 167-70