Hormones in Recombinant Proteins

Stability Hygroscopic Applications Sodium Salt of Tauro-α-muricholic Acid-d4 is a labeled bile acid released by the liver and is typically used in cholestasis studies. References Yang, L. et al.: Chem. Res. Toxicol., 21, 2280 (2008); Holm, R. et al.: Phys. Chem. Chem. Phys., 11, 5070 (2009);

Applications 6α-Methyl-9α-fluoro-11β,17α-dihydroxyprogesterone is an impurity of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory. References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),

Applications Epitestosterone Sulfate is an metabolite of Epitestosterone (T155005), a steroid hormone that has been demonstrated to act at various levels as a weak antiandrogen. References Havlikova, H., et al.: J. Clin. Endocrinol. Metab., 87, 2225 (2002); Fernand Dray, et al.: Steroids., 10, 501 (1967) Bowers, L.D., et al.: J. Steroid, Biochem. Molec. Biol., 58, 225 (1996);

Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid.

Applications Deflazacort-d3, is the labeled analogue of Deflazacort (D228975), a systemic corticosteroid, and a derivative of prednisolone. Used for rheumatoid arthritis and lupus. References Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984), Imbimbo, B., et al.: Adv. Exp. Med. Biol., 171, 241 (1984),

Applications Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)

Applications Labelled Hyodeoxycholic Acid. Unlabelled version is isolated from pig bile. Antitumor agent. References Abadie, C., et al.: Biochem. J., 299, 725 (1994), Taniguchi, T., et al.: J. Biol. Chem., 269, 10071 (1994), Davis, R., et al.: J. Lipid Res., 43, 533 (2002),

Applications Labelled Isoflupredone (I816600). Anti-inflammatory. References Buchwald, P., et al.: Steroids, 73, 193 (2008), Holbeck, S., et al.: Mol. Endocrinol., 24, 1287 (2010),

Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland.