Hormones in Recombinant Proteins

Applications A metabolite of Fulvestrant (F862500). References Rao, P., et al.: J. Steroid Biochem., 25, 417 (1986), Wakeling, A., et al.: J. Steroid Biochem. Mol. Biol., 43, 173 (1992), DeFriend, D., et al.: Cancer Res., 54, 408 (1994),

Applications 4-Androsten-17alpha-methyl-17beta-ol-3-one-1,2-d2 is a useful isotopically labeled compound of 17α-Methyl Testosterone (M326400)

Human Hepcidin peptide hormone product also know as LEAP-1 (liver-expressed antimicrobial peptide), where the disulfides are formed by random oxidation. Hepcidin is a peptide hormone that is synthesized in the liver and is an important regulator of iron homeostasis. Through binding to ferroportin Hepcidin prevents the exportation of iron thus reducing the amount of circulating iron. Furthermore through inflammatory cytokine induction Hepcidin leads to the internalization and degradation of ferroportin thus further reducing the amount of iron in circulation. This in turn make conditions unfavourable to invading pathogens. This demonstrates Hepcidin's ability as an anti-microbial peptide. This antimicrobial behaviour can be used in research into the elimination of pathogens but also in combatting diseases where iron dysregulation is prevalant.

Applications Labelled Ulipristal (U700800). Ulipristal is a selective progesterone receptor modulator. Ulipristal is used during pregnancy. References Gronemeijer, H., et al.: J. Steroid Biochem., 40, 271 (1991), Spitz, I., et al.: Contraception, 48, 403 (1993), Conneely, O., et al.: Steroids, 68, 771 (2003), Chwalisz, K., et al.: Endocr. Rev., 26, 423 (2005),

Impurity Beclomethasone Dipropionate EP Impurity F Applications 6α-Bromo Beclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity F) is an impurity of Beclomethasone Dipropionate (B131030).

Applications A synthetic derivative of Dehydroepiandrosterone. The reduced androgenicity of Fluasterone may obviate toxicities associated with the androgenicity of the parent compound. Antitumor agent. Used in clinical trials for prostate cancer prevention. References Bentley, P., et al.: Food Chem. Toxicol., 31, 857 (1993), Rao, K., et al.: Cancer Res., 59, 3084 (1999), Masuzaki, H., et al.: Science, 294, 2166 (2001), Osawa, E., et al.: Life Sci., 70, 2623 (2002),

Insulin Porcine is a two chain, glycosylated polypeptide chain containing 51 amino acids and having a molecular mass of 5777 Dalton.  The a and b chains are joined by two interchain disulfide bonds with the a chain containing an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Applications N-Desmethyl Ulipristal Acetate is the N-monodemethylated analogue and metabolite of the selective progesterone receptor modulator Ulipristal Acetate (U700810). N-Desmethyl Ulipristal Acetate contributes significantly to the antiprogestational activity of its parent compound. References Attardi, B.J. et al.: J. Steroid Biochem. Mol. Biol., 88, 277 (2004);