Natural and semi-synthetic antibiotics

Pactamycin, an antibiotic from Streptomyces pactum, serves as an antineoplastic and protein synthesis inhibitor.

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Cefoselis Sulfate is a widely used beta-lactam antibiotic.

Erythromycin and its derivatives; salts thereof

Impurity Amoxicillin EP Impurity B ; Amoxicillin USP Related Compound B Applications L-Amoxicillin (Amoxicillin EP Impurity B) is an isomer of Amoxicillin (A634235), a semi-synthetic antibiotic related to penicillin. References Brogden, R.N., et al.: Drugs, 18, 169 (1979), Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994),

Pleuromutilin (Drosophilin B) is an inhibitor of bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.

N-tert-butyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide (CAS 1215006-11, API impurity) is a synthetic compound from the drug development process. This impurity has been identified in the natural product and is not an active ingredient. It is found as a Metabolite in the pharmacopoeia and analytical methods. This substance is used for research and development of drugs, such as for standardizing HPLC.

Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.

4-Hydroxy azithromycin is an impurity of Azithromycin that is a metabolite of the drug. 4-Hydroxy azithromycin is a synthetic product, which has been synthesized for use as an analytical standard for HPLC and LC-MS/MS. It has also been used as a pharmacopoeia standard for testing antibiotic purity and quality. Metabolism studies have shown that 4-hydroxy azithromycin is not absorbed from the gastrointestinal tract, but is found in the urine and feces.

Tetracycline hydrochloride is a broad-spectrum antibiotic, blocking protein synthesis in bacteria and used in bone histomorphometry.

Tacrolimus is a macrolide antibiotic that binds to the calcineurin receptor and inhibits the production of cytokines. It is used to treat certain types of autoimmunity and hyperproliferation in patients with cancer, organ transplant recipients, and those who have undergone radiation therapy. The drug is available in two forms: tacrolimus (the natural form) and desmethyl tacrolimus (a metabolite). Desmethyl tacrolimus is produced by microbial transformation, which converts the natural form into a more water-soluble derivative. This conversion can be prevented by adding additives such as proton pump inhibitors or pde5 inhibitors. Symptoms of tacrolimus include hyperglycemia, hyperlipidemia, gastrointestinal disturbances, headache, fever, skin rash, diarrhea, and anemia. Tacrolimus has been shown to inhibit the activity of fk506-binding proteins in vitro and in vivo through competitive inhibition.

Erythromycin impurity K is a synthetic impurity of erythromycin, which is an antibiotic drug product. It is typically found in pharmaceutical products that are made from natural sources and is used as a research and development (R&D) standard for the pharmacopoeia. Erythromycin impurity K can be purified by HPLC or other means to create high purity standards for analytical purposes. The chemical name of this compound is 3-[[[3-(2-Amino-4-thiazolyl)-1,2,4-triazol-5-yl]amino]methyl]-1H-indole.

Tylosin (Tylosine) is a macrolide antibiotic obtained from cultures of Streptomyces fradiae.