Carbohydrates and glycoconjugates

Lacto-N-neotetraose-GEL is a glycosylation product that is used in the synthesis of complex carbohydrates. It is a methylated, fluorinated, and saccharide-modified oligosaccharide. This product can be custom synthesized in high purity with a CAS number and has a very low endotoxin level. Lacto-N-neotetraose-GEL has been shown to have many uses including as an adjuvant for vaccines and monoclonal antibody production. It has also been shown to suppress inflammation and increase the efficacy of cancer treatments.

Man-3-Xyl-Fuc N-Glycan is a custom synthesis of mannose that has been modified with fucose and glycosylated with a conjugated xylose. This complex carbohydrate can be used in the manufacturing of pharmaceuticals, as well as in research for the production of biofuels.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Hepta-O-acetyl-b-Lactosyl-N-Fmoc-L-threonine is a substance that can be used for the diagnosis of radiation exposure. It is a liquid that is injected into the body, where it accumulates in tissues such as bone marrow. The presence of Hepta-O-acetyl-b-Lactosyl-N-Fmoc-L-threonine in bone marrow cells can be detected using an imaging technique called balloon injury. This liquid also has synergistic effects with radiation and may be useful for the treatment of diseases such as thrombolysis.

Shortest chain oligosaccharide that can be classified as a maltodextrin. A component of liquid glucose (a commercial sweetener composed of glucose, maltose, maltotriose and maltotetrose).

Intermediate degradation product of lyso-GM3

Hexaacetylchitohexaose is a hexamer of N-acetylgucosamine subunits which are linked by β-(1,4)-glucosidic bonds. N-acetylgucosamine is the monomeric unit of the natural polymer chitin which is degraded by chitinases, in mammals, to form smaller fragments that can induce an immune response. Like chitin and some of its derivatives, hexaacetylchitohexaose is a substrate of lysozymes. Hexaacetylchitohexaose has been shown to significantly inhibit tumour growth in mice by the activation of innate and adaptive immune cells.

Applications D-Xylulose can be used through fermentation to produce ethanol. References Yuan, D. et al.: Biores. Tech., 102, 3246 (2011);

GT3 oligosaccharide (free acid) is a disaccharide (Galβ1,4Glc) with three sialic acid residues (NeuAc) linked α2,8/α2,8/α2,3 to the galactose residue (Ledeen, 2009). The GT3 ganglioside is the carbohydrate moiety in the GT3 ganglioside, which is implicated in type 1 diabetes. GT3 ganglioside is expressed on pancreatic cells and is the target antigen of anti-GM3-antibodies, which contribute to the autoimmune destruction of pancreatic beta cells (Misasi, 1997). GT3 ganglioside is also abundant in lung tissues and the nervous system.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Chitobiose is a dimer formed by beta-1,4-linked glucosamine units. It is also the repeated dimer of chitin, a polysaccharide.

3'-Sialyllactose-BSA binds to human serum albumin. It is used in the detection of tumour cells in blood samples, and has been shown to be sensitive for the detection of malignant cells in sera from patients with metastatic breast cancer. 3'-Sialyllactose-BSA can also be used as a probe for the identification of glycosphingolipids in animal tissues. The antibody's specificity for glycosphingolipids was demonstrated by its ability to bind selectively to glycosphingolipid-containing liposomes, but not lipid vesicles without glycosphingolipids.

4-Methoxyphenyl 4-O-{2-O-acetyl-4-O-[2,4-di-O-(3,4,6-tri-O-acetyl-2,3,5,6 -tetra-O-[(triisopropylsilyl)oxy]-2,5 -dideoxyglucan]-b-(D)-glucopyranosyl)-3,4di O-[benzyl]-a-(D)-mannopyranosyl}b-(D)-mannopyranoside is a high purity custom synthesis sugar. It can be fluorinated and glycosylated with methylation and modification. This compound is an oligosaccharide that can be used as a monosaccharide or complex carbohydrate.

CTPI-2 inhibits SLC25A1 (KD: 3.5 μM), glycolysis, PPARγ, GLUT4, has anti-tumor effects, and combats NASH and diet-induced obesity.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

2-Acetamido-3,4,6-tri-O-acetyl-b-D-galactopyranosyl bromide is an intermediate in the synthesis of 2,6-dideoxyglucose and has been used as a model for the glycosidic linkage to fluoroquinolones. The compound is a white solid that can be synthesized by reacting D-galactose with acetamidobenzene in the presence of sodium hydroxide and chloroacetone. The molecular weight of this compound is 703.1 g/mol. This product was developed through custom synthesis and modification. It is available at high purity.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Drug carrier for cancer therapy & imaging, biocompatible, soluble, biodegradable

Hyaluronic acid is a polysaccharide containing repeating disaccharide units of β-1,3-N-acetyl glucosamine and β-1, 4-glucuronic acid. A series of unsaturated oligosaccharides (oligouronic acids) are released from hyaluronic acid by the action of hyaluronidase on the umbilical cord (Weissman, 1954). This decasaccharide and other enzymatically produced polymer homologs have been of value in the study of hyaluronic acid metabolism in both healthy and diseased tissues (Hascall, 2019).

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Non-reducing storage and transport sugar in woody plants; used as a sweetener

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Applications Triamilide antibiotic for treatment of bovine and porcine respiratory disease. Exists as an equilibrium mixture of two isomeric forms, Tulathromycin A (90%) and B (10%). Antibacterial. References Benchaoui, H.A., et al.: J. Vet. Pharmacol. Ther., 27, 203 (2004), Nowakowski, M.A., et al.: Vet. Ther., 5, 60 (2004),

Galactose 1-phosphate, an intermediate substance in both galactose metabolism and nucleotide sugar processes, plays a crucial role in the biochemical pathways

Applications Cytidine 5’-Diphosphate Ethanolamine Disodium Salt is an analog of Cytidine 5’-Diphosphate with an important role in the metabolism of phospholipides. References Trotter, P., et al.: J. Biol. Chem., 270, 6062 (1995), Janssen, M., et al.: Yeast, 16, 641 (2000), Henneberry, A., et al.: Mol. Biol. Cell, 12, 511 (2001), Boumann, H., et al.: Biochemistry, 42, 3054 (2003),

1,3-a-1,6-a-D-Mannotriose 1-O-propylamine acetate salt is a modified oligosaccharide. It has been synthesized by the reaction of 1,3-a-1,6-a-D-mannopyranosyl bromide with proline amine acetate. This product is 98% pure and can be used as a complex carbohydrate in research or as a food additive. The CAS number for this product is 712092-14-8.

Key synthetic precursor for the synthesis of lacto-oligosaccharides

a1,4-Mannobiose-BSA is a complex carbohydrate that can be synthesized in the laboratory. It is composed of mannose and glucose units. This molecule has been modified with methyl groups, which can be used for click chemistry reactions. Mannobiose-BSA is a polysaccharide with CAS number 56938-64-2. It has been modified by Click chemistry and glycosylation to yield high purity compounds.

Lonicerin: antioxidant, anti-arthritic, antifungal; potential for combined fungal arthritis treatment from C. albicans.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Sialylated trisaccharide found in human urine

Anti-CD200RLa Antibody (5K764) is a Mouse antibody targeting CD200RLa. Anti-CD200RLa Antibody (5K764) can be used in ELISA,ELISA(Det).

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Neutral pentasaccharide naturally present in human breast milk

Lactosyl-b-1,1'-N-octanoyl-L-threo-sphingosine is a glycosylation agent that is used in the synthesis of complex carbohydrates. This compound has been shown to be stable in aqueous solutions and can be used for the modification of saccharides, oligosaccharides, and polysaccharides. Lactosyl-b-1,1'-N-octanoyl-L-threo-sphingosine is also useful for the fluorination of sugars. The CAS number for this compound is 939036-94-9.

A GalNAc trisaccharide

Trehalose 6-tetradecanoate is a custom synthesis of an oligosaccharide that is modified by methylation, glycosylation, and carbamylation. It is a polysaccharide that has been modified with click chemistry. Trehalose 6-tetradecanoate is a high purity product that can be used in the synthesis of other compounds.

Applications Kanamycin A (K137500) derivative.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Applications A labelled metabolite of 1-Hydroxypyrene, which is found in human urine after exposure to coal tar and a coal derived product. References Jongeneelen, F.J., et al.: Int. Arch. Occup. Environ. Health, 57, 47 (1985)

Stability Hygroscopic Applications Labelled Cytarabine, a compound used as an antineoplastic and antiviral. A selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis. References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

G-NGA2F N-Glycan is a methylated, saccharide containing oligosaccharide. It is a custom-synthesized, high purity carbohydrate and sugar that can be modified with fluorination. G-NGA2F N-Glycan has been shown to have complex carbohydrate properties with a CAS No. of 84825-26-3.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Applications 1-O-n-Octyl-d17-beta-D-glucopyranoside (CAS# 129522-81-2) is a useful isotopically labeled research compound.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Neutral pentasasaccharide naturally present in human breast milk

Sunset Yellow FCF (Sunset yellow) is an orange azo dye with pH-dependent absorbance.Sunset Yellow FCF is used in food, cosmetics and pharmaceuticals.It is used

Applications Daunorubicin (D194500) impurity. Daunomycin analog antitumor. References Cassinelli, G., et al.: J. Antib., 38, 856 (1985), Arcamone, F., et al.: J. Med. Chem.,18, 703 (1975),

a-Maltotetraosyl-a,a-trehalose is a carbohydrate that is modified with fluorine. It is a complex carbohydrate with four maltotriose units linked by alpha,alpha-trehalose units. This compound can be custom synthesized and has high purity. It can also be methylated and glycosylated. Click modification can be done to the sugar in order to modify its properties.

Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. A number of publications have suggested that agaroheptaose has properties that include: anti-microbial, antiviral, prebiotic, anti-tumoral, immunomodulatory, anti-inflammatory, glucosidase inhibitory, and hepatoprotective properties.

PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.