Carbohydrates and glycoconjugates

Anti-CD86 Antibody-Biotin (2N108) is a Biotin-conjugated Rabbit antibody targeting CD86. Anti-CD86 Antibody-Biotin (2N108) can be used in ELISA.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-cellobiosyl fluoride is a glycosylation product of cellobiose. It has been synthesized by the Click reaction between 2,3,6,2',3',4',6'-hepta-O-acetyl-a-D-cellobiosylamine and ethylene oxide. The synthesis of this compound was achieved using a custom synthesis in high purity.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

The Lipid A moiety of lipopolysaccharide forms the outer monolayer of the outer membrane in most Gram-negative bacteria. Escherichia coli lipid A is synthesized on the cytoplasmic side of the inner membrane by a conserved pathway of nine constitutive enzymes. Following attachment of the core oligosaccharide, nascent core-lipid A is flipped to the outer surface of the inner membrane by the ABC transporter MsbA, where the O-antigen polymer is attached. These complex glycoforms protect bacteria from antibiotics and complement-mediated lysis. The core and O-antigen domains are required for virulence and consequently are present in most clinical and environmental isolates (Raetz, 2007).

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

4-Aminobutyl 2-O-(a-D-mannopyranosyl)-a-D-mannopyranoside is a custom synthesis that has been fluorinated, methylated, and modified with a click modification. The product is a glycosylation that is an oligosaccharide sugar. It is an Oligosaccharide saccharide CAS No. Carbohydrate complex carbohydrate.

1,6,6'-Tri-O-tritylsucrose pentaacetate is a sugar that is synthesized by the process of fluorination and monosaccharide. It has a molecular formula of C12H18O9F. This compound can be used as a synthetic sugar in glycosylation reactions or as an Oligosaccharide for complex carbohydrate synthesis. The 1,6,6'-Tri-O-tritylsucrose pentaacetate can also be modified with methylation or click chemistry for high purity.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

3-O-(2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosyl)-1,2,4,6-tetra-O-acetyl-b-D-glucopyranose is an oligosaccharide that has been modified with a click modification. This compound is a complex carbohydrate and it is synthesized from a monosaccharide. 3-O-(2,3,4,6-Tetra-O-benzyl-a-D--glucopyranosyl)-1,2,4,6-- tetra--O--acetyl--b--D--glucopyranose is used in methylation reactions.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Applications Acetylgalactosaminidase sequence substrate Clostridium Bifidobacterium. A fluorescent substrate for α2,3-(O)-Sialyltransferase References Medina, M. et al.: Cancer Res. 59,1061-1070, (1999)

In plants and algae, the two main galactolipids, monogalactosyldiacyglycerol (MGDG) and digalactosyldiacyglycerol (DGDG), are synthesized by galactosyltransferases in the plastid envelope. They have been linked to the anti-inflammatory and cancer benefits of a green leafy vegetable diet in humans due to their ability to regulate the levels of free radicals like nitric oxide (NO)

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Galactofuranose pentasaccharide PEG6-NH-sp-biotin is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Galactofuranose pentasaccharide PEG6-NH-sp-biotin is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Applications Streptidine, is a metabolite derivative of Streptomycin (S687500), an antibiotic (antimycobacterial) drug, used for patients suffering from tuberculosis or other infectious diseases. References Granados, O., et al.: Histology and Histopathology, 20(2), 357 (2005);

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

a1-3 linked isomer of globotetraose

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Methyl a-D-laminaribioside is a modified glycosylation product of D-Laminaribiose. It is an oligosaccharide that has been modified with methyl and fluorine groups. The modification of the sugars with these functional groups increases the stability and solubility of the molecule. Methyl a-D-laminaribioside is used in research for its ability to be click modified, polysaccharides, or saccharides, as well as being used in synthetic chemistry as a sugar to modify other molecules. Methyl a-D-laminaribioside is also used in medicine as an anti-inflammatory agent. Methyl a-D-laminaribioside can be synthesized by custom synthesis and has CAS number 7115-19-7.

Anti-Kallikrein 3/KLK3 Antibody-Biotin (3P661) is a Biotin-conjugated Mouse antibody targeting Kallikrein 3/KLK3. Anti-Kallikrein 3/KLK3 Antibody-Biotin (3P661) can be used in ELISA.

Fully acetylated cellohexoses, part of a polymer homologous series of oligosaccharides isolated from cellulose by acetolysis followed by chromatography.

The core trisaccharide of the ganglioside GD2,protected with a propargyl glycoside group, is the most prominent alkynyl glycoside used in oligosaccharide synthesis (Das, 2016). The structure (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) of its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

Applications Cytidine 5’-Phosphate Methyl Ester Sodium Salt is an byproduct formed in the synthesis of analogs of Cytidine 5’-Diphosphate with an important role in the metabolism of phospholipids. References Trotter, P., et al.: J. Biol. Chem., 270, 6062 (1995), Janssen, M., et al.: Yeast, 16, 641 (2000), Henneberry, A., et al.: Mol. Biol. Cell, 12, 511 (2001), Boumann, H., et al.: Biochemistry, 42, 3054 (2003),

Methyl a-N-acetyllactosamine is a custom synthesis of Methyl a-N-acetylgalactosamine. This compound has been modified by fluorination, methylation, and click modification to yield the desired product. The monosaccharide structure was synthesized from the corresponding glycosyl halide and protected amino acid. The glycosylation reaction between this monosaccharide and the oligosaccharide containing an unprotected hydroxyl group yields the desired product. The purity of this compound is greater than 99%.

Hyaluronate biotin is a high purity, complex carbohydrate that has been modified with methylation and glycosylation. It has a molecular weight of 20kDa and is supplied as a powder. It is a white to off-white solid that can be dissolved in water or buffer solutions. This product can be used as an excipient in the manufacture of biologics such as vaccines, antibodies, enzymes, or other therapeutic proteins.

Hyaluronate rhodamine is a fluorescent dye that is used in molecular biology to visualize the distribution of intracellular glycoconjugates. It is a water-soluble, cationic dye that binds to negatively charged saccharides and glycosaminoglycans. The dye fluoresces when bound to these molecules, making it useful for detecting the distribution of glycoproteins in cells. Hyaluronate rhodamine can be used as a marker for carbohydrate-rich tissues such as cartilage, synovial fluid, and vitreous humor. This dye can also be used to detect glycoconjugates on the surface of cells and in extracellular spaces.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Methylation is the addition of a methyl group to a molecule. The mannobiose-BSA is a methylated derivative of mannobiose, which has been modified by adding BSA. The modification of mannobiose-BSA with BSA facilitates its use in glycosylation reactions and as an intermediate in the synthesis of other complex carbohydrates. Methylation is also used to modify saccharides, polysaccharides, and oligosaccharides. Methyl groups are typically added using an organic chemical called dimethylamine or using an enzymatic reaction with SAM-dependent methyltransferases.

A disaccharide

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Food additive; soil suspension polymer in detergents; thickening agent

Applications Labelled Uridine, a nucleoside; widely distributed in nature. Uridine is one of the four basic components of ribonucleic acid (RNA) References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Grakoui, A., et al.: J. Virol., 63, 5216 (1989); Strauss, J., et al.: Microbiol. Rev., 58, 491 (1994); Lin, Y., et al.: Virology, 292, 78 (2002);

Please enquire for more information about Difucosyllacto-N-tetraose including the price, delivery time and more detailed product information at the technical inquiry form on this page

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

1,3:1,4 b-Glucotriose (A) is a custom synthesis that is available with a purity of ≥98%. It is a fluorinated polysaccharide with a complex structure that can be modified to produce different variations. The methylation status of the compound can be customized as well. This product is an oligosaccharide and polysaccharide sugar that contains one glucose unit. It has been synthesized from the monosaccharide sugar and it can be used for chemical modification or for research purposes.

AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.

N-Acetylneuraminic acid-OVA refers to ovalbumin that has been conjugated with N-acetylneuraminic acid (Neu5Ac), a type of sialic acid. Sialic acids are important components of glycan structures and play various roles in biological processes, such as cell-cell interactions, immune response, and pathogen recognition. Conjugation of ovalbumin with N-acetylneuraminic acid can be used as a tool to study sialic acid-mediated biological phenomena or as an immunogen to elicit a specific immune response.

Applications A labelled nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) have been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. References Mullane, K., et al.: Trends Cardiovasc Med., 3, 227 (1993), Browne, G.J., et al.: J. Biol. Chem., 279, 13, 12220 (2004)

Heparin disaccharide III-A is a synthetic heparin that is modified with the addition of a sugar molecule. Heparin disaccharide III-A disodium salt (HDS) is a high purity, custom synthesized product and has been fluorinated to improve its stability. HDS has been shown to be an effective inhibitor of glycosylation in bacteria cells, leading to decreased production of bacterial enzymes and proteins. It also inhibits protein synthesis by preventing the methylation of ribosomes and reducing the number of saccharides available for glycosylation. The HDS molecule is composed of two sugars: N-acetylglucosamine and D-glucuronic acid. This compound also has anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Applications An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes. References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

Applications p-Nitrophenyl 2-Acetamido-2-deoxy-(4-O-2-acetamido-2-deoxy-β-D-_x000D_glucopyranosyl)-α-D-galactopyranoside is a compound useful in organic synthesis. References Medina, M. et al.: Cancer Res. 59,1061-1070, (1999)

Benzyl 4-O-(b-D-galactopyranosyl)-b-D-xylopyranoside is a synthetic monosaccharide that has been modified with fluorine. This compound is used to modify complex carbohydrates like glycosaminoglycans and glycoproteins. It is also used in the synthesis of oligosaccharides and polysaccharides, as well as in click chemistry. Benzyl 4-O-(b-D-galactopyranosyl)-b-D-xylopyranoside is available for custom synthesis, and can be ordered in high purity.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Fully acetylated cellohexoses, part of a polymer homologous series of oligosaccharides isolated from cellulose by acetolysis followed by chromatography.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Applications Labeled D-Ribose, which is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate. References Ostrowski, S., et al.: Science, 305, 71 (2004), Vavilin, D., et al.: Biochim. Biophys. Acta, 1708, 91 (2005), Fletcher, J., et al.: Anal. Chem., 79, 2199 (2007), Weissleder, R., et al.: Nature, 452, 580 (2008),

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Anti-Lipocalin-2/LCN2 Antibody-Biotin (5L150) is a Biotin-conjugated Rabbit antibody targeting Lipocalin-2/LCN2. Anti-Lipocalin-2/LCN2 Antibody-Biotin (5L150) can be used in ELISA.

Please enquire for more information about Kdo2-Lipid A ammonium including the price, delivery time and more detailed product information at the technical inquiry form on this page

Stability Hygroscopic Applications Used for the determination of galactose-6-sulphate sulphatase activity. Used in the diagnosis of Mucopolysaccharidosis IV A. References van Diggelen, O.P., et al.: Clinica Chimica Acta, 187, 131 (1987)

Anti-CD3 epsilon/CD3e Antibody-Biotin (5W730) is a Biotin-conjugated Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody-Biotin (5W730) can be used in ELISA.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

A 3-glucose cellulodextrin derived from cellulose degradation. An energy source for cellulosic bacteria. Can be used to help identify, differentiate and characterize oligosaccharide metabolizing enzymes such as endoglucanases and --glucosidases. Also useful in saccharification and ethanol fermentation research. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.