Carbohydrates and glycoconjugates

Man-6 Glycan, 2-AB labelled is a custom synthesis of mannose-6-phosphate, a monosaccharide. The molecule contains six carbons and one phosphate group. It can be modified with fluorination, methylation, or click modification. This glycan is synthesized by the addition of an oligosaccharide to a polysaccharide. Mannose-6-phosphate is an Oligosaccharide that carries out glycosylation reactions in the body. It is used as a precursor for other glycans such as N-Acetylglucosamine and N-Acetylgalactosamine.

Stability Hygroscopic Applications A macrolide compound which is known to have antibacterial activity, and is useful in the therapy of bacterial infections in mammals. Antibiotic. References Broto, P., et al.: Eur. J. Med. Chem., 19, 71 (1984), Farrar, V., et al.: J. Med. Chem., 36, 3517 (1993), Clark, D., et al.: J. Pharm. Sci., 88, 807 (1999),

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Rhamnose monohydrate (L-(+)-Rhamnose Monohydrate) is a naturally-occurring deoxy sugar that is found primarily in plants and some bacteria.

Applications A new acyl derivative of Tylosin (T947650) produced by microbial transformation. References Okamoto, R., et al.: J. Antibiotics, 33, 1300 (1980),

Stability Hygroscopic Applications Saikosaponin A was shown to exhibit anti-inflammatory activities by suppressing activation of NF-kB signaling pathway. References Wu, S.J., et al.: Am. J. Chin. Med., 38, 99 (2010); Wu. S.J., et al.: J. Med. Food., 11, 224 (2008); Yoon, S.S., et al.: Neurosci. Lett., 529, 97 (2012); Lu, C.N., et al.: Int. Immunopharmacol., 14, 121 (2012);

Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in PROTAC synthesis.

Sialyl Lewis X ceramide is a monosaccharide that belongs to the pentasaccharide group. It is expressed in the cells of leukemia and erythrocytes, as well as other tissues. Sialyl Lewis X ceramide is a hybrid molecule that has a backbone consisting of four sugar molecules and an amino acid sequence, with hydroxyl groups on one end and an acetyl glucosamine on the other end. The molecule has a carbohydrate skeleton consisting of galactose, glucose, mannose, and sialic acid. Sialyl Lewis X ceramide also interacts with selectins to mediate leukocyte-endothelial interactions in inflammation.

Applications Cardiotonic. Obtained by the O-methylation of Digoxin. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hunter, J., et al.: J. Biol. Chem., 268, 14991 (1993), Greiner, B., et al.: J. Clin. Invest., 104, 147 (1999), Jun, A., et al.: J. Pharm.Pharm. Sci., 4, 263 (2001), Sugiyama, D., et al.: Drug Metab. Dispos., 30, 220 (2002),

Please enquire for more information about Galb1-3GalNAcb1-4Galb1-4Glc including the price, delivery time and more detailed product information at the technical inquiry form on this page

Stability Hygroscopic Applications α-Glycosidase inhibitor. References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),

3,4,6-Tri-O-acetyl-2-O-(2,3,4-tri-O-benzoyl-a-L-fucopyranosyl)-D-galactopyranosyl trichloroacetimidate is a sugar. It is a complex carbohydrate that is a polysaccharide made up of three monosaccharides: D-, L-, and erythro-. This molecule has been fluorinated at the C3 position. The CAS number for this compound is 123787−06−1. 3,4,6-Tri-O-acetyl-2-O-(2,3,4-tri-O--benzoyl--a--L--fucopyranosyl)-D--galactopyranosyl trichloroacetimidate is custom synthesized and has high purity.

Non-reducing disaccharide; mildly sweet energy source; protein stabilizer

Monofucosyl (1-2)-iso-lacto-N-octaose II is an oligosaccharide that is found in human milk

2-O-(a-D-Galactopyranosyl)-b-D-fucopyranosyl propylamine is a glycosylated synthetic compound with a molecular weight of 726.2. It is an excellent substrate for the glycosylation of proteins and nucleic acids, as well as an excellent candidate for Click modification, fluorination, saccharide modification and custom synthesis. 2-O-(a-D-Galactopyranosyl)-b-D-fucopyranosyl propylamine is a high purity product available in bulk quantities.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Isomaltotriose is used as pharmaceutical intermediate. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

3'-Sialyl Lewis A-PAA-biotin is a carbohydrate that is used as a research tool for investigating the structure and function of glycoproteins, glycolipids, and glycosaminoglycans. It contains 3'-sialic acid linked to the terminal β-D-galactopyranosyl residue of a poly(amino acid) backbone. This product has been synthesized by custom synthesis and contains high purity with a custom synthesis.

4-Methoxyphenyl 2-acetamido-3,6-di-O-benzyl-4-O-[2,4-di-O-(3,6-di-O-(3,4,6-tri-O-(2,4,6,-triacetyl)-bDglucopyranosyl)-aDmannopyranosyl]-6-[2,4,-diO-(3,6,-diO-(3,4,-triacetyl)-bDgluco pyranosyl)aDmannopyranosyl]-aDmannopyranoside is a complex carbohydrate that belongs to the polysaccharides. The CAS number for this compound is 5243968. This compound has been modified by methylation and glycosylation. It is a sugar with high purity and fluorination. This compound has been synthesized by the click modification of a carbohydrate.

4-Methoxyphenyl 2,3,6-tri-O-acetyl-4-O-[2,4,6-tri-O-acetyl-3-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido)-bDgalactopyranosyl]-bDglucopyranoside is a modification of an oligosaccharide that has been synthesized by the Oligosaccharide Synthesis and Custom Synthesis Department at Acetech. This product is a complex carbohydrate with a high purity and CAS No. The carbohydrate chain is composed of a monosaccharide methylated at the 4 position and glycosylated with two polysaccharides (sugar) at the 1 and 3 positions. The saccharides are esterified with acetate moieties at the 2 positions. It contains fluorine atoms in the form of flu

4-O-(b-D-Ribofuranosyl)-L-rhamnopyranose is a custom synthesized monosaccharide that can be modified with fluorination and methylation. This sugar can be used for glycosylation reactions to form oligosaccharides or polysaccharides. The number of sugar molecules that are attached to the sugar determines the complexity of the carbohydrate. 4-O-(b-D-Ribofuranosyl)-L-rhamnopyranose is an example of a complex carbohydrate because it has four sugars attached to it.

Stability Hygroscopic Applications BB-K 6 is a semi-synthetic aminoglycoside antibiotic derived from Kanamycin A (K137500). References Naito, T. et al.: J. Antibiot., 26, 297 (1973); Cron, M.J. et al.: J. Chem. Soc. Chem. Comm., 6, 266 (1979); Nakagawa, S. et al.: Mircob. Drug Resist., 2, 269 (1979);

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Unusual lactose sulphate isolated from canine milk (beagle-Canis familiaris), which does not appear to have previously been isolated from milk or other natural sources. The structure was established by 2D NMR spectroscopy and mass spectrometry.

Acarbose EP Impurity F is an analytical impurity that is found in Acarbose EP, a drug product. Acarbose EP Impurity F is a synthetic compound and is not present in any natural products. The CAS number for this impurity is 83116-09-0. Acarbose EP Impurity F has been shown to be pharmacologically active in animal studies, but the specific activity of this impurity has not been determined. Acarbose EP Impurity F is used as an impurity standard in HPLC analysis of Acarbose EP and as a custom synthesis. Acarbose EP Impurity F may also be used as a research and development phase, niche product or as a drug development research compound.

3-Cyclohexylpropyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside is a solubilized form of epidermal growth factor (EGF) that binds to the epidermal growth factor receptor. It has been shown to stimulate epidermal growth and increase the rate of cellular proliferation in human epidermis. 3-Cyclohexylpropyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside may also have structural roles in mitochondrial matrix, ligand binding, and energy metabolism. Further study is needed to determine the role of this drug in these processes.

6-O-(2-Acetamido-2-deoxy-b-D-glucopyranosyl)-D-galactopyranose is a disaccharide that has been shown to have anti-inflammatory activities. It contains an acetamide group and a hydroxy group. The acetamide group is substituted by a hydroxy group, which may be responsible for its anti-inflammatory activity. 6-O-(2-Acetamido-2-deoxy-b-D-glucopyranosyl)-D-galactopyranose has also been shown to inhibit the production of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin beta (ILβ).

Stability Hygroscopic Applications Labelled Nicotinamide (N407750) analog. Nicotinamide riboside (β-NAR) is an intermediate in one biosynthetic pathway by which Nicotamide is converted into NAD (Nicotinamide Adenine Dinucleotide) References Friedlos, F., et al.: J. Biochem. Pharmacol., 44, 25 (1992), Ong, S., et al.: Biochemistry, 11210 (1992), Zhang, X., et al.: J. Biol. Chem., 278, 13503 (2003),

N-Acetylneuraminyl-(a2-3)-D-galactopyranosyl-(b1-3)-D-N-acetylgalactosaminyl serine is a custom synthesized carbohydrate with an average molecular weight of about 1,000. It has been modified with fluorination, methylation, and click chemistry. This polysaccharide has an acetamido group on the C6 position of N-acetylneuraminic acid and a glycosidic linkage at the C4 position of galactose. The saccharide units are composed of a 2,3-linked galactose residue and a b1,3 linked N-acetylgalactosamine residue. The CAS number for this carbohydrate is 116863-87-8.

Blend of sucrose esters with fatty acid esters from coconut oil used in Cosmetic industry applications.

Applications Vitamin B12-O5'-NHS Ester is a derivative of Vitamin B (V676005) which is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)

Benzyl 2-acetamido-2-deoxy-4-O-(b-D-galactopyranosyl)-a-D-glucopyranoside is a custom synthesis, complex carbohydrate. It is an Oligosaccharide, Polysaccharide that has been modified and glycosylated. It has a CAS number of 81243-70-1. This product's purity is high and it is fluorinated. The product is synthetic and contains sugar.

Produced by the reverse hydrolysis of a mannose substrate.  Isolated from the partial hydrolysates of bakers' yeast (Saccharomyces cerevisiae) mannan.  This disaccharide also forms the sugar portion of the phospholipid, phosphatidylinositodimannoside, of Mycobacterium tuberculosis.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Di-N-acetyl-D-lactosamine (DNL) is a sugar that is found in the mammalian tissues and can be used as a lectin to specifically bind to glycoproteins. It has been shown to have specificities for enteritis, and can be used to detect or analyze the sequences of oligosaccharides. DNL has been immobilized on silica gel, which was then reacted with lectins, such as concanavalin A, wheat germ agglutinin, and soybean agglutinin. This process allows for the detection of high-mannose-type oligosaccharides.

1,4-B-D-Xylotriitol is a synthetic carbohydrate that has been modified with fluorine. The use of the methylation reaction enables the synthesis of oligosaccharides with up to six glucose units. This product is available in high purity and can be custom synthesized to meet specific needs. 1,4-B-D-Xylotriitol is used for glycosylation reactions and may be useful for modifying carbohydrates and saccharides.

Applications Labelled Ouabain (O714500). A cardiac glycoside that inhibits Na(+)/K(+) ATPase. It regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Padilha, A.S. et al.: Clin. Exp. Pharmacol. Physiol., 35, 801 (2008); Blaustein, M.P. et al.: Clin. Exp. Hypertens. 20, 691 (1998); van Huysse, J.W. et al.: Clin. Exp. Hypertens. 20, 657 (1998);

Oligosaccharide domain of monosialylated glycosphingolipid GM1 with an α1,2-fucosylated galactose at the nonreducing end. The moluecule is minimally expressed in healthy tissues but has high prevalence in some tumours such as small cell lung cancer (SCLC). Fucosyl-GM1 ganglioside is a potential tumour marker for SCLC and a potential antigen target for immunotherapy.

3-(a-D-Rhamnopyranosyl)-D-glucose is a glycosylation product that is synthesized by the methylation of glucose. It is a complex carbohydrate with a high purity, CAS number and custom synthesis. 3-(a-D-Rhamnopyranosyl)-D-glucose has been modified by fluorination and click chemistry to produce a versatile reagent for glycosylation reactions.

Applications Desacetyllanatoside C is a derivative of Lanatoside C (L173800), glycosides isolated from various species of Digitalis. Cardiotonic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Novotny, J., et al.: J. Biol. Chem., 258, 14433 (1983), Farr, C., et al.: J. Med. Chem., 45, 3257 (2002), Van Dongen, M., et al.: Drug Discov. Today, 7, 471 (2002),

Stability Hygroscopic Applications Isotope labelled analogue of (-)-Inosine (I661000), compound that exhibits neuroprotective properties by improving axonal wiring and has also been used to treat stroke patients to restore neural function. References Vandemeulebroucke, A., et al.: Biochem., 49, 8999 (2010), Nestor, G., et al.: J. Agric. Food Chem., 58, 10799 (2010),

N-Acetyl-D-lactosamine ethyl fluorescein 5-thiourea is a carbohydrate that is custom synthesized by our company. It is a high purity, methylated, glycosylated, and fluorinated compound. This compound has CAS number 476-02-8. N-Acetyl-D-lactosamine ethyl fluorescein 5-thiourea is used in the modification of saccharides and oligosaccharides to study their interactions with enzymes such as glycosidases and nucleases.

Please enquire for more information about 1,3:1,4-b-Glucotetraose (B) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Applications 4-Methylumbelliferyl 4-Deoxy-β-D-chitobiose Peracetate (cas# 1228931-52-9) is a compound useful in organic synthesis.