Carbohydrates and glycoconjugates

4-O-(2-O-Methyl-b-D-galactopyranosyl)-D-glucopyranose is a disaccharide. The lacto-n-biose unit is a nonreducing sugar that contains an alpha, beta unsaturated 1,6 glycosidic bond and a lactose molecule. 4-O-(2-O-Methyl-b-D-galactopyranosyl)-D-glucopyranose has been found to stimulate the synthesis of galectin in vitro, which may be due to its ability to bind to lectins. This disaccharide can also cause denaturation at high temperatures.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

D-Sorbitol: natural & synthetic sweetener, half as sweet as sucrose, used in meds, manufacturing, research, and as a laxative.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Nigerotriose is a monosaccharide that belongs to the family of neutral oligosaccharides. It is found in plants, fungi, and bacteria. Nigerotriose has been shown to stimulate mitochondrial biogenesis through the activation of protein kinase A and glycogen synthase kinase-3beta. This activity has been demonstrated using a magnetic resonance spectroscopy technique. Nigerotriose also shares structural similarities with other molecules, including isomaltose oligosaccharides, which are effective disinfectants. However, the molecular weight of nigerotriose makes it less reactive than its isomaltose counterpart. The effective dose for nigerotriose has not yet been determined.

Useful oligosaccharide-lipid conjugate for raising antibodies.

Applications 3-(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione is an impurity of Zidovudine (A825000). Zidovudine is an antiviral agent used in the clinical treatment of HIV infections. References Radatus, B.K., Org. Process. Res. Dev., 15, 1281 (2011)

Anti-CD3 epsilon/CD3e Antibody (5W730) is a Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (5W730) can be used in WB,ELISA.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Sodium alginate is the sodium salt of a polysaccharide obtained from brown seaweeds. The main use for alginate is in textile printing as a thickener in the printing of cottons with reactive dyes. In the food industry it is used as a thickener and gelling agent. The chemical structure consists of blocks of (1,4) linked-β-D-polymannuronic acid (poly M), (1,4) linked-α-L-polyguluronic acid (poly G) and alternating blocks of the two uronic acids (poly MG).

Methyl 2-acetamido-4-O-(2-acetamido-2,3-dideoxy-b-D-glucopyranosyl)-2,6O-(a,L-fucopyranosyl)-b-D-glucopyranoside is a synthetic carbohydrate. It is a high purity and custom synthesis product with CAS No. 97242-84-7. This product has been fluorinated and methylated as well as glycosylated and click modified to increase its stability.

BMS309403 is a potent and selective inhibitor of adipocyte fatty acid binding protein aFABP.Cost-effective and quality-assured.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Pidotimod is a synthetic dipeptide with immunomodulatory properties.

Heparin derived dp18 saccharide ammonium salt is a complex carbohydrate that has been modified with methylation, custom synthesis, click modification, and fluorination. It is used as an anticoagulant to prevent the formation of blood clots. Modification of the sugar chain on the heparin molecule can be achieved through either monosaccharide or polysaccharide substitution. The monosaccharides most commonly found in heparin are glucosamine and N-acetylglucosamine. The polysaccharides that can be found in heparin include chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparan sulfate. Heparin derived dp18 saccharide ammonium salt is a high purity product that has been modified to have a higher degree of efficacy for use in clinical applications. This product is available for purchase at a cost-effective price point.

DL-Mannitol is a osmotic diuretic, it may play a role in reducing off-target 68Ga-PSMA renal uptake

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Maltotriosyltrehalose is a sugar that is found in plants, fungi, and bacteria. It can be used as a substrate for the production of hydrogen-bonded oligosaccharides. Maltotriosyltrehalose has been shown to have a protective effect against death induced by high temperatures in mammalian cells. This sugar is also a good substrate for the production of hydrogen-bonded oligosaccharides and can be used as an additive to dry food products such as bread or cereals. Maltotriosyltrehalose is stable at high temperatures and has been shown to protect against cell death caused by heat stress. It can be used in both animal feed and human food products. Maltotriosyltrehalose is not active against proteases, but it does not inhibit the activity of mammalian cells that produce proteases.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

2-Acetamido-4-O-(2-acetamido-2-deoxy-a-D-glucopyranosyl)-2-deoxy-D-galactopyranose is a Custom synthesis of an oligosaccharide that is synthesized by the modification of natural sugars. This product has been fluorinated, methylated and modified with click chemistry. It is saccharide consisting of two monosaccharides, which are 2 acetamido 4 O-(2 acetamido 2 deoxy a D glucopyranosyl)-2 deoxy D galactopyranose and 2 deoxy D galactose. The molecular weight of this compound is 528.5 g/mol.

The compound is a custom synthesis of a complex carbohydrate. It is an oligosaccharide with CAS No. and polysaccharide that has been modified by methylation, glycosylation, and click modification. The compound is Methylated, Glycosylated, Click-modified Carbohydrate Sugar with high purity and fluorination.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Glycyl-sialyllacto-N-tetraose a is a custom synthesis that is an oligosaccharide with a molecular weight of 471. It has the CAS No. of 882859-14-6 and can be modified by methylation, glycosylation, and fluorination. This saccharide is a polysaccharide that can be modified by glycosylation, methylation, and click modification. The carbohydrate has a high purity and can be synthesized using organic chemistry or biochemistry techniques. Glycyl-sialyllacto-N-tetraose a is an Oligosaccharide with a sugar composition of (1) D-Glyceraldehyde 3-phosphate (2) D-Sorbitol 3 phosphate (3) Lactose (4) Glycyl-(1→4)-β--D--Galactopyranosyl-(1→3)-α

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Sodium alginate is a soluble fiber that is extracted from brown seaweed. It is a natural carbohydrate that can be modified to create a variety of sugar-based derivatives, such as Oligosaccharides, Monosaccharides, and Custom Synthesis. Sodium alginate has been modified with Fluorination, Methylation, Glycosylation, and Click Modification to create high-purity products for various applications.

Galα(1-3) N-glycan is a glycoconjugate that is an oligosaccharide with a galactose residue at the nonreducing end of the glycan. It has been synthesized using Click chemistry to introduce fluorination and methylation. Galα(1-3) N-glycan is an important model for studying the biological function of glycosylations in humans. It has also been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. This product is custom synthesis, high purity, and CAS No. 115973-45-0.

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Man-3a N-Glycan is a N-linked oligosaccharide with a trimannosyl core

Pentagalacturonic acid (α-1,4 galacturonopentaose) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate and characterize endo- and exopolygalacturonase(s) and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, tetra-galacturonate, and penta-galacturonate oligosaccharides, restores development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).

Impurity Clindamycin Phosphate EP Impurity F Applications Lincomycin 2-Phosphate (Clindamycin Phosphate EP Impurity F) is the derivative of Lincomycin (L466200), a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial. References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

4-Methoxyphenyl 4-O-(4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-3,6,2′,4′″triphosphate (4MPP) is a methylated saccharide. It can be modified with click chemistry and has been shown to inhibit the synthesis of glycogen in the liver. 4MPP is a high purity product that has been synthesized from naturally occurring carbohydrates. It is also fluorinated for use in research.

The 6-deoxy-6-fluorocyclomaltoheptaose is a low molecular weight compound that has been found to have anti-amylase activity. This substance is characterized by its chromatographic techniques, which can be used to identify the chemical structure of the molecule. The 6-deoxy-6-fluorocyclomaltoheptaose has been found to consist of an amylase inhibitor and an enzyme substrate. It exhibits specificity for the catalytic site of amylase, which is located in subsite 1, and it attacks this substrate at the 6-position of glucose. This substance is not as potent as other amylase inhibitors such as d-glucose, but it does show greater specificity for amylase than other substances with similar structures.

Hyaluronate Rhodamine is a synthetic, high-purity, fluorescent dye that can be used in the study of glycosylation and sugar modifications. It is a carbohydrate modified by methylation and fluorination. Hyaluronate Rhodamine has a molecular weight of 250kDa. The sugar component of the molecule is composed of an oligosaccharide with a saccharide repeat unit of 1-3 linked to a polysaccharide chain, which has been modified by methylation and glycosylation.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

GQ1b ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, two sialic acids (NeuAc) linked α2,3/α2,8 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Anti-GQ1b ganglioside antibody is associated with Miller Fisher syndrome and is also found in patients with related conditions that may share the same pathogenic mechanism, such as, Bickerstaff brainstem encephalitis. Thus, the measurement of the anti-GQ1b antibody in suspected cases of Miller Fisher syndrome is a useful diagnostic marker (Paparounas, 2004). It has been found that GQ1b ganglioside contributes to synaptic transmission and synapse formation. Low concentrations of GQ1b ganglioside, evoked dopamine (DA) release from laboratory tissues (Chen, 2018).

6-O-Benzoyl-1,2,3-tri-O-benzyl-4-O-(2,3,4,6-tetra-O-benzyl-a -D-galactopyranosyl)-b -D -galactopyranoside is an oligosaccharide that has been custom synthesized by our company. It is a complex carbohydrate with a molecular weight of 1,216. The CAS number for this product is 105838-36-5. This product also has a high degree of purity and can be used in Click modification and Modification reactions. 6 O Benzoyl 1 2 3 tri O benzyl 4 O

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

2-AB labelled A1F Glycan is a complex carbohydrate. It is custom synthesized and high purity. The CAS number for this compound is 12863-00-8.

3'-Sulfated Lewis X sodium salt is a synthetic carbohydrate with a sulfate group on the 3' position of the sugar. It is a selective blocker of E-selectin, a type of selectin that plays an important role in inflammation and tissue injury. The binding site for 3'-sulfated Lewis X sodium salt is the cavity at the end of the selectin molecule, which has a hydrophobic region. This cavity can be blocked by hydrophobic moieties such as sulfates, fatty acids, or steroids. 3'-Sulfated Lewis X sodium salt has been shown to be effective in treating inflammatory conditions such as asthma and arthritis.

Anti-Pan Influenza A Nucleoprotein Antibody-Biotin (2Q691) is a Biotin-conjugated Rabbit antibody targeting Pan Influenza A Nucleoprotein. Anti-Pan Influenza A Nucleoprotein Antibody-Biotin (2Q691) can be used in ELISA.

SSEA-4 hexaose is a virulence factor that belongs to the lectin family. It has been shown to be activated by binding to lectins, which are proteins that bind carbohydrates. SSEA-4 hexaose has also been shown to have cytotoxic effects on cells and induce apoptosis in some cancer cell lines. This glycan is expressed in many tissues, including brain, heart, liver, kidney, erythrocytes, lymphocytes and monocytes. In addition, it binds specifically to clostridium perfringens and mycobacterium tuberculosis with high affinity.

Anti-IL-17 Antibody-Biotin (1W700) is a Biotin-conjugated Mouse antibody targeting IL-17. Anti-IL-17 Antibody-Biotin (1W700) can be used in ELISA.

Applications 2-O-(α-D-Glucopyranosyl)-D-galactose (cas# 7368-73-2) is a compound useful in organic synthesis. References Gent, P.A., et al.: J. Chem. Soc., 1, 1446 (1974)

L-Xylose (L-(-)-Xylose), a Xylose levo-isomer, is classified as the aldopentose type monosaccharide.

3'-Sialyllacto-N-neotetraose sodium is a synthetic, fluorinated oligosaccharide with a sialic acid side chain. This compound has been shown to be an inhibitor of lacto-N-neotetraose synthesis in the human gut. It is also used as a raw material for the synthesis of various complex carbohydrates and as a click modification reagent for saccharides and polysaccharides. 3'-Sialyllacto-N-neotetraose sodium can be modified at its methyl group or sugar moiety to produce desired products.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Meglumine (Meglumin), a derivative of sorbitol, is used in conjunction with iodinated organic compounds as contrast medium.

The product is a high purity, custom synthesis, sugar. It is fluorinated and glycosylated. The product has click modification and methylation. This product can be modified with a variety of reagents such as saccharide, oligosaccharide, and monosaccharide. The CAS Number for this product is [UL-13C6glc]Lactose monohydrate.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

N,N'-Diacetyl-3,6,3',4',6'-penta-O-acetyl-1-chlorochitobioside is a galactosyltransferase inhibitor. It prevents the enzymatic transfer of a sugar group from UDP-galactose to an acceptor molecule by binding to the enzyme. N,N'-Diacetyl-3,6,3',4',6'-penta-O-acetyl-1-chlorochitobioside inhibits the enzymatic galactosylation of glycoproteins in cells and has been shown to be effective against bacterial strains resistant to other antibiotics. This drug is also chemoenzymatically synthesized using enzymes and chemical reagents.

Heparin derived dp24 saccharide ammonium salt is a complex carbohydrate and a saccharide. It is used for the modification of polysaccharides and oligosaccharides. The compound has been shown to reduce blood coagulation by preventing the binding of calcium ions to thrombin, which then blocks the conversion of fibrinogen to fibrin. Heparin derived dp24 saccharide ammonium salt has high purity and can be custom synthesized with high quality. The compound is also methylated, glycosylated, or click-modified.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Sialyl Lewis X (SLeX) is a carbohydrate antigen, related to cell adhesion and it has been shown that inhibition of SLeX synthesis leads to decreased adhesion of trophoblast cells to endometrial epithelial cells (Collins, 2006). Sialyl Lewis X is displayed on the terminus of glycolipids that are present on the surface of white blood cells and it has been shown that SLeX has an important role in inflamation processes. The inital adhesion of white blood cells to a site of injury is mediated by E-selectins which are specific for SLeX. Cell-cell recognition between leukocytes and endothelial cells in blood is believed to occur in part through interactions between lectins and oligosaccharide ligands. SLeX is frequently expressed in human cancer cells and primary tumors. It has been demonstrated that SLeX was involved in the adhesion of tumor cells to vascular endothelium. The potential role of SLeX in the tumor metastatic process has been supported by several clinical studies (Liang, 2016).

Monosialyllacto-N-neohexaose is a postulated sugar that has been suggested to be a membrane potential stabilizer. It has been shown to have a linear response in analytical methods, such as mitochondrial membrane potential and glycosidic bond. Monosialyllacto-N-neohexaose has also been investigated for use in diabetic patients because it may help to improve the membrane potential of cells. This sugar has also been studied for use in colostrum and infant formula due to its ability to stimulate the production of TNF-α, which is important for immune system development.

Applications Cetirizine Lactose Ester is a lactose adduct of Cetirizine (C281100).

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

This compound is a sugar molecule that is used in the synthesis of complex carbohydrates. It can be custom synthesized to have a desired purity and monomer content. It is also an intermediate for the synthesis of other saccharides. This compound is fluorinated at the 6-position and glycosylated at the 2-position, which makes it water soluble. The CAS number for this compound is 58427-42-6.

The methylation of a glycosylation is an organic chemistry technique that can be used to modify the chemical structure of a carbohydrate. A glycosylation is the reaction between an alcohol and a sugar, which produces a glycoside. The addition of methyl groups at specific positions on the sugar molecule can lead to improved properties such as increased stability, increased solubility, or increased uptake by cells. This process has been shown to produce compounds with more desirable pharmacological properties than their parent compounds. Click chemistry is a versatile and powerful method for modifying carbohydrates. It involves the use of copper-catalyzed azide-alkyne cycloaddition reactions to form carbon-nitrogen bonds in place of conventional amide linkages in peptides and proteins. Carbohydrates are modified using this method by attaching small molecules such as fluorine atoms onto one or more carbons in the carbohydrate structure. This process can be used to create novel sugars with improved properties including high purity, high stability

D-Galactopyranosyl-(b1-3)-[N-acetylneuraminyl-(a2-6)]-D-N-acetylgalactosaminyl serine-biotin is a Glycosylation, complex carbohydrate. It is a Methylation, Click modification, Polysaccharide. This product is Fluorinated.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human