Carbohydrates and glycoconjugates

Applications Labelled analogue of Tildipirosin, a novel 16-membered-ring macrolide used in veterinary medicine. Tildipirosin treat bacterial pathogens including Mannheimia haemolytica and Pasteurella multocida that cause respiratory tract infections in cattle and swine. References Rose, M. et al.: J. Vet. Pharmacol. Ther., (2012); Anderson, N.M. et al.: Antimicrob. Agents. Chemother., (2012);

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

4-Methoxyphenyl 2,3,6-tri-O-benzyl-4-O-(2,3-di-O-benzyl-b-D-galactopyranosyl)-b-D-glucopyranoside is a synthetic carbohydrate. It is made up of a saccharide and a sugar. This chemical has been fluorinated with the use of hydrogen fluoride gas. The chemical also has methyl groups that have been added to it. The chemical is highly pure and was custom synthesized for this project. This chemical can be used in glycosylation or click chemistry.

4-Aminophenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-b-D-thioglucopyranoside is a custom synthesis that has been fluorinated and methylated. This modified saccharide has been synthesized from a monosaccharide and an oligosaccharide with the help of click chemistry. The CAS number for this product is 60515-61-9.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Applications Adenosine receptors are related to many diseases such as cardiovascular, autoimmune, and cancer. CGS 21680 is a potent and selective agonist of the adenosine A2A receptor, a member of G protein coupled receptor (1,2,3). References (1) Jones, K. R., et al.: Sci Rep. 7, 44816 (2017) (2) Hutchison, A. J., et al.: J. Pharm. Exp. Ther. 251, 47 (1989) (3) Hasko, G., et al.: Nat. Rev. Drug Discov. 7, 759 (2008)

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

2,2',2''-Triaminotriethylamine-bis(thiogalactopyranosyl acetamide) is a fluorinated sugar that can be used as a building block in glycosylation and oligosaccharide synthesis. It has been shown to be useful for the preparation of complex carbohydrates with desired properties such as high purity.

Tri-mannuronic acid sodium salt (b-1,4-linked sodium mannuronotriose) is one of a number of oligosaccharides obtained from alginate which is a polysaccharide in brown seaweeds containing: blocks of repeating mannuronic acid sequences (M-M-M-M etc), repeating guluronic acid sequences (G-G-G-G etc), and alternating M-G-M-G sequences.Oligosaccharides can be released using several methods (Lua, 2015; Yanga, 2004) and claims have been published that mannuronic acid oligosaccharides for example, can be effective in the prophylaxis and treatment of Alzheimer's disease, or for the prophylaxis and treatment of diabetes (USP 8835403B2, 2014).

Stability Very Hygroscopic Applications Lactose-3’-sulfate (cas# 159358-51-7) is a compound useful in organic synthesis.

Disialylated pentaose type I (DSI-1) is a disaccharide sugar that is synthesized in high purity by custom synthesis. It is a complex carbohydrate that consists of five monosaccharides: glucose, galactose, mannose, fucose and N-acetylneuraminic acid. DSI-1 has been shown to have glycosylation and methylation activity. This product has been modified with fluorination and saccharide modification, as well as Click chemistry. Disialylated pentaose type I is used in the pharmaceutical industry as an intermediate for the production of glycoconjugates and in the food industry to produce artificial sweeteners.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Stability Hygroscopic Applications A metabolite of 6-Mercaptopurine. References Parker, W., et al.: Cancer Res., 51, 2386 (1991) , Munagala, N., et al.: J. Biol. Chem., 275, 37072 (2000), Guddat, L., et al.: Protein Sci., 11, 1626 (2002), Pinkel, D., et al.: J. Clin. Oncol., 11, 1826 (1993), Tripathy, D., et al.: Oncologist, 12, 375 (2007),

Galactosyllactose attenuated NF-κB inflammatory signaling in human intestinal epithelial cells and in human immature intestine. Thus, galactosyllactoses are strong anti-inflammatory agents in human colostrum and early milk, contributing to innate immune modulation. The potential clinical utility of galactosyllactose warrants investigation.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

2-Acetamido-2-deoxy-6-a-O-sialyl-D-galactopyranose is a monosaccharide that is synthesized from D-galactose and acetamide. It has a molecular weight of 388.13 and an empirical formula of C8H14N2O4. This product can be custom synthesized to meet the needs of customers, with a purity level of 98%. 2-Acetamido-2-deoxy-6-a-O-sialyl--D--galactopyranose is used in glycosylation reactions, as well as in the synthesis of oligosaccharides, sugar and saccharide derivatives. This product can also be used for fluorination reactions, methylation reactions, and click modification reactions.

Monosialylated glycosphingolipid with an α1,2-fucosylated galactose at the nonreducing end. The moluecule is minimally expressed in healthy tissues but has high prevalence in some tumours such as small cell lung cancer (SCLC). Fucosyl-GM1 ganglioside is a potential tumour marker for SCLC and a potential antigen target for immunotherapy.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Applications Digoxin derivative, a cardiotonic glycosides steroid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Yoshida, F., et al.: J. Med. Chem., 43, 2575 ( 2000), Turner, J., et al.: Pharm. Res., 21, 68 (2004), Wang, J., et al.: Anal. Chim. Acta, 601, 156 (2007),

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Anti-Lipocalin-2/LCN2 Antibody (5L150) is a Rabbit antibody targeting Lipocalin-2/LCN2. Anti-Lipocalin-2/LCN2 Antibody (5L150) can be used in ELISA.

Sialylated tetrasaccharide found in human milk, possible health benefits for the neonate by supporting resistance to pathogens, gut maturation, immune function, and cognitive development.

Core antigen fragment in ABO blood group system

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

D-Fructose (D-arabino-hexulose) , also known as D-(-)-Fructose or D-(-)-Levulose, is classified as a member of the Monosaccharides.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

6'-Sialyllactose-sp-biotin is a custom synthesis of a 6'-sialyllactose with a biotin moiety attached to the reducing end. The modification was done through fluorination, methylation, and monosaccharide synthesis. This product has CAS No. 1384441-62-6 and is an oligosaccharide saccharide that is polysaccharide containing glycosylated sugar. It is also a complex carbohydrate that contains many sugars in one molecule.

Monosialyllacto-N-hexaose is a high purity, custom synthesis sugar that belongs to the group of oligosaccharides. This carbohydrate is modified with fluorination and glycosylation, which are Click modifications. Monosialyllacto-N-hexaose has a CAS number of 68638-04-3. This product is available for purchase in bulk quantities.

6-O-(a-D-Galactopyranosyl)-b-D-thioglucopyranose is a complex carbohydrate that is used in the synthesis of oligosaccharides and polysaccharides. It can be modified with methyl groups, glycosylation, or click modification. This product has been fluorinated and is available in high purity.

2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-maltosyl bromide is a fatty acid that is isolated from the fungus Penicillium notatum. It has been shown to have anti-cancer properties by inhibiting cell proliferation and inducing cancer cell death by apoptosis. The mechanism of action has been shown to be due to its ability to inhibit the phospholipid membrane synthesis and disrupt the interaction between lipids and proteins in the membrane. This compound also inhibits the growth of cancer cells by binding with the hydroxyl group on the surface of cancer cells. 2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-maltosyl bromide has been shown to inhibit muscle cell proliferation in vitro and in vivo. This drug can be used as an alternative for treatment for cancer or other diseases that are caused by muscle

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Applications A DNA adduct from N-nitrosodiethanolamine and related β-oxidized nitrosamines. It is produced by nitrosamine bident carcinogens. References Wilson, V., et al.: Cancer Res., 48, 2156 (1988), Gorelick, N., et al.: Mutat. Res., 288, 5 (1993), Niedernhofer, L., wt al.: Chem. Res. Toxicol., 10, 556 (1997),

Anti-Her2/ERBB2 Antibody-Biotin (3Y105) is a Biotin-conjugated Rabbit antibody targeting Her2/ERBB2. Anti-Her2/ERBB2 Antibody-Biotin (3Y105) can be used in ELISA.

Isolated from ivory-nut mannan hydrolysates

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

NA4 is a n-glycan with an average molecular weight of about 3.5 kDa. NA4 is found in the blood and urine of human beings and other mammals, as well as in the milk from cows. It is a major component of mucus secreted by the respiratory tract, and it can be found in the outer layer of the skin. NA4 contains a single N-acetylglucosamine (NAG) residue at its reducing end.

Methyl 4-O-(2-acetamido-2-deoxy-b-D-galactopyranosyl)-b-D-galactopyranoside is a glycosylated, fluorinated oligosaccharide. The product has been modified with acetamidomethyl and 2,3,4,6'-tetraacetyl bromoacetate to produce the desired structure. This compound is used in synthesis of glycoproteins and carbohydrates for medical purposes. It is synthesized from high purity monosaccharides and custom synthesis for specific applications.

Eliglustat (Genz 99067) is an oral inhibitor of glucosylceramide synthase which is used in the therapy of type 1 Gaucher disease.

Core antigen fragment in ABO blood group system

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Iso-lactosamine HCl is a synthetic monosaccharide, glycosylation product of galactose and lactic acid. It is used in the production of oligosaccharides and complex carbohydrates. Iso-lactosamine HCl is a white powder that can be dissolved in water or ethanol.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Galactooligosaccharides (GOS) have a sweetness of 30-60 % relative to sucrose. They have applications in a wide range of food products such as sweeteners, bulking agents, and sugar substitutes and are found in a range of product types including bread, ‘sports’ drinks, jams, fermented milk, confectionary and desserts. In Europe they are incorporated into infant formula foods.

6'-Sulpho Lewisx-BSA is a complex carbohydrate that contains a saccharide moiety with a sulfated Lewisx epitope. It has been synthesized using click chemistry and modified with methylation and fluorination to yield the desired structure. The carbohydrate is of high purity and can be used in research as a model for glycosylation and glycosidic linkage. The carbohydrate also has properties that are analogous to those observed in glycoconjugates, such as antibodies and lectins.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Methyl 2-acetamido-2-deoxy-3-O-(a-L-fucopyranosyl)-b-D-glucopyranoside is a glycosylation product of the natural sugar, galactose. It is a synthetic compound that has been modified with methyl groups and fluorine to form an active pharmaceutical ingredient. Methyl 2-acetamido-2-deoxy-3-O-(a-L-fucopyranosyl)-b-D-glucopyranoside can be used as a monosaccharide or oligosaccharide in the synthesis of complex carbohydrates.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

A1 Glycan, 2-AB labelled is a custom synthesis of a complex carbohydrate. The carbohydrate is an oligosaccharide that has been modified with methylation and glycosylation. The carbohydrate has a CAS number and is a polysaccharide. It is modified with saccharide, methylation, and glycosylation. The carbohydrate has undergone click modification and fluorination and it is synthetic.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Lacto-N-fucopentaose II-GEL is a complex carbohydrate with a molecular weight of 11,000 Da. This product is not for human use and is intended for research purposes only. It should not be used in food or cosmetics.

b1-4-Galactosyl-Galactose-BSA is a carbohydrate, modification and saccharide that is an Oligosaccharide and sugar. It is custom synthesized and has high purity. This compound can be fluorinated, complexed, or methylated. It also contains glycosylation or click modification.

Applications 4-Nitrophenyl 2-Acetamido-2-deoxy-4-O-α-L-fucopyranosyl)-β-D-glucopyranoside (cas# 259143-52-7) is a compound useful in organic synthesis.