Carbohydrates and glycoconjugates

1,4-beta-D-xylohexaose is a sugar that belongs to the group of xylooligosaccharides. It is an enzymatic inactivator that binds to the enzyme hydrolase family. Xylooligosaccharides are found in plant cell walls, where they can be used as a carbon source by termites. 1,4-beta-D-xylohexaose has been shown to be most active against neutral ph, but it is not active against acidic ph. The enzyme hydrolase family is inhibited by binding with 1,4-beta-D-xylohexaose and this prevents hydrolysis of carbohydrates, which includes glycosidic bonds.br>br> 1,4-beta-D-xylohexaose has also been shown to be beneficial for sustainable agriculture practices as it inhibits enzymes that break down xylooligosaccharides

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

N-Acetyl-D-lactosamine heptaacetate is a synthetically produced, fluorinated monosaccharide that is used in the production of glycosylations and polysaccharides. N-Acetyl-D-lactosamine heptaacetate can be custom synthesized to meet your needs. This compound is a high purity product.

Stability Hygroscopic Applications An inhibitor of lysozyme, reverses myocardial depression and lessens norepinephrine requirements in Escherichia coli sepsis in dogs. References Lefer, A., et al.: Am. J. Physiol., 213, 492 ( 1967), Parrillo, J., et al.: J. Clin. Invest., 76, 1539 (1985), Mink, S., et al.: J. Mol. Cell. Cardiol ., 35, 265 (2003),

N-Acetyl-D-lactosamine-sp-biotin is an oligosaccharide that is synthesized by the condensation of N-acetylglucosamine and sphingosine. It is a complex carbohydrate that can be modified with fluorination, monosaccharide, and polysaccharides. N-Acetyl-D-lactosamine-sp-biotin has been shown to have a high purity and can be used in the synthesis of glycosylation, methylation, or click chemistry.

Methyl 4-O-[4,6-O-(benzylidene)-b-D-galactopyranosyl] b-D-galactopyranoside tribenzoate is a synthetic carbohydrate. It is an oligosaccharide that contains a complex carbohydrate. It is a high purity product and has been custom synthesized. The CAS number for Methyl 4-O-[4,6-O-(benzylidene)-b-D-galactopyranosyl] b-D-galactopyranoside tribenzoate is 59414-33-2. This product has been fluorinated and methylated. It also contains glycosylation and click modification.

Hyaluronic acid is a polysaccharide containing repeating disaccharide units of 1,3-N-acetyl glucosamine and 1, 4-glucuronic acid.  This tetrasaccharide and other enzymatically produced polymer homologs have been of value in the study of hyaluronic acid metabolism in both healthy and diseased tissues (Hascall, 2019).

Stability Store in Freezer Applications 2’-Nitrophenyl 2,3-Di-O-acetyl-β-D-xylopyranoside (cas# 162088-91-7) is a compound useful in organic synthesis.

D-(-)-Tartaric acid is used as a resolving agent in organic synthesis. It is used as a precursor for the preparation of its ester derivatives like D-tartaric acid diethyl ester, D-tartaric acid dimethyl ester and D-tartaric acid diiso-propyl ester. It finds application in the synthesis of chiral aziridine derivative, a common intermediate for the preparation of hydroxyethylamine class HIV protease inhibitors viz. as saquinavir, amprenavir and nelfinavir. It is widely used in the food industry as a beer foaming agent, for food acidity regulations and as a flavoring agent. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3-O-Methyl-4-O-(3-O-methyl-a-D-mannopyranosyl)-D-mannopyranose is a synthetic sugar that can be modified to synthesize various oligosaccharides, polysaccharides, and complex carbohydrates. This fluorinated sugar has been modified with methyl groups at the 3' and 4' positions. It can be used for fluoroamination of glycosylation, Click chemistry, or other modifications. 3OM4OM3OM is soluble in water and glycerol, making it ideal for use in biological experiments. The chemical name for this compound is O-(3′,4′-dimethoxytrityl)-β--D--mannopyranosyl) -α--D--mannopyranoside and its CAS Registry Number is 836896-81-1.

Stability Store Under Argon Applications Shown to be a functional affinity ligand for the separation of exo-(cellobiohydrolasees) and endo-(endoglucanases) acting cellulases. References Piyachomkwan, K., et al.: Carbohydrate Research, 303, 255 (1997)

Lipopolysaccharide (LPS) is a molecule that is produced by Porphyromonas gingivalis. This molecule is also found in the outer membranes of Gram-negative bacteria and has been shown to have many effects on animal tissues. LPS activates HIF-1α, which leads to the production of inflammatory cytokines such as necrosis factor (TNF), and interferon regulatory factors (IRFs). These molecules signal for the production of more LPS. LPS also causes tissue growth and development by activating growth factors such as insulin-like growth factor 1. LPS also activates immune cells through signaling with chemokine receptors, promoting inflammation.

Heparin is a glycosaminoglycan which is a complex carbohydrate that contains repeating disaccharide units of glucosamine and N-acetylglucosamine. Heparin has been shown to inhibit the activity of bacterial enzymes involved in fibrinolysis, such as plasminogen activator inhibitor 1 (PAI-1), and may act as an anticoagulant. Heparin is often used as an anticoagulant in patients with thrombotic disorders, including deep vein thrombosis, pulmonary embolism, or heart attack. Heparin also acts as a cofactor for the activation of clotting factors II (thrombin), VII, IX, X, XI and XII. In addition, it inhibits the activation of factor XIII by preventing its conversion from its inactive form into active factor XIIIa. The molecular weight of heparin is approximately 10 kilodaltons (kDa) and it has a molecular formula

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

1,5-α-L-Arabinotriose is a sugar that is found in the cell walls of plants. It is a trisaccharide composed of three units of D-glucose and one unit of D-xylose. The linkage between the two sugars is an α1,5 bond. 1,5-α-L-Arabinotriose has been shown to be adsorbed on cellulose acetate and can be used to measure the molecular weight of the adsorbate. This sugar also undergoes optical rotations when it interacts with some dyes such as germanium tetrachloride. 1,5-α-L-Arabinotriose has many uses including: as a solute in chloride ion chromatography; as an absorbent in filtration experiments; and as a parameter for calculating thermodynamics for reactions involving hydrogen transfer.END>

A tetra-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl)-b-D-thioglucopyranose is a 1,2,3,4 tetraol. It is synthesized by the modification of a disaccharide that has been modified with fluorine and methyl groups on the C1 and C4 positions of the sugar. The complex carbohydrate is a glycosylated sugar that is composed of one monosaccharide and one oligosaccharide. This product is CAS No. 1820574-50-2.

3-O-(b-D-Galactopyranosyl)-D-arabinose is a disaccharide sugar that is found in mammalian tissue and many other biological systems. It binds to fatty acids, which are important for the structure of cell membranes. 3-O-(b-D-Galactopyranosyl)-D-arabinose is also an important component of oligosaccharides and glycolipids. The binding constants for this sugar have been determined by both titration calorimetry and microcalorimetry. 3-O-(b-D-Galactopyranosyl)-D arabinose has been used as an antiviral agent against Leishmania spp., which is a parasitic protozoa that causes leishmaniasis, the third most common human parasitic disease. This compound has also been shown to inhibit the growth of microalgae, such as Chlorella sorokiniana.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).

k-carrageenan derived tetrasaccharide alcohol disulfate+(3-6 anhydrogalactose)

Trehalose is a sugar that is found in many organisms, including humans. It is a disaccharide composed of two glucose units. Trehalose has been shown to be effective against infectious diseases such as HIV and malaria. Trehalose may have anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). The water vapor pressure of trehalose dihydrate is higher than that of trehalose anhydrous, which may account for its greater stability under high humidity conditions.

Oligogalactosyllactose is a polysaccharide made from galactose and glucose. Oligogalactosyllactose has been shown to have an inhibitory effect on the growth of Staphylococcus aureus strains. Oligogalactosyllactose also has anti-inflammatory properties, which may be due to its ability to bind to free fatty acids and reduce the production of pro-inflammatory cytokines. This dietary ingredient is found in inulin, which is a type of carbohydrate that can be found in some vegetables. Oligogalactosyllactose is composed of short chains of sugar molecules, making it easier for the body to absorb. It is also more readily metabolized by bacteria in the gut than other types of carbohydrates like celluloses or starches.

Please enquire for more information about Robinose including the price, delivery time and more detailed product information at the technical inquiry form on this page

Trehalose-6-phosphate disodium salt is a complex carbohydrate that can be modified to create a variety of products. Trehalose-6-phosphate disodium salt is made by the methylation of sugar, which creates an alpha-D-glucopyranosyl unit. This product can be used in the synthesis of oligosaccharides and polysaccharides, as well as other carbohydrates. Trehalose-6-phosphate disodium salt is also fluorinated to produce trehalose 6 phosphate fluoride, which has properties similar to those of trehalose 6 phosphate.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Citric Acid Monohydrate: tricarboxylic, from citrus, antioxidant, stabilizes drugs, preservative.

b1-4 penta mannuronosaccharide-from alginate by enzyme or acid hydrolysis

Stability Hygroscopic Applications 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is a substrate for the lysosomal heparin sulphamidase. It is a fluorometric enzyme assay for the diagnosis of Sanfilippo disease type A (MPS IIIA). It is also a fluorogenic substrate for sulfamidase. References Karpova, E.A., et al.: J. Inher. Metab. Dis., 19, 278 (1996), Dasgupta, F., et al.: Carbohydrate Res., 337, 1055 (2002),

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Hyaluronate biotin is a complex carbohydrate that consists of a saccharide with a terminal sugar and methylated N-acetylglucosamine. The molecular weight of Hyaluronate biotin is 2500kDa. It can be synthesized by reacting the appropriate monosaccharides under the presence of an enzyme, such as glucose oxidase. This product has high purity and is modified using Fluorination and Click modification.

Stability Hygroscopic Applications An alkaloid from colchicine derivative. References Kintz, P., et al.: J. Anal. Toxicol., 1997, 21, 70 (1997), Shi, Q., et al.: J. Med. Chem., 40, 961 (1997),

2-Acetamido-6-O-(a-2-N-acetylneuraminyl)-2-deoxy-a-D-galactopyranosyl serine is a monosaccharide sugar that is the terminal sugar at the nonreducing end of the glycosidic linkage in gangliosides. It has been shown to be a marker for colorectal adenocarcinoma and may be used as a prognostic marker. 2-Acetamido-6-O-(a-2-N-acetylneuraminyl)-2-deoxy--aDgalactopyranosyl serine, along with other gangliosides, has been found to be elevated in maternal blood and human serum during bowel diseases such as ulcerative colitis. This molecule has also been shown to have structural similarities to antigens that are associated with infectious diseases such as malaria.

Anti-CTLA-4 Antibody (8I311) is a Mouse antibody targeting CTLA-4. Anti-CTLA-4 Antibody (8I311) can be used in ELISA,ELISA(Cap).

Paromamine is a chemical compound that inhibits protein synthesis by enzymatic inactivation. It has been shown to have a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria. Paromamine also has the ability to inhibit bacterial growth at high salt concentrations, making it an attractive candidate for development as an oral antibiotic drug. Paromamine is synthesized from natural products, such as salicylaldehyde or phenylhydrazine, which are readily available and inexpensive. The reaction mechanism for the formation of paromamine starts with dehydration of the hydroxyl group on the hydrazine to form a carbonyl group. This carbonyl group reacts with sephadex g-100 to form a cyanohydrin. The cyanohydrin reacts with ammonia to form an amide bond between the two nitrogen atoms in the molecule, which forms paromamine.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Dermatan sulphate decasaccharide ammonium salt is a synthetic, high purity, complex carbohydrate. The CAS number for this product is 543-58-2. Dermatan sulfate decasaccharide ammonium salt is a complex carbohydrate that has been modified with a fluorine atom at the C1 position of the glucose monosaccharide and an acetyl group at the C4 position of the glucuronic acid monosaccharide. Click chemistry was used to introduce these modifications on the sugar molecule and it has been found to be stable in both acidic and alkaline conditions. This product can be customized for your specific needs, including fluorination, methylation, or glycosylation at any position.

Isolated from partial acetolysate of ivory-nut (Phytelephas macrocarpa) mannan

Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.

Blood group antigen with spacer arm

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Disialyl-TF is a monoclonal antibody that binds to the CD33 antigen on the surface of all types of cancer cells, including breast cancer cells. Disialyl-TF has been shown to reduce the growth and spread of prostate cancer cells in mice, reducing tumor size and weight. Disialyl-TF is also active against infectious diseases such as HIV, which may be due to its ability to inhibit the expression of glycan receptors. The mechanism by which it works is not yet known. Disialyl-TF has been shown to bind with high affinity to erythrocytes bearing A or B blood group antigens, making it an excellent diagnostic tool for detecting these antigens in patients with acute myeloid leukemia or other cancers.

Globotriaosylceramide (Gb3) is a glycolipid that has been shown to be an activator of the protein growth factor-β1. It is involved in the regulation of tumor cell proliferation and may have potential as a biomarker for cancer. Gb3 is also a drug transporter and it has been shown to have long-term efficacy in the treatment of sarcoidosis. Gb3 has been found in high concentrations in patients with HIV infection, suggesting that it may play a role in HIV replication. Studies have also shown that Gb3 may be involved in cardiac pathology and its structural analysis can help in understanding its function. Symptoms or conditions associated with elevated levels of globotriaosylceramide include: • Carcinoma • Cardiac disease • Infectious diseases • HIV infection

This is a custom synthesis of 1,3,6-tri-O-acetyl-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-2-azido-2-deoxy--aDglucopyranose. This product is a synthetic oligosaccharide that has been modified to contain fluorine atoms at the C1 and C6 positions. It has a CAS number of 5243787 and is available in high purity. It is also an Oligosaccharide and Polysaccharide.

Biotin-labelled oligosaccharide domain of the monosialylated glycosphingolipid GM2 of a-series. The compound is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system. GM2 is also overexpressed in melanomas and other tumours of neuro-ecto origin. Moreover, the sugar moiety of this ganglioside is a receptor allowing viral infection of cells with reovirus and rotavirus.

3,4,2',3',6'-Penta-O-acetylsucrose is a deuterated analog of sucrose. It can be synthesized by reacting sucrose with acetyl chloride in the presence of a base. The transesterification reaction yields the desired product in an overall yield of about 20%. This process is similar to that used for the synthesis of fatty acid esters, but 3,4,2',3',6'-Penta-O-acetylsucrose does not exist in nature and cannot be found as a natural product. The X-ray crystallography studies show that 3,4,2',3',6'-Penta-O-acetylsucrose has a conformation different from that of 6-phosphate sucrose.

Sucralfate is a drug that is used to treat and prevent injury-related inflammation by forming a protective barrier on the lining of the stomach and duodenum. Sucralfate has been shown to be effective in the treatment of infectious diseases, such as viral or bacterial infections, and also for radiation enteritis and ulcerative colitis. Sucralfate may interfere with the absorption of other drugs, such as acyclic nucleoside phosphonates, which are used to treat HIV/AIDS. This drug has also been shown to have anti-inflammatory properties through inhibition of prostaglandin synthesis. Sucralfate has been shown to have anti-inflammatory properties through inhibition of prostaglandin synthesis.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Impurity Azithromycin EP Impurity B Applications Azithromycin B (Azithromycin EP Impurity B), is an impurity of Azithromycin (A927000), a semi-synthetic macrolide antibiotic, and related to Erythromycin A. References Langtry, H.D., et al.: Drugs, 56, 273 (1998),

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Shikimic Acid (Shikimate) is a tri-hydroxy cyclohexene carboxylic acid important in the biosynthesis that the shikimate pathway is named after it.

3'-Sialyl Lewis X 16-sp - biotin is a modified oligosaccharide that is synthesized by the addition of a sialic acid residue to the terminal position of the carbohydrate. This product has a CAS number and can be custom synthesized to meet specific customer requirements. 3'-Sialyl Lewis X 16-sp - biotin is an important glycosylation site for many proteins, including CD45 and CD47, which are present in erythrocytes and leukocytes respectively. It is also used as an important substrate for methylation reactions due to its susceptibility to S-adenosyl methionine. 3'-Sialyl Lewis X 16-sp - biotin is soluble in water and has a high purity. The structure of this oligosaccharide includes a complex carbohydrate composed of mono-, di-, tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-sac

Tagatose is a sweetener based on its properties as a monosaccharide, specifically a hexose.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

6-O-Sulfated Lewis X is a complex carbohydrate that contains a 6-sulfated Lewis X monosaccharide. It has been synthesized to have a high purity and stability. 6-O-Sulfated Lewis X is soluble in water and can be used as a synthetic building block for the synthesis of saccharides, polysaccharides, and oligosaccharides. The compound has been modified to have fluorination at the C6 position.