Carbohydrates and glycoconjugates

Heparin disaccharide II-H disodium salt is a complex carbohydrate with the chemical formula C3H6Na2O14. It has a molecular weight of 617.8 and a melting point of 204.5°C. The compound has been modified by methylation, glycosylation, fluorination, and click modification. It is a synthetic oligosaccharide with high purity and custom synthesis.

Heparin Disaccharide II-A Disodium Salt is a modification of heparin. It is an oligosaccharide with a molecular weight of about 2,000 Daltons. This product can be custom synthesized as per the requirement of the customer. The purity level of this product is very high and it has been shown to have antiviral, anticoagulant, anti-inflammatory, and anticlotting properties.

Lactose-6'-phosphate is a sugar phosphate

GM1 pentasaccharide (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with a single sialic acid residue linked α2,3 to the inner galactose residue (Ledeen, 2009). GM1 pentasaccahride is the carbohydrate moiety of GM1 ganglioside. GM1 ganglioside interacts and modulates tyrosine kinases, such a,s neural tropomyosin receptor kinase A (TrkA), by inducing the release of neurotrophins from fibroblast cells and the epidermal growth factor receptor (EGFR) (Higuero, 2009). GM1 ganglioside is also found in epithelial membranes; it is a key element for bacterial toxicity and viral infection as it acts as a receptor for the B-subunits of heat-labile toxin, cholera toxin, rotavirus, and simian virus 40. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

i-Inositol (myo-Inositol) is a intracellular phosphate compound, involved in cell signaling and may stimulate tumor cell differentiation.

Synthetic building block for oligosaccharide synthesis

Please enquire for more information about A1F N-Glycan including the price, delivery time and more detailed product information at the technical inquiry form on this page

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Galactosyllactose attenuated NF-κB inflammatory signaling in human intestinal epithelial cells and in human immature intestine. Thus, galactosyllactoses are strong anti-inflammatory agents in human colostrum and early milk, contributing to innate immune modulation. The potential clinical utility of galactosyllactose warrants investigation.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Anti-N Antibody-Biotin (5A367) is a Biotin-conjugated antibody targeting N. Anti-N Antibody-Biotin (5A367) can be used in ELISA.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Applications Neomycin B-LP Acetate Salt Hydrate is a derivative of Neomycin (N389975) which is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.

Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. Reports have suggested that agaropentaose has neuroprotective properties.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

1,3,4,6-Tetra-O-acetyl-2-(2,3,4-tri-O-benzyl-a-L-fucopyranosyl)-a-D-galactopyranose is a methylated saccharide that has been synthesized to be used in the synthesis of complex carbohydrates. It is also called Tetra O Acetyl D Galactopyranoside. The chemical name of this product is 1,3,4,6 Tetra O Acetyl 2-(2,3,4 Tri O Benzyl A L Fucopyranosyl) A D Galactopyranose Methyl Ester. This product is also known as 6Fluoro 3 Indoxyl Beta D Galactopyranoside. This product can be custom synthesized to order and it can be modified based on customer specifications.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

D-Pantothenic acid sodium, a sodium salt of D-pantothenate, is a vital B5 derivative, aiding fat, carb, and amino acid oxidation.

Disialyloctasaccharide is a sialylated glycan that is found in human serum. It is a diagnostic marker for cancer, and has been shown to be elevated in women with breast cancer. Disialyloctasaccharide can also be used as a biomarker for depression. The amino acid sequence of this glycan has been determined, and it has been shown that the protein glycosylation of disialyloctasaccharide is quantified by measuring the relative amount of sialic acid residues in the molecule. Disialyloctasaccharide can be used as a biomarker for eukaryotes, including yeast and mammals. This glycan also has anti-tumor activity, which may be due to its ability to bind to receptors on tumor cells.

2-Methyl-(4-O-b-D-glucopyranosyl)-1,2-dideoxy-a-D-glucopyrano)-[2,1-d]-2-oxazoline is a custom synthesis of a carbohydrate. It can be modified by fluorination, methylation, and monosaccharide modification. It has been synthesized from a saccharide with a molecular weight of 803. This molecule has the CAS number 91433-96-7.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Tetrasaccharide associated with the glycolipid globoside

Erlose is a trisaccharide (b-D-fructofuranosyl-a-D-glucopyranosyl-(1,4)-a-D-glucopyranoside) found in royal jelly and honeys. Erlose has the same sweetening power as sucrose but is less cariogenic.

Applications Mannoheptulose occurs naturally in avocado fruit. It is used for normalizing insulin levels and reducing weight. References Lin, S., et al.: J. Biol. Chem., 265, 9670 (1990), Grimsby, J., et al.: Science, 301, 370 (2003), Matschinsky, F., et al.: Curr. Diabetes Rep., 5, 171 (2005), Matschinsky, F., et al.: Diabetes, 55, 1 (2006),

The structural analysis of chondroitin disaccharide di-0S sodium salt has been done by a bacterial enzyme, which is an enzyme that catalyzes the hydrolysis of glycosidic bonds. The reaction mechanism is spontaneous and the biochemical analysis indicates that the molecule is a glycosidic bond with hemiketal and hydration. The active site residues are found to be water molecule, which help in binding with the substrate to form a hemiketal. Biochemical analysis of this molecule reveals that it is an oligosaccharide with two sugar molecules linked by glycosidic bond.

Sialylglycan is a glycan that is found on the surface of cells and is important in cell-cell interactions. It is involved in the binding of influenza virus to its receptor, and sialylglycan has been shown to be bifunctional, meaning it can act as both an antigen and an antibody. Sialylglycan oligosaccharides are found in muscle tissue, which is where influenza viruses are most likely to attach. The molecule's fluorimetric properties have also been used to study outbreaks of avian influenza. Sialylglycan has been used for gene analysis by attaching fluorescent tags to the molecule that can be detected using fluorescence microscopy techniques. In vivo assays have also been performed with sialylglycan as a model antigen.

Tetra-O-benzyl-4-O-(2,3-di-O-benzyl-4,6-O-benzylidene)-a-D-mannopyranosyl)-b-D-glucopyranoside is a carbohydrate that has been modified with fluorination and methylation. It is a saccharide with an oligosaccharide group, which is attached to the 1-, 2-, 3-, 6-, and 4'-positions of the sugar. This product is synthesized by custom synthesis and is available in high purity. Tetra-O-benzyl-4-O-(2,3-di-O--benzyl--4,6--O--benzylidene)-a--D--mannopyranosyl)-b--D--glucopyranoside can be used as a glycosylation or click modification agent.

Gala1-3(Fuca1-2)Galb1-3GlcNAc

2,3,2',3',4',6'-Hexa-O-acetyl-1,6-anhydro-b-D-cellobiose is a synthetic monosaccharide. It can be modified with methylation, fluorination and click modification to produce 2,3,2',3',4',6'-hexamethylene-1,6-anhydro-b-D-cellobiose. This carbohydrate has been shown to have antiinflammatory activities in vitro and in vivo.

GM2-Oligosaccharide-spacer-NH2 ammonium is a complex carbohydrate with an oligosaccharide spacer and a hydrophobic NH2 group. The product is custom synthesized to your specifications and is available in high purity. It can be modified with fluorination or click chemistry. GM2-Oligosaccharide-spacer-NH2 ammonium is used in the synthesis of polysaccharides, saccharides, and carbohydrates. Some of its applications include modifying proteins, monosaccharides, and sugars.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Methylated glycans are carbohydrate-based molecules that are modified by the addition of a methyl group. These modifications can be used for many purposes, including as probes for enzymatic reactions and to block or enhance specific cell surface receptors. The modification is often done with a click chemistry reaction, which is a fast and efficient method that can also be used to modify other compounds such as proteins. Methylation of glycans is often done in the lab using methylamine gas, but it can also be accomplished through more complex methods like click chemistry or fluorination. Glycosylation is the process of adding sugars to other molecules and is one way to produce methylated glycans. Galactosamine (GalN) is an example of a monosaccharide that can be methylated and glycosylated, producing galactose-N-methyltransferase (Gal1MT) and Gal1M3GnT1. This product has been synthesized in

GQ3 oligosaccharide is the carbohydrate moiety in the GQ3 ganglioside. Breast cancer cells MCF-7 were found to express a complex pattern of neutral and sialylated glycosphingolipids from the globo- and ganglio-series, including unusual tetrasialylated and pentasialylated lactosylceramide derivatives, and GQ3 (II3Neu5Ac4-Gg2Cer) (Steenackers, 2012).

Stability Hygroscopic Applications Salicylic Acid 2-O-β-D-Glucoside (SAG) is the predominant glycosylated metabolite of Salicylic Acid (S088125); a compound that plays an important role in plants, mostly in the induction of systemic acquired resistance (SAR) against pathogens. References Huang, W.E., et al.: Plant J., 46, 1073 (2006)

Mixture of isomaltoses, commercially available in  food products such as protein/fiber bars, shakes, and other dietary supplements. Claimed as "prebiotic soluble fiber,” and/or as a “low‐calorie, low glycemic sweetener".

Neu5Troc[1Me,4789Ac]a(2-3)Gal[26Bn]-b-MP is a fatty acid that is localized in the microstructural component of the brain. The wild-type mice were given a diet containing Neu5Troc[1Me,4789Ac]a(2-3)Gal[26Bn]-b-MP and their brains were examined for changes in serotonin levels. Structural analysis showed that this fatty acid was not incorporated into serotonin receptors in the brain. Carbides were found to be responsible for the observed effects on serotonin levels.

Applications Isotope labelled D-glucono-1,5-lactone is the lactone derivative of D-gluconic acid. D-glucono-1,5-lactone is widely used as a food additive to achieve a curing, pickling or leavening effect. References Hidalgo, M.E., et al.: Int. J. Dairy. Technol., 65, 342 (2012); Li, F., et al.: Food. Hydrocolloids., 29, 347 (2012);

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

D-(+)-Cellobiose, a reducing disaccharide of two β-glucose units with a β(1→4) link, hydrolyzes to glucose.

An α-anomer, obtained by crystallization at low temperature, can be dehydrated to stable form above 130°C or an unstable (hygroscopic) form at lower temperatures. An example of the applications for α-Lactose monohydrate is in dry powder inhalers.  These are devices that deliver medication to the lung in the form of a dry powder generating an aerosol directly from the drug powder or mixture, using an excipient such as lactose monohydrate.

2,3,4,6-Tetra-O-acetyl-1-O-(2,3,4-tri-O-benzoyl-a-L-fucopyranosyl)-D-galactopyranoside is a glycosylated polysaccharide that has been modified by methylation and fluorination. It is synthesized from the monosaccharide D galactopyranose with a 2,3,4,6 tetra O acetyl group at the 1 position.

Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Please enquire for more information about Man-8D1D3 N-Glycan including the price, delivery time and more detailed product information at the technical inquiry form on this page

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

(24S)-24,25-Dihydroxyvitamin D3 undergoes various levels of hydroxylation to form active vitamin D3 analogs.

N-Fmoc-O-a-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-b-D-glucopyranosyl)-L-threonine is a synthetic sugar. It is an oligosaccharide that is used in the preparation of glycoproteins. It can be modified with fluorine and methyl groups for use in click chemistry reactions. NFAODTGLT has CAS number 539073-78-8 and molecular weight of 676.35. This product is available for custom synthesis with various modifications.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Anti-HIV-1 (group M, subtype B, strain 92418) p24 Protein Antibody-Biotin (8F825) is a Biotin-conjugated Mouse antibody targeting HIV-1 (group M, subtype B, strain 92418) p24 Protein. Anti-HIV-1 (group M, subtype B, strain 92418) p24 Protein Antibody-Biotin (8F825) can be used in ELISA.

Methyl b-N-acetyllactosamine is a sulfated glycosaminoglycan (GAG) that is expressed in the brain and is involved in the development of myelin. This compound has been shown to inhibit the transfer of sulfate groups, which are essential for the synthesis of GAGs. Methyl b-N-acetyllactosamine inhibits transglycosylation reactions, which is a process by which sugar moieties are transferred from one molecule to another. This inhibition results in decreased cross-coupling reactions and decreases the production of GAGs. Methyl b-N-acetyllactosamine has been shown to have potent inhibitory properties against sulfonylating enzymes, such as regiospecifically catalyzed sulfonylation and transglycosylation. It also has been shown to inhibit the transition state in an enzymatic reaction involving triazoles.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human