Carbohydrates and glycoconjugates

Applications A potent and selective inhibitor of NAE. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. The ubiquitin-proteasome pathway mediates the destruction of unwanted proteins. Potent NAE inhibitor; NEDD8 E1 Activating Enzyme Inhibitor. References Haas, A., et al.: J. Biol. Chem., 257, 10329 (1982), Walden, H., et al.: Nature, 422, 330 (2003), Kane, R., et al.: Clin. Cancer Res., 13, 5291 (2007), Saha, A., et al.: Mol. Cell., 32, 21 (2008),

Applications A histochemical substrate for a-N-acetyl-galactosaminidase. References Zhu, et al.: Gene, 137, 309 (1994)

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

The blood group B type III/IV tetrasaccharide is a synthetic, fluorinated carbohydrate that has been custom synthesized for glycosylation and methylation. The monosaccharide of the tetrasaccharide is a hexose, which can be modified with fluorine and click chemistry. The product is a complex carbohydrate with high purity and can be used in pharmaceuticals as an antigen for immunoglobulin G (IgG) production.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Anti-Her2/ERBB2 Antibody-Biotin (6Z596) is a Biotin-conjugated Rabbit antibody targeting Her2/ERBB2. Anti-Her2/ERBB2 Antibody-Biotin (6Z596) can be used in ELISA.

Raffinose is the most abundant of the family of oligosaccharides that are α-galactosyl derivatives of sucrose (Collins, 2006). The other main member of the group is the tetrasaccharide stachyose. Raffinose is found in sugar beet molasses and whole grains. Soybean oligosaccharides make up approximately 5% of dry matter in whole beans and up to 8% of dry matter in soybean meal. Together raffinose and stachyose rank second only to sucrose in abundance, as water-soluble carbohydrates (Kumar, 2010).

1,5-α-L-Arabinopentaose is a sugar that is found in plants. It inhibits the growth of bacteria by sequencing and binding to the enzyme L-arabinose isomerase, which converts L-arabinose to D-xylulose. 1,5-α-L-Arabinopentaose has been shown to have inhibitory effects on the metabolism of sugars in plants. This sugar binds tightly to immobilized enzymes and can be used for immobilization processes.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Man-7 Glycan is a synthetic, 2-AB labelled fluorinated monosaccharide. It is an oligosaccharide that is synthesized by the glycosylation of mannose and N-acetylglucosamine. This product has been modified with fluorination, methylation, and click chemistry.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Stability Hygroscopic Applications α-Glycosidase inhibitor. References Jefferies, I., et al.: Bioorg. Med. Chem. Lett., 7, 1171 (1997), Hassan, A., et al.: Carbohydr. Res., 339, 1565 (2004),

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Please enquire for more information about Lewis A tetrasaccharide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

NGA3 N-Glycan is a high purity, custom synthesis, sugar-containing glycoprotein. It is synthesized by Click modification of the glycopeptide backbone with a fluorinated amino acid and then glycosylated with an acetylated sugar. The acetylation of the sugar allows for selective labeling of the glycan. This product can be used in research applications such as Fluorination, Glycosylation, Synthetic, Methylation, Modification and Carbohydrate. It has CAS No. 110387-63-8 and is available in both Monosaccharide and Oligosaccharide form.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

Applications D-(+)-Trehalose is a disaccharide composed of two α-glucose units. D-(+)-Trehalose is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations. D-(+)-Trehalose is also used as a protein stabilize. This is the labeled analog. References Bosquillon, C. et al.: J. Cont. Rel., 99, 357 (2004); Arakawa, T. et al.: Adv. Drug Deliv. Rev., 46, 307 (2001); Singh, S.K. et al.: Pharmac. Res., 28, 873 (2011);

Applications Isotope labelled 1,5-Anhdyro-D-glucitol (A648000), a compound that has been isolated from several plant and animal sources, discovered in human cerebrospinal fluid and blood plasma and found to be an inhibitor of several enzymes. References Yamanouchi, T. et al. Am. J. Physiol. 263, E268 (1992); Yoshioka, S. et al. Clin. Chem. 30, 188, (1984); Field, R.A. et al. Bioorg. Med. Chem. Lett. 1, 667 (1991); Cavallaro, C.L. and Schartz, J. J. Org. Chem. 61, 3863 (1996).

1,5-α-L-Arabinohexaose is a carbohydrate. It is a nonreducing sugar that can be found in plants. 1,5-α-L-Arabinohexaose has an optimum pH of 5 and an ethanol concentration of 0.02%. The enzyme form of 1,5-α-L-Arabinohexaose is α-(1→6)-glycosidase. This enzyme hydrolyzes the α-(1→6) glycosidic bond between two glucose residues in a polysaccharide chain to produce β-(1→4) bonds. It also hydrolyzes the β-(1→4) glycosidic bond between two galactose residues to produce β-(1→2) bonds and oxidizes the terminal carbon atom to produce aldehyde products. A structural analysis of this carbohydrate was conducted using marine microorganisms and it was found that they contain galacturonic acid and sugar residues

Applications N-Acetyllactosamine derivatives were tested as acceptors for α1,3-L-Fucosyltransferase present in human ovarian cancer sera and ovarian tumor. References Lasky, L., et al.: Science, 258, 964 (1992), Hemmerich, S., et al.: Biochemistry, 33, 4830 (1994), Clarke, J., et al.: J. Biol. Chem., 271, 10317 (1996), Komba, S., et al.: Bioorg. Med. Chem., 4, 1833 (1996), Yoshino, K., et al.: J. Med. Chem., 40, 455 (1997),

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human

GalNAca1-3Galb1-3GalNAc

Used as enzyme substrates, analytical standards and for in vitro diagnostics

ABO trisaccharide conjugated to BSA via Biotin & an aminophenyl ethyl spacer

Anti-TIM-3/KIM-3/HAVCR2 Antibody (4H906) is a Rabbit antibody targeting TIM-3/KIM-3/HAVCR2. Anti-TIM-3/KIM-3/HAVCR2 Antibody (4H906) can be used in ELISA,ELISA(Cap).

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human