Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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10-Deoxo-9,10-dehydro Ketotifen
CAS:Controlled ProductFormula:C19H19NSColor and Shape:NeatMolecular weight:293.43(1S,4R)-4,6-Dihydroxy-1-(hydroxymethyl)-N-methyl-1,2,3,4-tetrahydroisoquinoline
CAS:Formula:C11H15NO3N-Ethyl Esmolol HCl
CAS:Formula:C15H23NO4·HClColor and Shape:White To Off-White SolidMolecular weight:281.35 36.461,2-Bis(2-aminoethoxy)ethane
CAS:Formula:C6H16N2O2Purity:>98.0%(GC)(T)Color and Shape:Colorless to Almost colorless clear liquidMolecular weight:148.212-OXAZOLIDINONE-5-SPIRO-4'-[N-(2-PHENYLETHYL)PIPERIDINE] HYDROCHLORIDE
CAS:Formula:C15H21ClN2O2Purity:98%Color and Shape:SolidMolecular weight:296.79244-Amino-6-chloro-1,3-benzenedisulfonamide
CAS:Controlled ProductImpurity Hydrochlorothiazide EP Impurity B Applications Diuretic. Hydrochlorothiazide EP Impurity B. References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Joshi, S., et al.: J. Pharm. Biomed. Anal., 52, 362 (2010), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),Formula:C6H8ClN3O4S2Color and Shape:White To Light BrownMolecular weight:285.734-Fluorobenzonitrile
CAS:Controlled ProductApplications 4-Fluorobenzonitrile is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wan, J. et al.: Org. Lett., 15, 2742 (2013); Kormos, C. et al.: J. Med. Chem., 56, 4551 (2013);Formula:C7H4FNColor and Shape:NeatMolecular weight:121.11Desacetyl Rifampicin Quinone
CAS:Controlled ProductStability Hygroscopic Applications Desacetyl Rifampicin Quinone is an impurity of Rifampicin (R508000). References Wilson, W.L. et al.: J. Chrom., 144, 270 (1977);Formula:C41H54N4O11Color and Shape:NeatMolecular weight:778.89Benzetimide HCl
CAS:Formula:C23H26N2O2·HClColor and Shape:White To Off-White SolidMolecular weight:362.47 36.46H-Phe-OtBu·HCl
CAS:Formula:C13H19NO2·HClPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:257.76(R)-3-Hydroxyisobutyric Acid Potassium Salt
CAS:Controlled ProductFormula:C4H7KO3Color and Shape:NeatMolecular weight:142.19D,L-O-Desmethyl Venlafaxine N-Oxide
CAS:Applications D,L-O-Desmethyl Venlafaxine N-Oxide is metabolite of the drug Venlafaxine (V120000(P)), which is a selective serotonin noradrenaline reuptake inhibitor and used as an antidepressant. References Klamerus, K. J., et al.: J. Clin. PHarmacol., 32, 716 (1992), Gelenberg, A.J., et al.: J. Am. Med. Assoc., 283, 3082 (2000)Formula:C16H25NO3Color and Shape:White To Off-WhiteMolecular weight:279.37[1-Hydroxy-1-Phosphono-2-[3-(trifluoromethyl)phenyl]ethyl]phosphonic Acid
CAS:Formula:C9H11F3O7P2Molecular weight:350.12Nafcillin-d5 Sodium Salt
CAS:Formula:C21H16D5N2O5S·NaColor and Shape:White To Off-White SolidMolecular weight:418.50 22.99Toremifene Citrate
CAS:Formula:C26H28ClNO·C6H8O7Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:598.091-Benzyl N-(tert-Butoxycarbonyl)-L-aspartate
CAS:Formula:C16H21NO6Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:323.35Ethyl (R)-(-)-3-Piperidinecarboxylate
CAS:Formula:C8H15NO2Purity:>98.0%(GC)Color and Shape:Colorless to Almost colorless clear liquidMolecular weight:157.21Ref: 4Z-C-2719
Discontinued productN-(2-Aminoethyl)maleimide Hydrochloride
CAS:Formula:C6H8N2O2·HClPurity:>93.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:176.601,1-Dibenzyl-4-[(5,6-dimethoxy-1oxo-2,3-dihydro-1H-inden-2-yl)methyl]piperidinium Bromide
CAS:Formula:C31H36NO3·BrN-Nitroso Varenicline
CAS:Controlled ProductApplications N-Nitroso Varenicline is a derivative of Varenicline (V215635(M)), which is a useful medication for smoking cessation. References Hart, E., et al.: Behavioural Brain Research, 397, 112887 (2021)Formula:C13H12N4OColor and Shape:NeatMolecular weight:240.2612,4-Di-tert-Butylphenol
CAS:Formula:C14H22OColor and Shape:White To Off-White SolidMolecular weight:206.33(alphaR)-alpha-[2-(1-Naphthalenyloxy)ethyl]benzenemethanol
CAS:Controlled ProductApplications (αR)-α-[2-(1-Naphthalenyloxy)ethyl]benzenemethanol is an impurity of Dapoxetine (D185700) which is a Selective serotonin reuptake inhibitor (SSRI). References Feret, B., et al.: Formulary, 40, 227 (2005),Formula:C19H18O2Color and Shape:NeatMolecular weight:278.34Des(1-cyclohexanol) Venlafaxine
CAS:Controlled ProductImpurity Venlafaxine EP Impurity A Applications Des(1-cyclohexanol) Venlafaxine (Venlafaxine EP Impurity A) is a Venlafaxine (V119995) impurity. References Basappa., et al.: Bioorg. Med. Chem. Lett., 14, 3279 ( 2004),Formula:C11H17NOColor and Shape:NeatMolecular weight:179.26Medroxyprogesterone Acetate Related Compound B (17-Hydroxy-6α-methylpregn-4-ene-3,20-dione)
CAS:Estrogens and progestinsFormula:C22H32O3Color and Shape:White PowderMolecular weight:344.23514LC-LC(+)-Biotin
CAS:Formula:C22H38N4O5SPurity:98%Color and Shape:SolidMolecular weight:470.62592000000006Proguanil Related Compound E (1-(4-chlorophenyl)-3-cyanoguanidine)
CAS:Nitrile function compounds, not elsewhere specified orFormula:C8H7ClN4Color and Shape:White Off-White PowderMolecular weight:194.03592Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nε-tetradecanoyl-L-lysine
CAS:Formula:C35H50N2O5Purity:98%Color and Shape:SolidMolecular weight:578.78192,2'-{Disulfanediylbis[ethane-2,1-diyl(4-hydroxybenzene-3,1-diyl)]}diacetic acid
Formula:C20H22O6S2Molecular weight:422.522,5-Dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanoate
CAS:Formula:C20H30N4O6SPurity:98%Color and Shape:SolidMolecular weight:454.54042'',3''-Bis-O-(Dichloroacetyl) Etoposide
CAS:Formula:C33H32Cl4O15Color and Shape:White To Off-White SolidMolecular weight:810.40Atorvastatin Epoxy Pyrrolooxazin Tricyclic Potassium Salt Impurity (>85%)
Controlled ProductApplications A photodegadation product of Atorvastatin (a cyclic impurity of Atorvastatin (A791750)), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia. References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),Formula:C33H32FKN2O6Purity:>85%Color and Shape:NeatMolecular weight:610.714(R)-Flurbiprofen
CAS:Controlled ProductApplications (R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Chalmers, et al.: Ann. Rheum. Dis., 31, 319 (1972), Nishizawa, et al.: Thromb. Res., 3, 577 (1973)Formula:C15H13FO2Color and Shape:NeatMolecular weight:244.26rac 4-Hydroxydebrisoquine Hemisulfate
CAS:Controlled ProductFormula:C10H13N3OH2SO4Color and Shape:NeatMolecular weight:240.27(R)-2-Despropionyl 2-Cyano Methadone((R)-Methadone Nitrile)
CAS:Controlled ProductApplications (R)-Methadone Nitrile is an intermediate in the production of Methadone. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gerber, N., et al.: J. Pharmacol. Exp. Ther., 200, 487 (1977), Brine, G., et al.: J. Pharm. Sci., 72, 700 (1983),Formula:C19H22N2Color and Shape:NeatMolecular weight:278.394-Ethynyltoluene
CAS:Formula:C9H8Purity:>97.0%(GC)Color and Shape:White or Colorles to Yellow to Orange powder to lump to clear liquidMolecular weight:116.16Leflunomide Related Compound A (4-(trifluoromethyl)aniline)
CAS:Toluidines (aminotoluenes) and their derivatives, salts thereofFormula:C7H6F3NColor and Shape:White Light Yellow LiquidMolecular weight:161.04523Paroxetine EP Impurity G (Paroxetine USP Related Compound E) as Hydrochloride
CAS:Formula:C12H14FN·ClHPhosphorus(1+), bromotri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)
CAS:Formula:C12H24BrF6N3P2Purity:98%Color and Shape:SolidMolecular weight:466.1812,6-Dichloroformanilide
CAS:Controlled ProductApplications 2,6-Dichloroformanilide is an intermediate in the synthesis of N-(2,6-Dichlorophenyl)-carbonimidic Dichloride (D436565). N-(2,6-dichlorophenyl)-carbonimidic Dichloride is an impurity of clonidine (C587130). Chlonidine is α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),Formula:C7H5Cl2NOColor and Shape:NeatMolecular weight:190.03D,L-Sulforaphane-L-cysteine
CAS:Controlled ProductFormula:C9H18N2O3S3Color and Shape:Light BrownMolecular weight:298.457-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
CAS:Controlled ProductApplications 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan (T536650). It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006)Formula:C18H15ClN2O4Color and Shape:NeatMolecular weight:358.784-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid
CAS:Formula:C9H5F3N2O2Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:230.15Valsartan Decarboxylic Acid
CAS:Controlled ProductFormula:C23H29N5OColor and Shape:NeatMolecular weight:391.5093Cocaine N-Methyl-d3
CAS:Controlled ProductApplications Inhibits the dopamine, norepinephrine, and serotonin transporters. Unlike amphetamines, it has no effect on catecholamine release. Controlled substance. Anesthetic (local). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Blakely, R.D., et al.: Curr. Opin. Neurobiol., 10, 328 (2000), Cowell, R. M., et al.: Eur. J. Pharmacol., 389, 59 (2000), Fleckenstein, A.E., Eur. J. Pharmacol., 406, 1 (2000), Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003),Formula:C172H3H18NO4Color and Shape:NeatMolecular weight:306.37Irinotecan-d10 HCl
CAS:Formula:C33H28D10N4O6·HClColor and Shape:Yellow SolidMolecular weight:596.75 36.468,14b-Dihydrooripavine
CAS:Controlled ProductApplications 8,14β-Dihydrooripavine is a Hydromorphone(H714650) impurity. Hydromorphone is an analgesic(narcotic). References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Zernig, G., et al.: Life Sci., 57, 2113 (1995), Keith, D., et al.: J. Biol. Chem., 271, 19021 (1996), Pawar, M., et al.: Eur. J. Pharmacol., 563, 92 (2007),Formula:C18H21NO3Color and Shape:NeatMolecular weight:299.36Tiopronin Dimer (Mixture of Diastereoisomers)
CAS:Formula:C10H16N2O6S2Color and Shape:White To Off-White SolidMolecular weight:324.37Bis(1-methylethyl) 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS:Formula:C21H26N2O6O-Desmethyl Tramadol Glucuronide (Mixture of Diastereomers)
CAS:Formula:C21H31NO8Color and Shape:White To Off-White SolidMolecular weight:425.484-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide Sodium Salt (Torsemide im
CAS:Stability Hygroscopic Applications An impurity of Torsemide.Formula:C13H11N3O3SColor and Shape:Off-White To Light YellowMolecular weight:311.29Fosinopril Related Compound H (4-phenylbutyl phosphonic acid)
CAS:Organo-inorganic compounds, nesoiFormula:C10H15O3PColor and Shape:White PowderMolecular weight:214.07588(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide
CAS:Controlled ProductStability Hygroscopic Applications (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide (cas# 1005450-55-4) is a useful research chemical.Formula:C22H20F3NOColor and Shape:White SolidMolecular weight:371.40N-Methyl-3-pyrrolidinyl Cyclopentylmandelate (mixture of diastereomers)
CAS:Controlled ProductFormula:C18H25NO3Color and Shape:Light Yellow OilyMolecular weight:303.40Tianeptine Sodium Salt
CAS:Formula:C21H24ClN2NaO4SPurity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:458.93Gadobutrol Trisodium Salt (Calcobutrol Trisodium Salt)
CAS:Formula:C18H31N4O9·3NaMolecular weight:447.47 3*22.99Fluticasone 17Beta-Carbonylsulfenic Acid 17-Propionate
CAS:Controlled ProductImpurity Fluticasone Propionate EP Impurity C / Fluticasone EP Impurity B Stability Hygroscopic Applications Fluticasone 17β-Carbonylsulfenic Acid 17-Propionate is an impurity of Fluticasone.Formula:C24H30F2O6SColor and Shape:White To Off-WhiteMolecular weight:484.55
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