Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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2-Bromo-1-cyclopropyl-2-phenylethanone (>85%)
CAS:Controlled ProductApplications 2-Bromo-1-cyclopropyl-2-phenylethanone is an impurity of Prasugrel (P701150), a thienopyridine antiplatelet agent.Formula:C11H11BrOPurity:>85%Color and Shape:NeatMolecular weight:239.11Caffeine-d9 (Pentoxifylline EP Impurity F-d9, Theophylline EP Impurity A-d9, Theophylline-Ethylenediamine EP Impurity A-d9)
CAS:Formula:C8HD9N4O2Color and Shape:White To Off-White SolidMolecular weight:203.254-Azido-2,2,6,6-tetramethyl-1-piperidinyloxy
CAS:Controlled ProductApplications An intermediate in the preparation of 4-Amino-2,2,6,6-tetra-methyl Piperidine-1-oxyl. References Li, W., et al.: J. Pharm. Pharmacol., 58, 941 (2006),Formula:C9H17N4OColor and Shape:Orange SolidMolecular weight:197.266-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
CAS:Controlled ProductApplications Intermediate in the preparation of Tyrosine Kinase Inhibitors. References Schroeder, M., et al.: J. Med. Chem., 44, 1915 (2001), Nandi, S., et al.: J. Enz. Inhibit. Med. Chem., 24, 937 (2009),Formula:C15H15N5O2Color and Shape:NeatMolecular weight:297.31Tamsulosin Sulfonic Acid
CAS:Formula:C20H27NO6SColor and Shape:White To Off-White SolidMolecular weight:409.505-Methyl-2-(1-methylethyl)phenol
CAS:Formula:C10H14OPurity:%Color and Shape:SolidMolecular weight:150.21762-Furoylglycine-d3
CAS:Controlled ProductApplications 2-Furoylglycine-d3 is the isotope labelled analog of 2-Furoylglycine (F865225); an intermediate used to prepare non-nucleoside inhibitors of HCV NS5b RNA polymerase. It is also used in the synthesis of benzimidazolylazabicyclooctylethylpiperidines as Ccr5 antagonists for the treatment of HIV infection. References Antonysamy, S., et al.: Bioorg. Med. Chem. Lett., 18, 2990 (2008); Kazmierski, W., et al.: PCT Int. Appl. (2004), WO 2004054974 A2 20040701Formula:C7D3H4NO4Color and Shape:NeatMolecular weight:172.15Tropatepine-13C-d3
CAS:Formula:CC21H20D3NSColor and Shape:White To Off-White SolidMolecular weight:337.503,4-Dehydrocilostazol (6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1H-quinolin-2-one)
CAS:Formula:C20H25N5O2D-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-,5-(1,1-dimethylethyl) ester
CAS:Formula:C24H27NO6Purity:97%Color and Shape:SolidMolecular weight:425.4743Rivastigmine Tartrate R-Isomer ((R)-3-[1-(Dimethylamino)ethyl]phenyl ethyl(methyl)carbamate, hydrogen tartrate)
Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereofFormula:C14H22N2O2·C4H6O6Color and Shape:White PowderMolecular weight:250.16813O-Desmethyl Gefitinib
CAS:Formula:C21H22ClFN4O3Color and Shape:Pale Yellow SolidMolecular weight:432.88Diamino Biotin
CAS:Applications Biotin (B389040) impurity. References Trotter, J., et al.: Biochemistry, 5, 713 (1966), Suurkuusk, J., et al.: Eur. J.Biochem., 28, 438 (1972),Formula:C9H18N2O2SColor and Shape:NeatMolecular weight:218.32(S)-(+)-Modafinil-d5
Formula:C15H10NO2SD5Color and Shape:White To Off-White SolidMolecular weight:278.395-Methylcytidine
CAS:Formula:C10H15N3O5Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:257.25(S)-(+)-2-Hydroxy-4-phthalimidobutyric Acid
CAS:Formula:C12H11NO5Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:249.22Deacetyl Ketoconazole
CAS:Controlled ProductImpurity Ketoconazole EP Impurity D Applications Deacetyl Ketoconazole (Ketoconazole EP Impurity D) is a Ketoconazole derivative. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageFormula:C24H26Cl2N4O3Color and Shape:Off-WhiteMolecular weight:489.395,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-
CAS:Formula:BH4O3PbPurity:98%Color and Shape:SolidMolecular weight:270.041Isoamyl Acetate-d4
CAS:Controlled ProductFormula:C7H10D4O2Color and Shape:NeatMolecular weight:134.21Posaconazole Diastereoisomer Related Compound 1
CAS:Formula:C21H21F2N3O4SColor and Shape:White To Off-White SolidMolecular weight:449.48Etoposide
CAS:Formula:C29H32O13Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:588.563-Amino-D-Alanine Hydrochloride
CAS:Formula:C3H9ClN2O2Purity:95%Color and Shape:SolidMolecular weight:140.5688Isopropyl Ethanesulfonate
CAS:Formula:C5H12O3SColor and Shape:Pale Yellow LiquidMolecular weight:152.21N-Desmethyl Loperamide-d3
CAS:Controlled ProductApplications A labelled metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Rahman, A., et al.: Cancer Res., 54, 5543 (1994), Sai, Y., et al.: Xenobiotica, 30, 327 (2000), Eneroth, A., et al.: Eur. J. Pharm. Sci., 12, 205 (2001), Kim, K., et al.: Drug Metab. Dispos., 31, 1090 (2003),Formula:C28H28D3ClN2O2Color and Shape:NeatMolecular weight:466.03Polymyxin B sulfate
CAS:Controlled ProductFormula:C55H96N16O13· 2H2SO4Color and Shape:NeatMolecular weight:1385.61Diphenhydramine N-Oxide
CAS:Formula:C17H21NO2Color and Shape:Pale Yellow SolidMolecular weight:271.36Levodropropizine (S-Dropropizine)
CAS:Formula:C13H20N2O2Color and Shape:White To Off-White SolidMolecular weight:236.32N2-Nitroso Folinate (N2-Nitroso Folic Acid USP Related Compound A, N2-Nitroso Leucovorin)
Formula:C20H22N8O8Molecular weight:502.44Ref: 4Z-C-466004
Discontinued product1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, hydrochloride (1:1)
CAS:Formula:C19H34ClNO2Purity:98%Color and Shape:SolidMolecular weight:343.9317599999998Efavirenz USP Related Compound B
CAS:Formula:C14H11ClF3NO2Color and Shape:White To Off-White SolidMolecular weight:317.697-[(Hydroxy-2-thienyl-3-thienylacetyl)oxy]-9,9-dimethyl-3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bro
CAS:Controlled ProductApplications 7-[(Hydroxy-2-thienyl-3-thienylacetyl)oxy]-9,9-dimethyl-3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide is an impurity in the synthesis of Tiotropium Bromide (T444850), a muscarinic receptor antagonist. Bronchodilator. References Rodgers, T. et al.: J. Med. Chem., 20, 591 (1977); Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994); Donohue, J. F., et al.: Chest, 122, 47 (2002); Profita, M., et al.: Allergy, 60, 1361 (2005); Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006);Formula:C19H22BrNO4S2Color and Shape:NeatMolecular weight:472.42Chlorcyclizine
CAS:Formula:C18H21ClN2Purity:>98.0%(GC)Color and Shape:Colorless to Light yellow clear liquidMolecular weight:300.83Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate
CAS:Controlled ProductApplications Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate Is an intermediate in the synthesis of novel series of HMG-CoA reductase inhibitors. References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997);Formula:C18H22FN3O4SColor and Shape:NeatMolecular weight:395.45Otilonium Bromide Impurity 3
CAS:Formula:C14H23N2O2·BrColor and Shape:White To Off-White SolidMolecular weight:251.35 79.90Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester,monohydrochloride
CAS:Formula:C16H27ClN2O3Purity:%Color and Shape:SolidMolecular weight:330.8502Sevoflurane Related Compound A (1,1,1,3,3-Pentafluoroisopropenyl fluoromethyl ether)
CAS:Ethers of monohydric alcohols, nesoiFormula:C4H2F6OColor and Shape:Colorless Clear LiquidMolecular weight:180.00098Ropinirole Related Compound B (4-[2-(Dipropylamino)ethyl]indoline-2,3-dione hydrochloride)
CAS:Lactams not elsewhere specified or includedFormula:C16H22N2O2·HClColor and Shape:Red Brown PowderMolecular weight:274.168132-Hydroxy-17Beta-estradiol
CAS:Applications A metabolite of Estradiol. References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),Formula:C18H24O3Color and Shape:Light Yellow To Dark YellowMolecular weight:288.38N-Phthaloylglycine
CAS:Formula:C10H7NO4Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:205.17Fosamprenavir Related Compound A (Calcium (6R,7S,16S,17R)-4,19-bis[(4-aminophenyl)sulfonyl]-7,16-dibenzyl-2,21-dimethyl-9,14-dioxo-10,13-dioxa-4,8,15,19-tetraazadocosane-6,17-diyl bis(phosphate))
Other aromatic organo-sulfur compounds (excluding pesticides)Formula:C44H58CaxN6O16P2S2Color and Shape:White Off-White PowderMolecular weight:1132.207784-Hydroxybenzophenone-d4
CAS:Controlled ProductApplications 4-Hydroxybenzophenone-d4 is an isotopic analog of 4-Hydroxybenzophenone (H829305), a metabolite of benzophenone (B204980). References Stocklinski, A. et al. Life Sciences 26, 365(1980)Formula:C13H6D4O2Color and Shape:NeatMolecular weight:202.245-Descyano Milrinone 5-Carboxyamide
CAS:Impurity Milrinone USP Related Compound A Stability Hygroscopic Applications 5-Descyano Milrinone 5-Carboxyamide (Milrinone USP Related Compound A) is an impurity of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic. References Alousi, A.A., et al.: J. Cardiovasc Pharmacol., 5, 792 (1983), Maskin, C.S., et al.: Circulation, 67, 1065 (1983), Sinoway, L.S., et al.: J. Am. Coll. Cardiol., 2, 327 (1983), Baim, D.S., et al.: N. Engl. J. Med., 309, 748 (1983),Formula:C12H11N3O2Color and Shape:Light YellowMolecular weight:229.232-Ethylhexanoic Acid
CAS:Applications 2-Ethylhexanoic Acid is used in biological studies as flavor precursor extraction from different grape varieties and its effect on wine aroma during alcohol fermentation References Loscos, N., et al.: J. Agric. Food Chem., 55, 6674 (2007)Formula:C8H16O2Color and Shape:NeatMolecular weight:144.21Dehydro Amlodipine Besylate
CAS:Controlled ProductApplications Dehydro Amlodipine Besylate is an impurity of Amlodipine (A633495), a dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer. References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987); Haria, M., et al.: Drugs, 50, 560 (1995)Formula:C2023ClN2O5·C6H6O3SColor and Shape:NeatMolecular weight:565.04Methyl alpha-Hydroxy-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate
CAS:Formula:C18H18N2O3Methyl 2-Amino-2-methylpropanoate Hydrochloride
CAS:Formula:C5H11NO2·HClPurity:>98.0%(T)Color and Shape:White to Light yellow powder to crystalMolecular weight:153.611-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-,O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate (1:1)
CAS:Formula:C19H25F3N2O6Purity:98%Color and Shape:SolidMolecular weight:434.4068(R)-3-Aminobutyric Acid
CAS:Formula:C4H9NO2Purity:>98.0%(T)Color and Shape:White to Almost white powder to crystalMolecular weight:103.12Allantoic Acid
CAS:Controlled ProductApplications A metabolic intermediate in nucleic acid metabolism. References Yoon, K., et al.: Nat. Prod. Sci., 14, 254 (2008), Ramazzina, I., et al.: J. Biol. Chem., 283, 23295 (2008), Kim, K., et al.: J. Mol. Biol., 387, 1067 (2009),Formula:C4H8N4O4Color and Shape:White To Off-WhiteMolecular weight:176.13Methyl N-(benzyloxycarbonyl)-2-(dimethylphosphono)glycinate
CAS:Formula:C13H18NO7PPurity:97%Color and Shape:SolidMolecular weight:331.2583ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate monohydrochloride
CAS:Formula:C17H21ClN2O2SPurity:98%Color and Shape:SolidMolecular weight:352.878839999999972'-Deoxy-4-thiouridine
CAS:Formula:C9H12N2O4SPurity:>95.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:244.27
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