Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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1-(3-Hydroxyphenyl)-2-(methylamino)ethanone Hydrochloride (Phenylephrone Hydrochloride)
CAS:Formula:C9H11NO2·ClHRivaroxaban Open Ring Methylamine ((S)-4-(4-((2-hydroxy-3-(methylamino)propyl)amino)phenyl)morpholin-3-one)
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C14H21N3O3Color and Shape:White Off-White SolidMolecular weight:279.15829Narcissoside
CAS:Applications Narcissoside is a flavonoid from Nitraria tangutorum. Narcissoside may have antiproliferative activity in human colon cancer cell line (HT29). References Wu, Z., et. al.: Chem. Nat. Compnd., 49, 1125 (2014); Serra, A.T., et. al.: Food Res. Int., 54, 892 (2013)Formula:C28H32O16Color and Shape:NeatMolecular weight:624.54Rasagiline Mesylate
CAS:Formula:C12H13N·CH4O3SColor and Shape:White To Off-White SolidMolecular weight:171.24 96.103,3-Bis(bromomethyl)oxetane
CAS:Formula:C5H8Br2OPurity:>95.0%(GC)Color and Shape:White or Colorless to Almost white or Almost colorless powder to lump to clear liquidMolecular weight:243.931-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid
CAS:Formula:C15H10Cl2N2O2Purity:99%Color and Shape:SolidMolecular weight:321.1581rac-Cinacalcet-d3 HCl
CAS:Formula:C22H19D3F3N·HClColor and Shape:White To Off-White SolidMolecular weight:360.44 36.46Levothyroxine Related Compound 4
CAS:Formula:C14H9I4NO3Color and Shape:White To Off-White SolidMolecular weight:746.85Ref: 4Z-T-286
Discontinued productMaslinic Acid
CAS:Formula:C30H48O4Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:472.713-[(Hydroxymethylphosphinyl)oxy] Propanoic Acid Disodium Salt
CAS:Formula:C4H7O5P·2NaMolecular weight:166.07 2*22.9913-Ethyl-3-ethynyl-18,19-dinor-17Alpha-pregna-3,5-dien-20-yn-17-ol(Levo Norgestrel Impurity)
CAS:Controlled ProductImpurity Levonorgestrel EP Impurity C Applications 13-Ethyl-3-ethynyl-18,19-dinor-17α-pregna-3,5-dien-20-yn-17-ol (Levonorgestrel EP Impurity C) is an impurity of Levonorgestrel.Formula:C23H28OColor and Shape:NeatMolecular weight:320.47Vitamin B1 O-Succinic Acid-N-Hydroxy Succinimide Tetrafluoroborate
Controlled ProductFormula:C20H24N5O6S·BF4Color and Shape:NeatMolecular weight:549.30Acetone 2,4-Dinitrophenylhydrazone-13C3
CAS:Controlled ProductApplications Isotope labelled Acetone 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic ketone found in mainstream cigarette smoke. Acetone 2,4-Dinitrophenylhydrazone showed inhibitory activity towards soybean lipoxygenase and renal prostaglandin synthetase. References Delgado, B. et al.: J. Liq. Chrom. Rel Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010); Baumann, J. et al.: Agents Act., 12, 360 (1982);Formula:C613C3H10N4O4Color and Shape:NeatMolecular weight:241.182-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-
CAS:Formula:C13H13N3O2Purity:97%Color and Shape:SolidMolecular weight:243.261222-Amino-3-methylbenzoic Acid
CAS:Formula:C8H9NO2Purity:>98.0%(T)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:151.17(R)-α-(2,2-dimethylpropyl)-1-methyl-1H-pyrrole-3-methanamine
CAS:Formula:C11H20N2Color and Shape:White To Off-White SolidMolecular weight:180.304-Sulfate Aminoantipyrine
CAS:Formula:C11H13N3O4SColor and Shape:Pale Yellow SolidMolecular weight:283.30Fluorofenidone Impurity 1-d3
CAS:Formula:C12H7D3FNO2Color and Shape:Pale Yellow SolidMolecular weight:222.23rel-(2R,3aR,5S,6S,6aS)-4-Methylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-6-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate
CAS:Controlled ProductFormula:C18H19NO4S2Color and Shape:NeatMolecular weight:377.4811-Azido-3,6,9-trioxaundecanol
CAS:Formula:C8H17N3O4Purity:>97.0%(GC)Color and Shape:Colorless to Yellow clear liquidMolecular weight:219.24tert-Butyl (3R,4S)-2-Oxo-4-phenyl-3-[(triethylsilyl)oxy]azetidine-1-carboxylate
CAS:Formula:C20H31NO4SiPurity:>97.0%(HPLC)Color and Shape:Colorless to Light yellow clear liquidMolecular weight:377.56Tioconazole Related Compound B (1-[2,4-Dichloro-β-[(2,5-dichloro-3-thenyl)oxy]phenethyl]imidazole hydrochloride)
Aromatic amino-alcohol-phenols, aromatic amino-acid-phenols and other aromatic amino compounds with oxygen functionFormula:C16H14Cl4N2OS·HClColor and Shape:PowderMolecular weight:421.95809Medetomidine HCl
CAS:Formula:C13H16N2·HClColor and Shape:White To Off-White SolidMolecular weight:200.29 36.46N-Nitroso Silodosin
CAS:Formula:C25H31F3N4O5Color and Shape:White To Off-White SolidMolecular weight:524.548-Hydroxytetradecanoic Acid
CAS:Controlled ProductFormula:C14H28O3Color and Shape:NeatMolecular weight:244.37(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid
CAS:Impurity Fluocinolone Acetonide EP Impurity B Applications (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching. References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),Formula:C23H28F2O6Color and Shape:Off-WhiteMolecular weight:438.46Econazole Related Compound C (1-(4-Chlorobenzyl)-3-[(2RS)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]imidazolium chloride)
CAS:Compounds containing an unfused imidazole ring, whether or not hydrogenated, in the structure, nesoiFormula:C25H21Cl5N2OColor and Shape:White PowderMolecular weight:540.00965N-(tert-Butoxycarbonyl)-4-phenyl-L-phenylalanine
CAS:Formula:C20H23NO4Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:341.41Methyl Diethyldithiocarbamate
CAS:Controlled ProductApplications A metabolite of a mixed disulfide S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine (AC-DDTC), an antimutagenic mixed disulfide from disulfiram. References Madan, A., et al.: Drug Metab. Dispos., 23, 1153 (1995), Lambert, D., et al.: J. Med. Chem., 48, 5059 (2005), Tsuboi, K., et al.: J. Biol. Chem., 280, 11082 (2005),Formula:C6H13NS2Color and Shape:NeatMolecular weight:163.302-(Dimethylamino)ethyl (p-chlorophenoxy)acetate hydrochloride
CAS:Formula:C12H17Cl2NO3Purity:98%Color and Shape:SolidMolecular weight:294.1743Tazemetostat-d8 (EPZ6438-d8)
CAS:Formula:C34H36D8N4O4Color and Shape:White To Off-White SolidMolecular weight:580.80D-2-Cyclohexylglycine
CAS:Formula:C8H15NO2Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:157.212,4,5-Trimethylaniline Hydrochloride
CAS:Controlled ProductStability Hygroscopic Applications 2,4,5-Trimethylaniline (T797580(P)) is the free base of 2,4,5-Trimethylaniline Hydrochloride. 2,4,5-Trimethylaniline is a carcinogenic aromatic amine used in the leather and textile industry. References Kawakami, Tsuyoshi, et al.: Kankyo Kagaku, 22(4), 197-204 (2012); Chen, Xiaomei, et al.: Fenxi Ceshi Xuebao, 17(4), 50-53 (1998);Formula:C9H13N·ClHColor and Shape:Light BrownMolecular weight:171.67p-Nicorandil
CAS:Applications A positional isomeric impurity of the antianginal Nicorandil (N398500). References Fedorov, B.S. et al.: Pharmac. Chem. J., 43, 134 (2009); Tatyanenko, L.V. et al.: Biomed. Khim., 52, 174 (2006);Formula:C8H9N3O4Color and Shape:BeigeMolecular weight:211.17Cevimeline Sulfoxide 1
CAS:Formula:C10H17NO2SColor and Shape:White To Off-White SolidMolecular weight:215.31Mycophenolic Acid-d3
CAS:Formula:C17H17D3O6Color and Shape:White To Off-White SolidMolecular weight:323.363,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontan-1-amine, 35-azido-
CAS:Formula:C24H50N4O11Purity:95%Color and Shape:LiquidMolecular weight:570.673999999999917-(Allylamino-d5) Geldanamycin
CAS:Controlled ProductApplications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),Formula:C31D5H38N3O8Color and Shape:NeatMolecular weight:590.719alfa-(E)-Brivudine
CAS:Formula:C11H13BrN2O5Color and Shape:White To Off-White SolidMolecular weight:333.14Cyproterone Acetate-d3
CAS:Formula:C24H26D3ClO4Color and Shape:White To Off-White SolidMolecular weight:419.963,6-Dichloro-1,2,4,5-tetrazine
CAS:Formula:C2Cl2N4Purity:>97.0%(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:150.95Eprosartan Related Compound E (4-(hydroxymethyl)benzoic acid) (DISCONTINUED)
CAS:Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc not elsewhere specified or includedFormula:C8H8O3Color and Shape:Beige White PowderMolecular weight:152.04734Methyl 3-[[(2RS)-2-Bromopropanoyl]amino]-4-methylthiophene-2-carboxylate (Bromo Compound)
CAS:Formula:C10H12BrNO3SNystose Trihydrate
CAS:Applications A hydrated form of Fungitetraose (F862808) which is part of the sugar mixture of Neosugar, sweetner. References Oku, T., et al.: J. Nutr., 114, 1574 (1984).Formula:C24H42O21·3(H2O)Color and Shape:White To Off-WhiteMolecular weight:720.64Hydroxy Itraconazole-d8
CAS:Controlled ProductApplications An isotopically Labelled metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product. References Saag, M., et al.: Antimicrob. Agents Chemother., 32, 1 (1988), Haria, M., et al.: Drugs, 51, 585 (1996), Kousoulos, C., et al.: Anal. Bioanal. Chem., 384,199 (2006),Formula:C35D8H30Cl2N8O5Color and Shape:NeatMolecular weight:729.68Dopamine Related Compound B (4-(2-Aminoethyl)-2-methoxyphenol hydrochloride)
CAS:Amino-naphthols and other amino-phenols, their ethers and esters, other than those cont more than one kind of oxygen function; salts thereof nesoiFormula:C9H13NO2·HClColor and Shape:Off-White SolidMolecular weight:203.07131Lactulose
CAS:Formula:C12H22O11Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:342.30Al (III) Phthalocyanine Chloride Tetrasulfonic Acid
CAS:Formula:C32H16AlClN8O12S4Molecular weight:893.927Antibiotic A 40926 (Mixture)
CAS:Controlled ProductApplications Antibiotic A 40926 is a Dalbavancin Impurity.Formula:C88H101Cl3N10O28Color and Shape:NeatMolecular weight:1853.1Carbinoxamine-d6 Maleate
CAS:Formula:C16H13D6ClN2O·C4H4O4Color and Shape:Off-White SolidMolecular weight:296.83 116.079,10-Secocholesta-5,7,10(19)-triene-3β,25-diol
CAS:Formula:C27H44O2Purity:90%Color and Shape:SolidMolecular weight:400.6371Betamethasone Dipropionate
CAS:Formula:C28H37FO7Color and Shape:White To Off-White SolidMolecular weight:504.60N-Methyl Etodolac
CAS:Controlled ProductApplications N-Methyl Etodolac is used in the preparation of indole derivatives as COX-1-, COX-2-, and β-catenin-inhibitors for treatment of multiple myeloma.Formula:C18H23NO3Color and Shape:NeatMolecular weight:301.383'-O-[tert-Butyl(dimethyl)silyl]thymidine
CAS:Formula:C16H28N2O5SiPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:356.496-Hydroxy-L-DOPA
CAS:Controlled ProductImpurity Levodopa EP Impurity A; Levodopa USP Related Compound A Stability Hygroscopic Applications 6-Hydroxy-L-DOPA (Levodopa EP Impurity A; Levodopa USP Related Compound A) is the 6-hydroxy derivative of the amino acid L-DOPA (D533751) with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase. References Jaim-Etcheverry, G. et al.: Brain Res., 100, 699 (1975); Kostrzewa, R.M. et al.: Amino Acids, 14, 175 (1998); Berthet, A. et al.: J. Neurosci., 29, 4829 (2009);Formula:C9H11NO5Color and Shape:Brown To BlackMolecular weight:213.19Serine, O-(phenylmethyl)
CAS:Formula:C10H13NO3Purity:98%Color and Shape:SolidMolecular weight:195.2151Palbociclib N-Beta-D-Glucuronide Sodium Salt (Technical Grade, ~65%)
CAS:Controlled ProductApplications Palbociclib N-β-D-Glucuronide is a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)Formula:C30H36N7NaO8Purity:~65%Color and Shape:NeatMolecular weight:645.64Lubiprostone-d7 (Mixture of Tautomeric Isomers)
CAS:Formula:C20H25D7F2O5Color and Shape:White To Off-White SolidMolecular weight:397.51
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