Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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L-Methionine Methyl Ester Hydrochloride
CAS:Formula:C6H13NO2S·HClPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:199.69Alogliptin Related Compound 16
CAS:Formula:C18H22N4O4Color and Shape:Off-White SolidMolecular weight:358.40Bis(2,4-dimethylphenyl) Disulfide
CAS:Controlled ProductApplications Bis(2,4-dimethylphenyl) Disulfide is an impurity of Vortioxetine Hydrobromide (V766000), a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3). Bis(2,4-dimethylphenyl) Disulfide used as a reactant in the preparation of vortioxetine salts using a new synthetic path. References Paunovic, A. et al.: ACS Chem. Biol., 12, 132 (2017); Haferkamp, S., et al.: Brit. UK Pat. Appl. 49 pp. (2018)Formula:C16H18S2Color and Shape:NeatMolecular weight:274.44Sulfo-N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate, Sodium Salt
CAS:Formula:C16H18N2NaO9SPurity:98%Color and Shape:SolidMolecular weight:437.3769[9(2R,5S,6R)]- 9-O-[5-(Dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]-3-O-methyl-17-methylene-leucomycin V
CAS:Controlled ProductApplications [9(2R,5S,6R)]- 9-O-[5-(Dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]-3-O-methyl-17-methylene-Leucomycin V is an impurity of Spiramycin (S682373). Spiramycin is a macrolide antibiotics. References Patil, S., et al.: World J. Pharm. Res., 5, 1529 (2016);Formula:C44H74N2O14Color and Shape:NeatMolecular weight:855.06Adenine 9-β-D-arabinofuranoside
CAS:Formula:C10H13N5O4Purity:95%Color and Shape:SolidMolecular weight:267.2413Tasimelteon-d5
CAS:Formula:C15H14D5NO2Color and Shape:White To Off-White SolidMolecular weight:250.35Pioglitazone N-Oxide
CAS:Formula:C19H20N2O4SColor and Shape:White To Off-White SolidMolecular weight:372.44Halquinol, mixture of 5,7-Dichloro-8-quinolinol, 5-Chloro-8-quinolinol, 7-Chloro-8-quinolinol and 8-Hydroxyquinoline
CAS:Applications Halquinol is an antimicrobial compound belonging to the group of hydroxyl-quinolines indicated for use in poultry and swine. It depresses the activity of the gastro-intestinal tract, causing longer transit time of feed through the intestine, thereby enhancing digestion and absorption of nutrients. It increases weight gain and improve feed conversionprevent and control nonspecific diarrhea or wet dropping in farming animals. References Costa, M. et al.: PLoS One, Vol. 12, (2017);Formula:C9H7NOC9H6ClNO·C9H5Cl2NOColor and Shape:BrownMolecular weight:393.65Norelgestromin Related Compound A (13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-5(6)-en-20-yn-3-one oxime)
Estrogens and progestinsFormula:C21H29NO2Color and Shape:SolidMolecular weight:327.21983Aminolevulinic Acid Hydrochloride USP Related Compound A
CAS:Formula:C10H12N2O4Molecular weight:224.22Pipazetate HCl (Pipazethate HCl)
CAS:Formula:C21H25N3O3S·HClColor and Shape:Off-White SolidMolecular weight:399.51 36.46Nε-(tert-Butoxycarbonyl)-Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-lysine
CAS:Formula:C26H32N2O6Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:468.55Verteporfin Related Compound A ((+/-)18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]prophine-9,13-dipropanoic acid)
CAS:Aromatic or modified aromatic drugs with nitrogen heterFormula:C40H40N4O8Color and Shape:Dark Green PowderMolecular weight:704.77Paliperidone E-oxime
CAS:Controlled ProductApplications Paliperidone E-oxime is an impurity of Paliperidone (P141000), a known orally active antipsychotic agent. References Rao, J., et al.: Pharmacia Lettre, 3, 240 (2011);Formula:C23H28F2N4O3Color and Shape:NeatMolecular weight:446.49Darunavir Ethanolate
CAS:Formula:C27H37N3O7S·C2H6OColor and Shape:White To Off-White SolidMolecular weight:547.67 46.07L-Ornithine-2,3,3,4,4,5,5-d7 hydrochloride
CAS:Controlled ProductApplications L-Ornithine-2,3,3,4,4,5,5-d7 hydrochloride is the labelled analogue of L-Ornithine Hydrochloride (O695550), a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta. References Fattori, D., et al.: J. Med. Chem., 50, 550 (2007), Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007), Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008),Formula:C5D7H5N2O2·ClHColor and Shape:NeatMolecular weight:175.1104926088Lorcaserin L-Tartrate
CAS:Formula:C11H14ClN·C4H6O6Color and Shape:White To Off-White SolidMolecular weight:195.69 150.09Hexyl Biguanide HCl
CAS:Formula:C8H19N5·HClColor and Shape:White To Off-White SolidMolecular weight:185.28 36.46Rebaudioside A
CAS:Formula:C44H70O23Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:967.02Betaxolol Hydrochloride
CAS:Formula:C18H30ClNO3Purity:98%Color and Shape:SolidMolecular weight:343.8887(R)-2-((4-Aminophenethyl)amino)-1-phenylethanol
CAS:Controlled ProductFormula:C16H20N2OColor and Shape:NeatMolecular weight:256.34Hydroxymethyl Celecoxib
CAS:Formula:C17H14F3N3O3SColor and Shape:White To Off-White SolidMolecular weight:397.37Glycine, N-(aminoiminomethyl)-N-methyl-, hydrate
CAS:Formula:C4H11N3O3Purity:97%Color and Shape:SolidMolecular weight:149.14843999999997Picaridin Related Compound 3 (Butan-2-yl Carbonochloridate)
CAS:Formula:C5H9ClO2Molecular weight:136.58Luliconazole
CAS:Formula:C14H9Cl2N3S2Purity:>98.0%(HPLC)(N)Color and Shape:White to Orange to Green powder to crystalMolecular weight:354.27Valproic Acid Related Compound A (2-allylpent-4-enoic acid)
CAS:Unsaturated acyclic monocarboxylic acids, their anhydriFormula:C8H12O2Color and Shape:Clear LiquidMolecular weight:140.08373(Benzotriazol-1-Yloxy)Tris(Dimethylamino)Phosphonium Hexafluorophosphate
CAS:Formula:C12H22F6N6OP2Purity:98%Color and Shape:SolidMolecular weight:442.2806(4S)-1-(3-hydroxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-4,8-diol
Formula:C16H17NO3Molecular weight:271.326alpha-Bromo Beclomethasone Dipropionate
CAS:Controlled ProductImpurity Beclomethasone Dipropionate EP Impurity F Applications 6α-Bromo Beclomethasone Dipropionate (Beclomethasone Dipropionate EP Impurity F) is an impurity of Beclomethasone Dipropionate (B131030).Formula:C28H36BrClO7Color and Shape:White SolidMolecular weight:599.94N-Nitrosodimethylamine (5.0 mg/mL in Methanol)
CAS:Controlled ProductFormula:C2H6N2OColor and Shape:Colourless To Light PinkMolecular weight:74.08Cinacalcet Related Compound E
Aromatic alcohols and their halogenated, sulfonated, nitrated or nitrosated derivatives not elsewhere specified or includedFormula:C10H11F3OColor and Shape:Colorless Clear Light Yellow Light Brown LiquidMolecular weight:204.0762Sulconazole Related Compound A (1-[2-(4-Chlorobenzyl)sulfinyl-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate)
CAS:Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure nesoiFormula:C18H15Cl3N2OS·HNO3Color and Shape:PowderMolecular weight:474.99271α-Methyldopa Sesquihydrate
CAS:Formula:C20H32N2O11Purity:98%Color and Shape:SolidMolecular weight:476.47487999999987(Bromomethanetriyl)tribenzene
CAS:Formula:C19H15BrPurity:98%Color and Shape:SolidMolecular weight:323.2264Donepezil-N-Oxide
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFormula:C24H29NO4Color and Shape:PowderMolecular weight:395.20966N-(2-Hydroxyethyl)maleimide
CAS:Formula:C6H7NO3Purity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:141.13N-des(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl-N-Cbz-Raltegravir
CAS:Controlled ProductApplications An intermediate in the preparation of HIV-integrase inhibitorsFormula:C24H25FN4O5Color and Shape:NeatMolecular weight:468.48Digitoxin
CAS:Formula:C41H64O13Purity:>97.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:764.95Atorvastatin Acetonide t-Butyl Ester Side Chain (4S,6S)-Isomer
CAS:Formula:C14H23NO4Molecular weight:269.343-Hydroxynaphthalene-2,7-Disulfonic acid Disodium Salt
CAS:Formula:C10H8O7S2·2NaMolecular weight:304.29 2*22.993'-Dehydrolutein (~90%)
CAS:Stability Light Sensitive, Temperature Sensitive Applications 3'-Dehydrolutein, is a derivative of Lutein, which is a naturally occurring carotenoids, and a natural part of human diet. It has also some medicinal applications. It can lowers the risk of cataract development, and used as an antioxidant. References Sangiovanni J. P., et al.: Arch. Ophthalmol., 125 (9), 1225 (2007); Malinow, M. R., et al.: Invest. Ophthalmol. Vis. Sci., 19 (8), 857 (1980);Formula:C40H54O2Purity:~90%Color and Shape:NeatMolecular weight:566.86Decaethylene Glycol
CAS:Formula:C20H42O11Purity:>90.0%(GC)Color and Shape:White or Colorless to Almost white or Almost colorless powder to lump to clear liquidMolecular weight:458.55E,E-Farnesylacetone
CAS:Controlled ProductStability Light Sensitive Applications E,E-Farnesylacetone, is a natural organic compound which is present in many essential oils. It has been shown that, Farnesylacetone inhibits electron transport in isolated rat liver mitochondria. References Dupont, J. et al.: Biology of the Cell, 67(2), 141-146 (1989); Gaviria, M. et al.: Chem. & Biodiversity 8, 532 (2011)Formula:C18H30OColor and Shape:NeatMolecular weight:262.43Boc-Ala-OSu
CAS:Formula:C12H18N2O6Purity:>95.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:286.28Nicoboxil HCl
CAS:Formula:C12H17NO3·HClColor and Shape:White To Off-White SolidMolecular weight:223.27 36.46Diclofenac Ethyl Ester
CAS:Controlled ProductImpurity Aceclofenac EP Impurity C Applications A Diclofenac derivative as anti-inflammatory and analgesic agent. Aceclofenac EP Impurity C Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Dannhardt, G., et al.: Eur. J. Med. Chem., 36, 109 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001),Formula:C16H15Cl2NO2Color and Shape:White To Light BrownMolecular weight:324.20Methyl 2,4-Dihydroxy-6-methylbenzoate
CAS:Controlled ProductApplications Methyl 2,4-Dihydroxy-6-methylbenzoate is a useful synthetic intermediate in the synthesis of Grifolic Acid (G786500); a selective partial GPR120 agonist. Grifolic Acid induces ERK and [Ca2+]i responses in cells expressing GPR120, but has no effects on those expressing GPR40. References Hara, T. et al.: Naun. Schmied. Arch. Pharmacol., 380, 247 (2009); Sun. Q. et al.: Mol. Pharmacol., 78, 804 (2010)Formula:C9H10O4Color and Shape:NeatMolecular weight:182.17para-Hydroxy Atorvastatin-d5 Calcium Salt
CAS:Formula:C33H29D5FN2O6·5CaColor and Shape:White To Off-White SolidMolecular weight:578.67 0.5*40.085-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2-oxo-N,4-diphenyl-1-[2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
CAS:Controlled ProductApplications 5-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2-oxo-N,4-diphenyl-1-[2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide is a photodegradation product of Atorvastatin (A791750). References Cermola, F., et al.: Tetrahedron., 62, 7390 (2006);Formula:C33H33FN2O5Color and Shape:NeatMolecular weight:556.62Suprofen
CAS:Formula:C14H12O3SPurity:>98.0%(GC)Color and Shape:White to Light yellow powder to crystalMolecular weight:260.31Nimodipine
CAS:Formula:C21H26N2O7Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:418.453',5-Di-2-propen-1-yl[1,1'-biphenyl]-2,4'-diol
CAS:Formula:C18H18O2Purity:95%Color and Shape:SolidMolecular weight:266.3343Ecamsule Related Compound B (4-(Hydroxymethyl)benzoic acid)
CAS:Carboxylic acids w/ alcohol function but w/o other oxygen function and their derivatives, nesoiFormula:C8H8O3Color and Shape:White Beige PowderMolecular weight:152.04734(S,R,S)-AHPC Hydrochloride
CAS:Formula:C22H30N4O3S·xHClPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalN-Nitroso Metformin EP Impurity E Dinitrite (N-Nitroso Metformin USP Related Compound B Dinitrite)
Formula:C3H8N6O·2HNO2Molecular weight:144.14 2*47.01L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-3,4-difluoro-
CAS:Formula:C14H17F2NO4Purity:97%Color and Shape:SolidMolecular weight:301.28594-(2-Cyanoethyl)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile
CAS:Formula:C14H14N2Color and Shape:Yellow SolidMolecular weight:210.28Benzoic acid, 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, methyl ester
CAS:Formula:C16H16N4O3Purity:97%Color and Shape:SolidMolecular weight:312.3232N-Deshydroxyethyl Dasatinib
CAS:Controlled ProductFormula:C20H22ClN7OSColor and Shape:Off-WhiteMolecular weight:443.95
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