Sulfonamides and Derivatives
Sulphonamides are compounds that contain a sulphonamide functional group (-SO₂NH₂), where a sulphur atom is bonded to an amino group. They were among the first synthetic antibiotics used in medicine, inhibiting folic acid synthesis in bacteria, which gives them antimicrobial properties. They are mainly used to treat bacterial infections, although their use has declined due to antimicrobial resistance. In addition to their use as antibiotics, sulphonamides also have applications in the treatment of diseases such as malaria and inflammatory bowel diseases.
At CymitQuimica, we offer high-purity sulphonamides and their derivatives for research in microbiology and pharmaceutical development.
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3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide
CAS:3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide is an impurity in the synthesis of a drug. It is not active and has no known therapeutic value. 3-Oxo-1,2-benzisothiazole-2(3H)-acetic acid ethyl ester 1,1-dioxide is used as a reference standard for HPLC and has been shown to be metabolized by cytochrome P450 enzymes.Formula:C11H11NO5SPurity:Min. 95%Color and Shape:White to off-white solid.Molecular weight:269.27 g/molEtodolac Peak Identification Mixture
Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoiFormula:C17H21NO3C16H19NO3C16H19NO3C18H23NO3C18H23NO3C12H15NOC15H17NO3C18H23NO3C18H23NO3C27H32N2O3C16H21NOC18H23NO3Color and Shape:White Off-White PowderMolecular weight:3462.903914-Hydroxy-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
CAS:4-Hydroxy-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1dioxide is a drug product that is used as an analytical reference material. It is a white to pale yellow powder that is soluble in water and has a molecular weight of 343.4 g/mol. The compound has been used for the development of drugs with therapeutic potential against cancer, diabetes, and other diseases. The following are some of the impurities that may be found in 4-hydroxy-N-2-pyridinyl-2H--1,2--benzothiazine--3--carboxamide--1,1dioxide: CAS No.: 65897 - 46 - 3 Molecular weight: 343.4 g/mol Melting point: Boiling point: Density: 1.7 g/cmFormula:C14H11N3O4SPurity:Min. 95%Molecular weight:317.32 g/molN-(5-Chloro-1,3,4-thiadiazol-2-yl)acetamide
CAS:Controlled ProductFormula:C4H4ClN3OSColor and Shape:NeatMolecular weight:177.61Acetazolamide Impurity 2
CAS:Formula:C8H8N6O2S4Color and Shape:Off-White SolidMolecular weight:348.45Trimethoprim Impurity 2
CAS:Formula:C14H16N2O5Color and Shape:White To Off-White SolidMolecular weight:292.291-[4-(2-Methylpropyl)phenyl]ethanone
CAS:Controlled ProductFormula:C12H16OColor and Shape:NeatMolecular weight:176.25Indapamide-13C-d3
CAS:Formula:C1513CH13D3ClN3O3SColor and Shape:White To Off-White SolidMolecular weight:369.844-Nitro-2-phenoxyaniline
CAS:Controlled ProductFormula:C12H10N2O3Color and Shape:NeatMolecular weight:230.222-Aminopyrimidine
CAS:Applications 2-Aminopyrimidine is used in the synthesis of sulfonamides as isoform-selective inhibitors with efficacy in rodent pain models. References Focken, T. et al.: ACS Med. Chem., 7, 277 (2016); Reddy, M. et al.: Bioorg. Med. Chem., 24, 521 (2016);Formula:C4H5N3Color and Shape:NeatMolecular weight:95.10Mefenamic acid
CAS:Mefenamic acid (CN-35355) is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties.Formula:C15H15NO2Purity:99.32%Color and Shape:Crystals SolidMolecular weight:241.29Dorzolamide Impurity 20
CAS:Formula:C10H13NO3S2Color and Shape:White To Off-White SolidMolecular weight:259.34Piroxicam EP impurity F
CAS:Formula:C12H13NO5SColor and Shape:White To Off-White SolidMolecular weight:283.31Metamizole Sodium Salt (Dipyrone)
CAS:Formula:C13H16N3O4S·NaColor and Shape:White To Off-White SolidMolecular weight:310.35 22.99Paracetamol EP Impurity N
CAS:Formula:C16H16N2O3Color and Shape:Off-White SolidMolecular weight:284.32Etodolac EP Impurity B (8-Methyl Etodolac)
CAS:Formula:C16H19NO3Color and Shape:White To Off-White SolidMolecular weight:273.333-Nitro-4-phenoxy-5-sulfamoylbenzoic Acid
CAS:Controlled ProductFormula:C13H10N2O7SColor and Shape:NeatMolecular weight:338.294-(Acetylamino)-3-bromobenzenesulfonyl chloride
CAS:4-(Acetylamino)-3-bromobenzenesulfonyl chloride is a white crystalline powder that is soluble in water, ethanol and chloroform. It has an analytical standard purity of 99% or greater. This compound can be used for research and development purposes as well as for the synthesis of pharmaceuticals. The impurity profile of 4-(acetylamino)-3-bromobenzenesulfonyl chloride includes 3-acetylbenzenesulfonic acid, sodium acetate, ammonium chloride, sodium sulfite, potassium bromide, potassium iodide, potassium carbonate, and potassium citrate.Formula:C8H7BrClNO3SPurity:Min. 95%Molecular weight:312.57 g/mol(2RS)-2-Methyl-1-nitroso-2,3-dihydro-1H-indole
CAS:Controlled ProductFormula:C9H10N2OColor and Shape:NeatMolecular weight:162.192-[(1RS)-1-Ethyl-8-(1-methylethyl)-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic Acid (8-Isopropyl Etodolac)
CAS:Controlled ProductFormula:C18H23NO3Color and Shape:NeatMolecular weight:301.38(4R,6S)-Dorzolamide EP Impurity B
CAS:Formula:C10H16N2O4S3Color and Shape:White To Off-White SolidMolecular weight:324.43Glimepiride EP Impurity H (Glimepiride Toluene Analog)
Formula:C24H28N4O5SColor and Shape:White To Off-White SolidMolecular weight:484.57Methyl 2-disazobenzoate hydrochloride
CAS:Methyl 2-disazobenzoate hydrochloride is a drug product that is used as an HPLC standard and as a metabolite in the development of drugs. It has been found to be naturally occurring and is a research and development metabolite. Methyl 2-disazobenzoate hydrochloride is also an impurity of API, which can be quantified in analytical studies. It is a synthetic compound with CAS No. 35358-78-2 and it can be used to manufacture high purity pharmaceuticals. Methyl 2-disazobenzoate hydrochloride has been shown to have niche pharmacological effects, such as anti-inflammatory activities.Formula:C8H7N2O2ClPurity:Min. 95%Molecular weight:198.61 g/molEtodolac EP Impurity K
CAS:Formula:C18H23NO3Color and Shape:White To Off-White SolidMolecular weight:301.39(2-Isopropoxy-2-oxoethyl) 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetate
Formula:C17H21NO5Color and Shape:Neat5-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt
CAS:Controlled ProductStability Hygroscopic Applications 5-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt is an impurity of mesalamine (M258100), which is the active metabolite of Sulfasalazine (S699084). Anti-inflammatory (gastrointestinal). References Friedman, G., et al.: Am. J. Gastroenterol., 81, 141 (1986); Tursi A., Expert Opin. Pharmacother., 6, 69 (2005);Formula:C13H11NO6S•x(Na)Color and Shape:NeatMolecular weight:309.29 + x(22.99)Acetazolamide EP Impurity F
CAS:Formula:C8H9N7O6S4Color and Shape:White To Off-White SolidMolecular weight:427.44Metolazone EP Impurity A
CAS:Formula:C16H16ClN3O3SColor and Shape:White To Off-White SolidMolecular weight:365.834-(Diethylboranyl) pyridine
CAS:4-(Diethylboranyl)pyridine is a nucleophilic, anticoagulant drug. It interacts with the electronegative oxygen atoms in the guanine base of dna to form an adduct, which inhibits DNA synthesis. The hexameric cavity of 4-(Diethylboranyl)pyridine contains boron and nitrogen atoms, which are important for its activity. 4-(Diethylboranyl)pyridine also has antibacterial effects against gram-positive bacteria by inhibiting bacterial protein synthesis. This compound is synthetic and can be used in cocrystallized form as a single molecule or in hexameric form.Formula:C9H14BNPurity:Min. 95%Molecular weight:147.03 g/molGlimepiride EP Impurity G (Glimepiride N-Methyl Ester)
Formula:C19H25N3O6SColor and Shape:White To Off-White SolidMolecular weight:423.48(3S)-3-Hydroxy Quinine
CAS:Formula:C20H24N2O3Color and Shape:White To Off-White SolidMolecular weight:340.431-[[4-[2-[[(3-Ethyl-4-methyl-2-oxo-2,3-dihydro-1H-pyrrol-1-yl)carbonyl]amino]ethyl]phenyl]sulphonyl]-3-(cis-4-methylcyclohexyl)urea (cis-Glimepiride)
CAS:Controlled ProductFormula:C24H34N4O5SColor and Shape:NeatMolecular weight:490.621-(Piperidine-1-sulfonyl)piperazine
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:233.3300018310547Ibuprofen EP Impurity G (Mixture of cis and trans Isomers)
CAS:Formula:C26H32O4Color and Shape:White To Off-White SolidMolecular weight:408.54Sulfanilic Acid (4-Aminobenzenesulfonic acid)
CAS:Aniline derivatives and their saltsFormula:C6H7NO3SColor and Shape:Colorless Light Grey PowderMolecular weight:173.01466Glimepiride EP Impurity A (Glimepiride USP Related Compound A)
CAS:Formula:C24H34N4O5SColor and Shape:White To Off-White SolidMolecular weight:490.63Glimepiride-d4
CAS:Formula:C24H30D4N4O5SColor and Shape:White To Off-White SolidMolecular weight:494.64Ibuprofen Ethyl Ester
CAS:Formula:C15H22O2Color and Shape:White To Off-White SolidMolecular weight:234.34Dimethyl n-methylsulfamide
CAS:Purity:97.0%Color and Shape:Liquid, ClearMolecular weight:138.19000244140625Dorzolamide Impurity 5
CAS:Formula:C10H14N2O5S3Color and Shape:White To Off-White SolidMolecular weight:338.41Dorzolamide Impurity 3
CAS:Formula:C10H14N2O5S3Color and Shape:White To Off-White SolidMolecular weight:338.41Dorzolamide Impurity 1
CAS:Formula:C12H18N2O5S3Color and Shape:Pale Brown SolidMolecular weight:366.47Glipizide EP Impurity F
CAS:Controlled ProductFormula:C11H16N2O4SColor and Shape:NeatMolecular weight:272.324-Carboxy Tolbutamide
CAS:Formula:C12H16N2O5SColor and Shape:White To Off-White SolidMolecular weight:300.33(1RS,4RS)-7-(2-Methylpropyl)-1-[4-(2-methylpropyl)phenyl]-1,2,3,4-tetrahydronaphthalene-1,4-dicarboxylic Acid
CAS:Controlled ProductFormula:C26H32O4Color and Shape:NeatMolecular weight:408.53Metamizole Magnesium Salt
CAS:Formula:C26H32N6O8S2·MgColor and Shape:White To Off-White SolidMolecular weight:2*310.35 24.313-Ethyl-4-methyl-2-oxo-N-[2-(4-sulphamoylphenyl)ethyl]-2,3-dihydro-1H-pyrrole-1-carboxamide (Glimepiride Sulphonamide)
CAS:Controlled ProductFormula:C16H21N3O4SColor and Shape:NeatMolecular weight:351.42Metamizole EP Impurity E Sodium Salt
CAS:Formula:C12H14N3O4S·NaColor and Shape:White To Off-White SolidMolecular weight:296.32 22.99Ibuprofen Impurity 18 (4-Isobutylstyrene)
CAS:Formula:C12H16Color and Shape:Colorless Clear LiquidMolecular weight:160.26rac trans-4-Hydroxy Glyburide
CAS:Formula:C23H28ClN3O6SColor and Shape:White To Off-White SolidMolecular weight:510.012,4-Bis[(furan-2-ylmethyl)amino]-5-sulphamoylbenzoic Acid
CAS:Controlled ProductFormula:C17H17N3O6SColor and Shape:NeatMolecular weight:391.40Hydrochlorothiazide Dimer
CAS:Impurity Hydrochlorothiazide EP Impurity C Applications N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide (Hydrochlorothiazide EP Impurity C) is an impurity in bulk Hydrochlorothiazide. Dimer Impurity C. References Daniels, S.L., et al.: J. Pharm. Sci., 70, 211 (1981), Fang, X., et al.: Pharm. Res., 14, 691 (1997),Formula:C15H16Cl2N6O8S4Color and Shape:Off-WhiteMolecular weight:607.49Furosemide EP Impurity F
CAS:Formula:C12H15ClN2O5SColor and Shape:White To Off-White SolidMolecular weight:334.773-(Phenylamino)-2-(3,4,5-trimethoxybenzyl)prop-2-enenitrile (E/Z-mixture)
CAS:Controlled ProductFormula:C19H20N2O3Color and Shape:MixtureMolecular weight:324.37Niflumic Acid EP Impurity F
CAS:Controlled ProductFormula:C14H11F3N2O2Color and Shape:NeatMolecular weight:296.24Spiramycin Adipate
CAS:Controlled ProductFormula:C43H74N2O14C6H10O4Color and Shape:NeatMolecular weight:989.19Aceclofenac ethyl ester
CAS:Aceclofenac ethyl ester is a prodrug of diclofenac. It is a non-steroidal anti-inflammatory drug that alleviates the symptoms of pain, stiffness, and swelling. It exerts its effects by inhibiting prostaglandin synthesis in the central nervous system and peripheral tissues. Aceclofenac ethyl ester has minimal systemic absorption when administered orally, which reduces the risk of side effects such as stomach upset and kidney damage. The pharmacopoeia provides an efficient method for preparing this compound by reacting diclofenac with magnesium stearate in a solvent containing an organic amine or alcohol at temperatures below 50°C (122°F). Aceclofenac ethyl ester may contain impurities such as benzyl alcohol, polyvinylpyrrolidone, or magnesium stearate.Formula:C18H17Cl2NO4Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:382.24 g/mol2-(4-Isobutyrylphenyl)propane
CAS:Controlled ProductFormula:C13H18OColor and Shape:NeatMolecular weight:190.28Glipizide EP Impurity C
CAS:Formula:C18H27N3O5SColor and Shape:White To Off-White SolidMolecular weight:397.49Niflumic acid
CAS:Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.Formula:C13H9F3N2O2Purity:99.47%Color and Shape:SolidMolecular weight:282.22Ibuprofen Impurity 28
CAS:Formula:C10H10O4Color and Shape:White To Off-White SolidMolecular weight:194.19Sulfadiazine Sodium Salt
CAS:Formula:C10H9N4O2S·NaColor and Shape:White To Off-White SolidMolecular weight:249.27 22.99Glipizide EP Impurity H
CAS:Formula:C15H23N3O3SColor and Shape:White To Off-White SolidMolecular weight:325.43Rimsulfuron
CAS:Rimsulfuron, a postemergence sulfonylurea herbicide for maize, controls grasses and select broadleaf weeds.Formula:C14H17N5O7S2Color and Shape:SolidMolecular weight:431.44Brodimoprim
CAS:Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).Formula:C13H15BrN4O2Purity:98% - 98.33%Color and Shape:SolidMolecular weight:339.191,1-Bis(p-isobutylphenyl)ethane
CAS:1,1-Bis(p-isobutylphenyl)ethane is an acid catalyst that can be used in the synthesis of alkyl esters. It is unreactive at high temperatures and can be reused many times. 1,1-Bis(p-isobutylphenyl)ethane is also a component of catalytic carbonylation reactions. It reacts with acetaldehyde to form a metal carbonyl complex, which then reacts with a carbon monoxide molecule to form an ester. Carbonylation reactions are often used to synthesize organic compounds from alkyl halides or alcohols. Carbonylation reactions are catalyzed by metal carbonyls, such as palladium and nickel complexes.Formula:C22H30Purity:Min. 95%Molecular weight:294.47 g/mol2-[[4-(2-Pyridylsulfamoyl)phenyl]azo]hydroxybenzene
CAS:2-[[4-(2-Pyridylsulfamoyl)phenyl]azo]hydroxybenzene is an impurity found in sulfasalazine. It is a metabolite that is formed by the P450 system in the liver. The metabolic process of 2-[[4-(2-Pyridylsulfamoyl)phenyl]azo]hydroxybenzene has been studied in detail and has been shown to be a major contributor to the pharmacokinetic profile of sulfasalazine. This substance also exhibits antimicrobial activity and inhibits the growth of bacteria, fungi, and viruses.Formula:C17H14N4O3SPurity:Min. 95%Molecular weight:354.38 g/molIbuprofen EP Impurity E (Ibuprofen USP Related Compound C)
CAS:Formula:C12H16OColor and Shape:Pale Yellow LiquidMolecular weight:176.264-Amino-5,6-dimethoxypyrimidine
CAS:4-Amino-5,6-dimethoxypyrimidine is a pyrimethamine derivative that has been used as an antimalarial agent. It is a high yield compound with a chromatographic profile that can be used to identify impurities of other compounds. 4-Amino-5,6-dimethoxypyrimidine is eluted at the same time as sulfadoxine and can be used to calculate the concentration of sulfadoxine in a mixture. It can also be used as a reagent for rp-hplc. The linearity of this compound was tested by calibrating it against pyrimethamine and quantifying it using UV/Vis spectroscopy over the range 0.05 to 1 mg/mL.Formula:C6H9N3O2Purity:Min. 95%Molecular weight:155.15 g/molGliclazide
CAS:Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of theFormula:C15H21N3O3SPurity:99.58%Color and Shape:SolidMolecular weight:323.41Indomethacin Impurity 16
CAS:Formula:C10H11ClO4Color and Shape:White To Off-White SolidMolecular weight:230.64Indapamide Impurity 13 (4-Chloro-3-Sulfamoylbenzoyl Chloride)
CAS:Formula:C7H5Cl2NO3SColor and Shape:Off-White SolidMolecular weight:254.08Niflumic Acid EP Impurity B
CAS:Controlled ProductFormula:C13H9F3N2O2Color and Shape:NeatMolecular weight:282.22Paracetamol EP Impurity O
CAS:Formula:C16H16N2O4Color and Shape:Off-White SolidMolecular weight:300.314-[2-[(Cyclohexylcarbamoyl)amino]ethyl]benzenesulphonamide
CAS:Controlled ProductFormula:C15H23N3O3SColor and Shape:NeatMolecular weight:325.43Sulfacetamide sodium
CAS:Sulfacetamide sodium (Sulamyd sodium) is an anti-infective agent. It is used topically to treat orally for urinary tract infections and skin infections.Formula:C8H9N2NaO3SPurity:99.90% - 99.96%Color and Shape:White Crystalline PowderMolecular weight:236.222-Nitroso-octahydrocyclopenta[c]pyrrole
CAS:Controlled ProductFormula:C7H12N2OColor and Shape:NeatMolecular weight:140.18
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