Botanical Source

Gypenoside IX is a saponin compound, which is extracted from the Gynostemma pentaphyllum plant. This source is a perennial climbing herb known for its extensive use in traditional medicine throughout Asia. The mode of action of Gypenoside IX involves modulation of various signaling pathways, such as AMPK and PI3K/Akt, which play significant roles in cellular energy homeostasis and apoptotic processes. The applications and uses of Gypenoside IX are being rigorously studied in contemporary research settings. Scientists have investigated its potential anti-inflammatory, antioxidant, and anti-cancer properties. In addition to these, there is interest in its role in regulating lipid metabolism, which could have implications for treating metabolic disorders like diabetes and obesity. Given its diverse biochemical interactions, Gypenoside IX is a subject of interest for those looking at innovative approaches in pharmacology and therapeutic development.

Cucurbitacin A inhibits cancer growth in A-549 NSCLC cells by inducing apoptosis, targeting m-TOR/PI3K/Akt signalling pathway and G2/M cell cycle.

Isocucurbitacin B has significantly activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73uM.