Botanical Source

Isochlorogenic acid C possesses potent hepatoprotective and anti-HBV effects; the anti-apoptotic and anti-injury effects could be achieved by its anti-oxidative properties and interfering the caspase-3 and TGF-beta expressions.;the anti-HBV target may mainly be at the downstream links of HBV replication process and is probably associated with blocking translation step.

Schisandrin B, a kind of ATR and P-gp inhibitor with high safety, has been shown to produce antioxidant effect on rodent liver and heart. It also has anti-photoaging, and presents promising activities for future development of protective agents against CisPt nephrotoxicity. Combination of schizandrin B and paclitaxel(PTX) can enhance anti-tumor effects and relieve side effects of PTX on rats with mammary carcinoma.

Schisantherin A exhibits anti-tussive, sedative, anti-inflammatory, antioxidant, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. Schisantherin A can significantly attenuate Aβ1-42-induced learning and memory impairment and noticeably improve the histopathological changes in the hippocampus. Schisantherin A exhibits neuroprotection against 1-methyl-4-phenylpyridinium ion (MPP(+)) through the regulation of two distinct pathways including increasing CREB-mediated Bcl-2 expression and activating PI3K/Akt survival signaling.

Isochlorogenic acid A possesses the potent anti-hepatitis B activity and anti-HBV activity, could be achieved by its antioxidative property and induction of HO-1.

6-O-Acetylscandoside is a natural compound classified as an iridoid glycoside, sourced primarily from certain plant species known for their medicinal properties. The molecular structure of this compound includes an acetyl group attached to the 6-O position of scandoside, a modification that is significant in understanding its bioactivity. Iridoid glycosides like 6-O-Acetylscandoside are secondary metabolites in plants, often implicated in defense mechanisms against herbivores and pathogens. The mode of action of 6-O-Acetylscandoside involves modulation of biochemical pathways due to its glycosidic linkage and acetyl modification, potentially influencing enzyme interactions and receptor binding. This alteration can impact cellular processes and signal transduction, making it of interest in pharmacological studies. The applications of 6-O-Acetylscandoside are largely in the field of natural product research, where it is investigated for its potential therapeutic properties, such as anti-inflammatory and antimicrobial effects. Its role as a bioactive compound also extends to ecological studies, where understanding its function in plant defense can lead to insights on plant-environment interactions. Further research is crucial to elucidate its pharmacokinetics and potential clinical uses.

Forsythoside A possesses strong antibacterial, antiinflammatory, antioxidant and antiviral effects. it has the potential to prevent IBV infection in vitro, it can promote the expression of IFN-α and Mx1 significantly.Forsythoside A has inductive effects on the activities of CYP1A2 and CYP2C11, without affecting CYP2D1 and CYP3A1/2 activities.