Phthalate Standards

Applications Labelled Mono(3-hydroxybutyl)phthalate (M546300). Mono(3-hydroxybutyl)phthalate is a metabolite of Dibutyl phthalate (DBP) (D429495), which is widely used in consumer products. References Silva, M., et al.: Arch. Toxicol., 77, 561 (2003), Silva, M., et al.: Toxicology, 210, 123 (2005), Silva, M., et al.: J. Anal. Toxicol., 29, 819, (2005),

Applications An isotope labelled derivative of rac Mono(2-ethyl-5-oxohexyl) Phthalate (M542522), a phthalate metabolite. References Ye, X., et al.: Environ. Res., 108, 260 (2008), Engel, S., et al.: NeuroToxicol., 30, 522 (2009), Samandar, E., et al.: Environ. Res., 109, 641 (2009), Anderson, W., et al.: Food Chem. Toxicol., 49, 2022 (2011),

Applications Decyl Octyl Phthalate is an phthalate esters used as plasticizers and additives. Used in toxiciology studies as well as risk assessment studies of food contamination that occurs via migration of phthalates into foodstuffs from food-contact materials (FCM). References Bower, R.K., et al.: J. Pharmacol. Experiment. Therapeu., 171, 314 (1970); Smyth, H.F, et al.: Am. Indust. Hygiene. Assoc. J., 30, 470 (1969);

Applications Mono-(4-methyl-7-oxooctyl)pththalate is a metabolite of oxidized di-iso-nonylphthalates (DINP) molecules that are plasticizers used to improve the various physical characteristics. References Koch, H. et al.: J. Chrom. B. Anal. Tech. Biomed. Life Sci., 847, 114 (2007);

Applications Bis(2-Ethylbutyl) Phthalate, can be used in plastics manufacture and processing. References Pierson, J. F. et al.: Angewandte Makromolekulare Chemie, Vol. 38, P: 167-89 (1974);

Applications Labelled analogue of Mono(5-carboxy-2-ethylpentyl) Phthalate, a metabolite of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850). References Engel, S. et al.: NeuroToxicol., 30, 522 (2009); Hernandez-Diaz, S. et al.: Environ. Health Perspectives, 117, 185 (2009); Berman, T. et al.: Environ. Int., 35, 353 (2009);

Applications 1,2,4-Benzenetricarboxylic Acid 4-(2-ethylhexyl) Ester-d17 is labelled 1,2,4-Benzenetricarboxylic Acid 4-(2-ethylhexyl) Ester which is an analog of Trioctyl Trimellitate (T804400). Trioctyl Trimellitate (T804400) is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay. References Riddick, W.: J. Coating. Technol., 55, 57 (1983); Ito, R., et al.: Int. J. Pharma., 360, 91 (2008); Ohashi, A., et al.: J. Artific. Organs., 8, 252 (2005);

Applications Dibutyltin Dichloride-d18 is a labeled analogue of Dibutyltin Dichloride (D429550) (CAS# 683-18-1), which is an organotin compound that is widely used as a stabilizer for polyvinylchloride plastics. Studies show that exposure to Dibutyltin Dichloride induced acute interstitial pancreatitis in rats. Dibutyltin Dichloride showed in vitro trypanocidal activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Merkord, J. et al.: Hum. Exp. Toxicol., 17, 144 (1998); Shuaibu, M.N. et al.: Parasitol. Res., 91, 5 (2003); Whalen, M.M. et al.: Toxicol. Sci., 104, 312 (2008);

Applications Labelled Bis(2-ethylhexyl)phthalate. Bis(2-ethylhexyl) Phthalate plasticizer is used to impart softness and flexibility to PVC products. References Heindel, J., et al.: Toxicol. Appl. Pharmacol., 115, 116 (1992), Kasahara, E., et al.: Biochem. J., 365, 849 (2002), Lee, B., et al.: J. Toxicol. Environ. Health, 70, 1365 (2007),

Applications 2-(((4-Methyl-7-oxyooctyl)oxy)carbonyl)(cyclohexane-d8)carboxylic Acid is the labeled analogue of 2-(((4-Methyl-7-oxyooctyl)oxy)carbonyl)cyclohexanecarboxylic Acid (M329200), a secondary oxidized metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH) and may be used as biomarkers of DINCH exposure. DINCH is a major substitute for some high molecular weight phthalates that adversely affect reproductive function. References Schutze, A., et. al.: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 895, 123 (2012)

Applications The labelled analogue of a phthalate Ester metabolite, linked to precocious puberty. References Engel, S., et al.: NeuroToxicol., 30, 522 (2009), Blair, J., et al.: Environ., Sci., Technol., 43, 6262 (2009), Xu, Z., et al.: Environ. Sci. Technol., 44, 3130 (2010), Clewell, R., et al.: Toxicol. in Vitro, 24, 327 (2010),