APIs for research and impurities

Stability Light Sensitive Applications 3-Chloro-3’,5,5’-triiodo-L-thyronine is a chlorinated derivative of 3,3’,5’-Triiodo-L-thyronine (T795350), used for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus. References Block, P.: J. Med. Chem., 19(8), 1067-1069 (1976); Shiba, T., & Cahmann, H.J.: J.O.C., 29, 1652-1653 (1964)

Stability Light Sensitive, Temperature Sensitive Applications Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 9 is a form of vitamin K2 which acts as a prothrombogenic agent and is also a functional electron transfer component in nitrate reductase. References Hugenholtz, P., et al.: J. Bacteriol., 180, 4765 (1998), Ginet, N., et al.: Biochemistry, 40, 1812 (2001), Cape, J., et al.: J. Biol. Chem., 280, 34654 (2005),

Abacavir is an antiviral drug that is used to treat HIV/AIDS. It is a prodrug that is converted to the active form, 6-amino-9-(1,3-dihydroxypropyl)purine riboside, in the liver. Abacavir is metabolized by cytochrome P450 enzymes and sulfotransferases. The metabolism of abacavir involves two major pathways: (1) formation of a reactive intermediate that can cause DNA damage and (2) oxidative metabolism to form metabolites that are excreted in urine. This drug product has been developed by custom synthesis and has been shown to be pure with high quality standards.

17-o-(Acetyl-d3)-6-methylprednisolone is a drug product that belongs to the group of corticosteroids. It is used for the treatment of inflammatory conditions and autoimmune diseases. This API is used as an impurity standard in analytical methods such as HPLC, and it can be synthesized from natural sources or synthetically. 17-o-(Acetyl-d3)-6-methylprednisolone can also be used in R&D for the development of drugs targeting niche markets, such as those with high purity requirements.

Applications Calusterone-d5 is the labeled analogue of Calusterone (C148900), a synthetic androgen epimeric with Bolasterone (B674970). Has been used in treatment of breast cancer. Controlled substance (anabolic steroid). References Horn, H., et al.: Br. J. Cancer, 33, 336 (1976); Zumoff, B., et al.: J. Clin. Endocrinol. Metab., 44(6), 1203 (1977)