APIs for research and impurities

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Cetirizine glycerol ester impurity is a drug product that is an analytical impurity. It is a natural, API impurity, and synthetic. The CAS number for this impurity is 1243652-36-9. Research and Development (R&D) of cetirizine glycerol ester impurity is required for the manufacture of pharmaceutical products. High purity cetirizine glycerol ester impurity can be used as a pharmacopoeia standard for HPLC analyses.

Applications An N-alkylated Amphetamine (A634240) derivative. It shows the same toxicokinetic activity as amphetaminil, benzphetamine, clobenzorex, dimethylamphetamine, ethylamphetamine, famprofazone, fencamine, fenethylline, fenproporex, mefenorex, mesocarb, methamphetamine (M258785), prenylamine, and selegiline (D288641). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hiramatsu, M., et al.: J. Pharmacol. Exp. Ther., 254, 521 (1990), Lin, L., et al.: Drug Metab. Dispos., 25, 1059 (1997), Wu, D., et al.: Biochem. Pharmacol., 53, 1605 (1997),

Applications Tesofensine, is a serotonin-noradrenaline-dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity. References Hansen, H., et al.: Pharmacology, Biochemistry and Behavior, 110, 265 (2013);

Esmolol is a drug product that has been developed for the treatment of cardiac arrhythmias. It is an ester prodrug of esmolol, which is metabolized by hydrolysis to produce esmolol. Esmolol isopropyl amine hydrochloride (ESA) is an analytical standard used as a reference compound in HPLC methods. ESA is an impurity standard for API esmolol and CAS number 83356-59-6. Research on ESA has shown that it undergoes rapid metabolism to form metabolites that are detectable in plasma. Metabolism studies have shown that this drug has niche applications in the field of pharmacopoeia and high purity pharmaceuticals.

Applications Phensuximide is an anticonvulsant drug, used in the treatment of neurological disorders stemming from the brain. Antiepileptic. References Ferrendelli, J. et al.: Annals Neuro., 5, 533 (1979); Bruno-Blanch, L. et al.: Bioorg. Med. Chem. Lett., 13, 2749 (2003);

Applications Progestogen. In combination with estrogen as oral contraceptive. References Hahn, D.W., et al.: Contraception, 16, 541 (1977), Weintraub, H.S., et al.: J. Pharm. Sci., 67, 1406 (1978),

Ambroxol hydrochloride impurity C is a by-product of ambroxol hydrochloride. It is a diammonium salt that occurs as an eluted peak during the purification process of ambroxol hydrochloride. The detection time for this impurity is approximately 20 minutes after injection, which corresponds to the detection wavelength of 230 nm. Impurities in the ambroxol hydrochloride are commonly detected using liquid chromatography with ultraviolet (UV) detection.

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Pinoxaden is a protein kinase inhibitor that has shown promising results in the treatment of cancer. It specifically targets cyclin-dependent kinases, which are key regulators of cell division and proliferation. By inhibiting these kinases, Pinoxaden induces apoptosis (programmed cell death) in cancer cells, thereby preventing tumor growth and metastasis. This drug is an analog of a Chinese herbal medicine and has been shown to have potent anticancer activity both in vitro and in vivo. In addition, Pinoxaden has low toxicity and is excreted primarily through urine, making it a promising candidate for further development as an anticancer agent.