APIs for research and impurities

Applications Antitumor agent. References Morse, M., et al.: Cancer Res., 50, 2613 (1990), Staretz, M., et al.: Carcinogenesis, 18, 1715 (1997), Henderson, C., et al.: J. Biol. Chem., 278, 13480 (2003), Jalas, J., et al.: Chem. Res. Toxicol., 16, 794 (2003), Su, T., et al.: Toxicol. Appl. Pharmacol., 199, 285 (2004),

Pyrrolcarbonyltaloside is a drug product that is used as an HPLC standard for the analysis of impurities in API. It is also used as a synthetic intermediate in the synthesis of other chemical compounds. Pyrrolcarbonyltaloside has been shown to have anti-inflammatory and analgesic properties, and may be useful as a treatment for cancer.

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Stability Hygroscopic Applications Auristatin F is an antimitotic auristatin derivative that has been shown as a potent antitumor agent. References Doronina S.O., et al.: Bioconjugate Chem., 17, 114-124 (2006);

Soluble in Chloroform & in Methanol Confirmed Insoluble in Wate

Cefpodoxime proxetil impurity C is an impurity in cefpodoxime proxetil, a drug that belongs to the group of penicillins. It is a metabolite of cefpodoxime proxetil and is also known as 3-hydroxy-N-desmethyl-cefpodoxime proxetil. It has an analytical purity of 98% with a HPLC standard purity of 99%. This impurity can be synthesized from natural or synthetic materials. It has been shown to have pharmacopoeia, natural, and synthetic origins.

(RS)-Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)pyridine-3,5-dicarboxylate is a white to off-white crystalline powder that is soluble in methanol and slightly soluble in water. It can be used as an impurity standard for the API drug product, research and development and metabolism studies. The CAS number for this compound is 2200280-99-3. This compound has a purity of 99% or greater with an analytical purity of 99.9%. This compound has been shown to have a melting point of about 237°C and a density of 1.06 g/cm3. This compound is insoluble in ether and acetone.

Applications Xylazine is used as a sedative, analgesic, muscle relaxant. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Pernikoff, M., et al.: Clin. Med., 71, 699 (1964), Burns, M., et al.: Vet. Med., 67, 77 (1972), Hikasa, Y., et al.: J. Pharmacol. Exp. Ther., 261, 746 (1992), Arce, V., et al.: Brain Res., 537, 359 (1990),