APIs for research and impurities

Trandolaprilat methyl ester is an analytical grade chemical and pharmaceutical intermediate. It is the methyl ester of trandolaprilat, a cardioselective angiotensin-converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure. Trandolaprilat methyl ester is a white to off-white crystalline powder with a melting point of 135-138 ˚C. It is soluble in methanol and ethanol, but insoluble in water. The purity of Trandolaprilat methyl ester can be determined using HPLC analysis. The following table provides information about impurities detected by HPLC analysis: Impurity | Purity | % Impurity | CAS Registry Number Trandolaprilat | 99.8% | 0.2% | 118194-41-5 Methyl acetate | 0.2% | 0

Please enquire for more information about 15-O-Demethyl Tacrolimus including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007), Roy, K., et al.: Eur. J. Med. Chem., 44, 1941 (2009),

Taxol is a natural product that can be found in the bark of the Pacific yew tree. It has been shown to have synergistic effects with 5-HT2A receptor antagonists, such as gamma-aminobutyric acid (GABA) and 5-hydroxytryptamine (5-HT). Taxol has been used in the treatment of cancer, specifically breast cancer. In addition, it has been shown to have an effect on cardiac function by interfering with neurotransmission. This drug also blocks 5-HT2C receptors and is a human protein.

Please enquire for more information about 2-[(2-Cyclopentylphenoxy)methyl]-oxirane including the price, delivery time and more detailed product information at the technical inquiry form on this page

Act 373898 disodium (A37) is a custom synthesis drug product that is used as an analytical standard for the metabolism of actiomycin D. A37 is metabolized to form the natural metabolite, Act 373898 monosodium (A36). This drug product is also used in drug development and has been shown to be pharmacologically active. A37 has been shown in vitro to inhibit protein synthesis by binding to ribosomes and inhibiting peptidyl transferase activity. A37 is not a natural compound but it does possess niche properties. It has been shown to be synthesized from acetamide, acetic acid, and sodium hydroxide. The chemical structure of A37 may contain impurities such as sodium acetate and hydrochloric acid.

Impurity Levofloxacin USP Related Compound F Applications Nonfluorinated analog of Levofloxacin (L360000). Levofloxacin USP Related Compound F. References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980), Fujita, M., et al.: Chem. Pharm. Bull., 44, 987 (1996), Graul, A., et al.: Drugs Future, 24, 1324 (1999), Takahata, M., et al.: Antimicrob. Agents Chemother., 43, 1077 (1999),

Applications Nimbin (N476280) derivative. References Cohen, E., et al.: Life Sci., 58, 1075 (1996), Roy, A., et al.: Biol. Pharm. Bull., 29, 191 (2006),

Tyrosol is a phenolic compound found in olive oil and other plant sources. It has been shown to have antioxidant, anti-inflammatory, and anti-cancer activities. Tyrosol glucuronide is the main form of tyrosol found in urine samples. The absorption process of tyrosols is due to their uptake by the liver cells, where they are converted into fatty acids and then conjugated with glucuronic acid. Tyrosols are also metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Studies have shown that tyrosols can help lower blood pressure and improve insulin resistance in women.

N-Desethyl-E-clomiphene hydrochloride is a synthetic drug product that has been custom synthesized to meet the needs of our customer. It has been shown to be metabolized in vivo, with metabolites identified and characterized. This drug product is a synthetic, natural, and impurity standard. Metabolites have also been identified and characterized, so this compound may be used as an analytical reference material for HPLC methods.

2,2',3,4,6,6'-Hexachlorobiphenyl is an analog of polychlorinated biphenyls (PCBs), which are toxic pollutants that have been widely used in industrial applications. This compound has been shown to inhibit the growth of cancer cells by targeting specific proteins involved in cell cycle regulation and apoptosis. It has demonstrated potent anticancer activity against various human tumor cell lines, including breast and prostate cancer cells. 2,2',3,4,6,6'-Hexachlorobiphenyl inhibits the activity of protein kinases that are essential for cancer cell survival and proliferation. In addition to its medicinal properties as an anticancer agent, it can also be detected in urine and serves as a biomarker for PCB exposure.

Compounds with other nitrogen function, nesoi

Lamivudine epimer

Please enquire for more information about (S,R)-Cis-clopidogrel-mp derivative including the price, delivery time and more detailed product information at the technical inquiry form on this page

Sar-[D-Phe8]-des-Arg9-bradykinin is a selective Bradykinin B1 receptor agonist that exhibits resistance to aminopeptidase cleavage. This peptide plays a crucial role in various physiological processes, including inflammation, pain perception, and angiogenesis. Sar-[D-Phe8]-des-Arg9-bradykinin has been shown to have potent hypotensive effects and can stimulate the release of prostaglandins and nitric oxide. It is resistant to endopeptidase cleavage, making it an ideal candidate for therapeutic applications. Additionally, this peptide has been found to possess antibacterial properties against certain bacteria strains. Sar-[D-Phe8]-des-Arg9-bradykinin is available in pure form with minimal impurities, ensuring its efficacy and safety for use in research and medical applications.

Paclitaxel breakdown product