Amino Acids (AA)

Applications A degradation product of Orlistat (O686500). References Stalder, H. et al.: Helv. Chim. Acta, 73, 1022 (1990);

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Applications 3-Bromo-4-methoxybenzoyl Chloride is an intermediate in the synthesis of (3-Bromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-methanone (B685230), which is an impurity of benzbromarone (B185200) and is currently being investigated as a potent human uric acid (U829200) transporter I inhibitor. References Wempe, M, et al.: Drug Des. Devel. Ther., 6, 323 (2012)

Boc-L-4-Aminophenylalanine is an amino acid that has been shown to be synthesized by cancer cells in breast cancer cell lines, and can also be conjugated with anticancer drugs. It has been shown to have a high affinity for cancer cells. Boc-L-4-Aminophenylalanine is a substrate for L type amino acid transporters and can be used for the treatment of breast cancer. This compound may also be useful in the treatment of other cancers due to its ability to inhibit the uptake of endogenous amino acids.

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Stability Light Sensitive Applications 2-Methoxyphenol (CAS# 90-05-1) is useful for testing ruthenium- and palladium-containing catalysts activity via guaiacol hydrogenation. References Shakirov, I. I., et al.: Pet. Chem., 60, 1136 (2020)

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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3-[(4-Amino-3-methylphenyl)azo]benzenesulfonic acid is an organic compound that is soluble in water. It has a high affinity for the aromatic amines found in mulching and is used as a microprocessor decontaminant. 3-[(4-Amino-3-methylphenyl)azo]benzenesulfonic acid can be used to measure the diameter of covid-19 pandemic cavities, which are small openings on the surface of teeth that may not be visible to the naked eye. 3-[(4-Amino-3-methylphenyl)azo]benzenesulfonic acid crystallizes as a cellulose derivative with a sheet structure and has been shown to have low light optical properties. This compound can also be synthesized using filamentous bacteria or by chemical means and is used in optical sensors.

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Applications N-Phenylglycine is a derivative of Glycine (G615990). N-Phenylglycine is also sometimes coupled with Glycidyl methacrylate to create a surface active comonomer that promotes adhesive bonding of materials to hard tooth tissues. References Bowen, R.., et al.: J. Dent. Res., 44, 903 (1965); Causton, B., et al.: J. Dent. Res., 60, 1321 (1981)

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N,N-Dibenzylglycine is a synthetic drug that is used as a diuretic and to treat congestive heart failure and edema. It is an analog of the amino acid glycine in which the hydrogen atom on the nitrogen atom has been replaced by a benzyl group. The chemical structure of this molecule provides for a natriuretic effect by increasing sodium excretion through the kidneys. N,N-Dibenzylglycine has been shown to inhibit skin cancer cells in mice and may have potential as a treatment for human cancers. This compound is made from ethyl esters and benzyl groups, which form an asymmetric synthesis reaction mechanism with cross-coupling. This drug also exhibits coordination geometry that allows it to bind to metal ions such as zinc or copper.

Antho-RFamide Pyr-Gly-Arg-Phe-NH2 is an acidic amino acid. It has been shown to be a precursor of dopamine β-hydroxylase, which is a key enzyme in the synthesis of epinephrine and norepinephrine. This compound has a diameter of 0.8 nm, and it's been observed in cnidarians and multicellular animals. The biological function of Antho-RFamide Pyr-Gly-Arg-Phe-NH2 is not yet known, but it has been sequenced and identified as fatty acid with a sequence that is identical to serotonin. Analysis shows that this molecule contains an acidic environment with an alkaline pH.

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Applications 1-Methyluracil (cas# 615-77-0) is a compound useful in organic synthesis.

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5-(p-Methylphenyl)-5-phenylhydantoin (MPH) is a hydantoin derivative that has been used in the treatment of epilepsy and other neurological disorders. It is metabolized to phenytoin, its active form, with a half-life of about 10 hours. The clinical use of MPH was limited due to its high levels of toxicity and the need for frequent blood monitoring. A new analytical method has been developed for the determination of MPH in human serum. This method uses liquid chromatography coupled with chemical ionization, followed by mass spectrometry analysis. Validation studies have shown that this method is reliable and accurate for determining the concentration of MPH in human serum.

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M06253 - Fmoc-Lys(Dde)-OH

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5,6-Diamino-1,10-phenanthroline (DAPh) is a monoclonal antibody that can be used as a chromatographic method to separate aliphatic hydrocarbons. It has been shown to bind to the nitrogen atoms of an amino acid residue at the active site of diphosphine ligase and inhibit the enzyme's activity. The protonation state of DAPh is pH dependent and changes depending on whether it is in an acidic or basic environment. In an acidic environment, DAPh will have a high affinity for copper ions, which form a copper complex with this compound. This copper complex decreases the stability of DAPh and leads to its decomposition into 5,6-diaminophenazine and phenanthrenequinone.

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(Ala1·3·11·15)-Endothelin-1 trifluoroacetate salt H-Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu) is a phorbol ester, which is an analog of endothelin. It has been shown to inhibit the production of proinflammatory cytokines and chemokines in vitro and in vivo. This compound also inhibits the migration and proliferation of vascular endothelial cells, which may be due to its ability to suppress Ca2+ concentration. (Ala1·3·11·15)-Endothelin -1 trifluoroacetate salt H-) can also be used as a fluorescent marker for immunohistochemical studies on tissues such as vessels and gastrointestinal tissues. The localization of this drug can be observed by microscopy techniques such as

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Fmoc-Asp(EDANS)-OH is a peptide that inhibits foot-and-mouth disease virus. It is a constant, which means it has the same amino acid sequence in all species. Fmoc-Asp(EDANS)-OH binds to the lipoprotein receptor on the surface of cells and inhibits viral infection. This inhibitor has shown inhibitory concentration values against foot-and-mouth disease virus (FMDV) in cell culture assays. Fmoc-Asp(EDANS)-OH also inhibits ns3 protease and hepatitis C virus (HCV) protease activity, but does not show any inhibitory effect on other serine proteases such as trypsin, chymotrypsin, or elastase.

4-Amino-5-aminomethyl-2-methylpyrimidine dihydrochloride is a vitamin B1 derivative that is biosynthesized by marine algal cells. It is active at high concentrations, and has been shown to have an interaction with the active site residues of hydrogen chloride. This analog has been used in genomic analyses and can be detected by mass spectrometry. It also has the ability to inhibit the growth of phytoplankton, which are microscopic plants living near the surface of water. The concentration of 4-amino-5-aminomethyl-2-methylpyrimidine dihydrochloride in seawater can be determined using a constant scaling factor based on plankton biomass.

N,N'-Bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine is an organic compound that is used as a dye. It has a yellow color, which may be altered by the addition of other dyes or pigments. The dyeability of this compound is long term and it has been shown to inhibit the oxidation of wool.

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N-Methyl-N-(Quinolin-6-Ylmethyl)Amine is an amine with a chiral center. It can be synthesized by heating the monomer and reacting it with an imine. The n-terminal amino group of the monomer is then deprotonated and replaced by the quinolinium ylide, yielding N-methyl-N-(quinolin-6-ylmethyl)amine. This reaction is abiotic and does not require any pressure or catalysis. The product has been expressed as a monomer and used to produce polymeric materials for agrochemical applications that are sustainable and environmentally friendly.

2-fluoro-5-methoxybenzaldehyde is an asymmetric synthesis that has been shown to inhibit the growth of cancer cells by inhibiting a protein called MT2. 2-Fluoro-5-methoxybenzaldehyde is a nucleophilic compound and reacts with the electrophilic carbon in the enolate to form a sulfoxide, which can be hydrolyzed by acid. This reaction inhibits cancer cell growth as it prevents cellular metabolism and amino acid biosynthesis.

Applications 2-(5-methyl-2-furyl)ethanamine (cas# 30796-85-1) is a useful research chemical.

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Applications 1-[4-[[Tris(1-methylethyl)silyl]oxy]phenyl]ethanone is an intermediate in the synthesis of 1-(4-(2-Cyclobutoxyethyl)phenoxy)-3-(isopropylamino)propan-2-ol (C988245), which is a derivative of Betaxolol (B328000). References Philippe, M.M., et. al.: Am. Chem. Soc., 30, 1003 (1987)

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2-Benzyloxy-6-methoxyacetophenone is a high quality and versatile chemical that can be used as a reagent or building block in organic synthesis. It is an important intermediate in the synthesis of fine chemicals, pharmaceuticals, and other complex compounds. 2-Benzyloxy-6-methoxyacetophenone has been shown to be useful as a scaffold for the synthesis of novel complex molecules, such as speciality chemicals. The compound also has potential applications in research and development of new drugs.

1-Bromo-2-iodo-3-methoxybenzene is a synthetic chemical that is used in the synthesis of indoles and furan derivatives. It can be prepared by coupling 1,2-dibromobenzene with 3-iodopropane. This reaction can be catalyzed by palladium to yield 1,2,3-triiodobenzene. The methoxy group on the bromine atom makes it selective for this type of reaction and also allows for the selective removal of the bromine atom from the molecule using hydrogen peroxide. 1,2,3-Triiodobenzene is then converted to 1-bromo-2-iodo-3-methoxybenzene by reacting it with sodium methoxide in methanol. This product has been shown to be synthetically useful in a number of reactions such as those involving indoles or furan derivatives.

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