CAS: 2070015-04-0

Stability Hygroscopic Applications A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic. References De Vos, C., et al.: Ann. Allergy, 59, 278 (1987), Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987), Fadel, R., et al.: Clin. Allergy, 17, 373 (1987), Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)

Cetirizine D8 dihydrochloride is a deuterated H1-antihistamine with long-acting effects.

Cetirizine-d8 is a stable, non-radioactive isotope that has been identified as an optimal tracer for monitoring the fate and transport of cetirizine in ecosystems. The quantification of cetirizine-d8 has been optimized for use as a target substance in environmental monitoring studies. The compound is stable and does not degrade when exposed to the environment, making it well suited for long-term studies. Cetirizine-d8 can be quantified by high-resolution mass spectrometry and has been shown to be a suitable tracer for studying the effect of matrix on analytical measurements. For this reason, it is hypothesized that cetirizine will be useful as an analytical standard in future studies involving natural organic matter.