CAS: 396669-02-6

6-Aza-2'-deoxyisocytidine (6-Aza-dC) is a nucleoside analog that inhibits the activity of the enzyme phosphodiesterase. It has been shown to be effective against HIV, HBV, and HCV by inhibiting viral replication in cells. 6-Aza-dC is an acidic compound that can be synthesized from 2',3'-dideoxycytidine (2',3'-ddC) by reacting with azidotrimethylsilane in the presence of tetraethylammonium chloride. The synthesis of 6-Aza-dC can be accomplished using a phosphoramidite approach or bidentate coupling.