Zellzyklus/Checkpoint
Zellzyklus-/Checkpoint-Inhibitoren sind Verbindungen, die den normalen Verlauf des Zellzyklus, insbesondere an wichtigen regulatorischen Kontrollpunkten, stören. Diese Inhibitoren sind entscheidend für das Studium der Zellteilung, das Verständnis der Krebszellproliferation und die Entwicklung von Krebstherapien. Durch das Targeting spezifischer Phasen des Zellzyklus können diese Inhibitoren einen Zellzyklusarrest induzieren, der in schnell teilenden Zellen zu Apoptose oder Seneszenz führt. Bei CymitQuimica bieten wir eine breite Palette hochwertiger Zellzyklus-/Checkpoint-Inhibitoren zur Unterstützung Ihrer Forschung in der Krebsbiologie, Zellbiologie und Arzneimittelentwicklung an.
Unterkategorien von "Zellzyklus/Checkpoint"
- Aurorakinase
- CDK
- Zellzyklus-Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptose
- HSP
- Integrin
- Kinesin
- KSP
- LIM-Kinase
- Mikrotubuli-assoziiert
- PKC
- PLK
- Rho
- ROCK
- Wee1
11 weitere Unterkategorien anzeigen
Produkte von "Zellzyklus/Checkpoint"
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LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Formel:C16H14FN5O2Reinheit:98.43%Farbe und Form:SolidMolekulargewicht:327.31CDK2-IN-39
CAS:CDK2-IN-39 (compound 4) is a CDK2 inhibitor.Formel:C14H15N3O4SFarbe und Form:SolidMolekulargewicht:321.352COH29
CAS:COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.Formel:C22H16N2O5SReinheit:97.04% - 98.92%Farbe und Form:SolidMolekulargewicht:420.44Ref: TM-T3157
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg217,00€50mg354,00€100mg590,00€1mL*10mM (DMSO)87,00€5'-Azido-5'-deoxythymidine
CAS:5'-Azido-5'-deoxythymidine is a nucleoside analog with potential anti-tuberculosis activity and an inhibitor of TMPKmt in Mycobacterium tuberculosis.Formel:C10H13N5O4Reinheit:99.85%Farbe und Form:SolidMolekulargewicht:267.24NSC23005 Sodium
CAS:NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Formel:C13H16NNaO4SReinheit:99.64%Farbe und Form:SolidMolekulargewicht:305.32Ref: TM-T3589
1mg47,00€2mg59,00€5mg93,00€10mg115,00€25mg245,00€50mg437,00€100mg625,00€1mL*10mM (DMSO)93,00€CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formel:C23H27FN4O4Reinheit:98%Farbe und Form:SolidMolekulargewicht:442.48BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
CAS:BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (Formel:C41H45Cl3N4O5Reinheit:98%Farbe und Form:SoildMolekulargewicht:780.18TASIN-1 Hydrochloride
CAS:TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncatedFormel:C18H29ClN2O3SReinheit:99.84%Farbe und Form:SolidMolekulargewicht:388.95Ref: TM-T24855
1mg78,00€5mg143,00€10mg197,00€25mg335,00€50mg477,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)150,00€Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).Formel:C27H32F2N8·CH4O3SReinheit:98.69% - 99.44%Farbe und Form:SolidMolekulargewicht:602.7CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formel:C24H22FN7O2Farbe und Form:SolidMolekulargewicht:459.48WRN inhibitor 12
CAS:WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formel:C33H33ClF3N9O5Farbe und Form:SolidMolekulargewicht:728.12Cilengitide TFA
CAS:Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Formel:C29H41F3N8O9Farbe und Form:SolidMolekulargewicht:702.68WAY-322243
CAS:WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Formel:C18H18N2O2SReinheit:99.47%Farbe und Form:SoildMolekulargewicht:326.41TP-353
CAS:TP-353 (EOS-61973) is a CDK7 inhibitor.Formel:C35H30FNO3Reinheit:99.12%Farbe und Form:SolidMolekulargewicht:531.62Ref: TM-T22440
1mg59,00€2mg80,00€5mg108,00€10mg187,00€25mg341,00€50mg472,00€100mg652,00€200mg899,00€1mL*10mM (DMSO)158,00€CDK12/13 ligand 1
CAS:ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formel:C26H26BrN5OFarbe und Form:SolidMolekulargewicht:504.42D-I03
CAS:D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM.Formel:C23H36N6SReinheit:99.04%Farbe und Form:SolidMolekulargewicht:428.64Ref: TM-T10936
1mg37,00€2mg52,00€5mg77,00€10mg126,00€25mg283,00€50mg390,00€100mg567,00€1mL*10mM (DMSO)85,00€NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFormel:C38H43N3O6Reinheit:99.16% - 99.27%Farbe und Form:SolidMolekulargewicht:637.76Ref: TM-T9093
1mg87,00€5mg187,00€10mg298,00€25mg525,00€50mg747,00€100mg1.017,00€1mL*10mM (DMSO)264,00€WEE1-IN-11
CAS:WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Formel:C26H29FN8OS2Farbe und Form:SolidMolekulargewicht:552.69Blinatumomab
CAS:Blinatumomab (AMG-10,MT-103) is a CD19/CD3 bispecific B-cell and T-cell binding antibody that in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.Farbe und Form:LiquidAPE1-IN-1
CAS:APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cellsFormel:C19H21N3OS2Reinheit:98.50%Farbe und Form:SolidMolekulargewicht:371.52
