FXR
Der Farnesoid-X-Rezeptor (FXR) ist ein nuklearer Rezeptor, der eine Schlüsselrolle bei der Regulierung der Gallensäurehomöostase, des Lipidstoffwechsels und der Glukoseregulation spielt. FXR ist ein potenzielles therapeutisches Ziel zur Behandlung von Lebererkrankungen, Stoffwechselstörungen und Herz-Kreislauf-Erkrankungen. FXR-Inhibitoren können diese Signalwege modulieren und bieten Einblicke in Krankheitsmechanismen und therapeutische Strategien. Bei CymitQuimica bieten wir eine Reihe von FXR-Inhibitoren an, um Ihre Forschung in den Bereichen Hepatologie, Stoffwechsel und Wirkstoffentwicklung zu unterstützen.
Produkte von "FXR"
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Tropifexor
CAS:Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.Formel:C29H25F4N3O5SReinheit:99.1% - 99.85%Farbe und Form:SolidMolekulargewicht:603.58Ref: TM-T4379
1mg87,00€5mg166,00€10mg248,00€25mg437,00€50mg665,00€100mg1.008,00€200mg1.520,00€500mg2.252,00€1mL*10mM (DMSO)213,00€T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Formel:C17H12F9NO3SReinheit:98% - 99.58%Farbe und Form:SolidMolekulargewicht:481.33Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formel:C21H28O2Reinheit:99.40% - 99.8%Farbe und Form:Light Yellow PowderMolekulargewicht:312.45Ref: TM-T5574
1mg35,00€5mg55,00€10mg93,00€25mg178,00€50mg245,00€100mg360,00€200mg532,00€1mL*10mM (DMSO)60,00€FXR agonist 10
FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.Formel:C15H22O4Farbe und Form:SolidMolekulargewicht:266.33Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Formel:C22H34O7Reinheit:98.83% - 99.86%Farbe und Form:Less Crystalline Solid Colorless Crystalline SolidMolekulargewicht:410.5Ref: TM-T2939
5mg43,00€10mg56,00€25mg86,00€50mg96,00€100mg144,00€200mg182,00€500mg306,00€1mL*10mM (DMSO)56,00€LZ-007
CAS:LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.Formel:C27H29F3N2O5Farbe und Form:SolidMolekulargewicht:518.53LY2562175
CAS:LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).Formel:C28H27Cl2N3O4Reinheit:99.16% - 99.78%Farbe und Form:SolidMolekulargewicht:540.44Ref: TM-T15806
1mg104,00€5mg227,00€10mg369,00€25mg740,00€50mg1.169,00€100mg1.568,00€200mg2.118,00€1mL*10mM (DMSO)269,00€Lecufexor
CAS:Lecufexor is an agonist of the farnesoid X receptor (FXR).Formel:C32H21Cl3N2O5Farbe und Form:SolidMolekulargewicht:619.88FXR agonist 11
CAS:FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.Formel:C18H16N2O5Farbe und Form:SolidMolekulargewicht:340.33FXR agonist 9
CAS:FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.Formel:C28H30N2O5Farbe und Form:SolidMolekulargewicht:474.55Vonafexor
CAS:Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effectsFormel:C19H15Cl3N2O5SReinheit:98.74%Farbe und Form:SolidMolekulargewicht:489.76Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.Formel:C24H40O4Reinheit:99.74% - ≥95%Farbe und Form:White - Almost White Solid PowderMolekulargewicht:392.57Ursodeoxycholic acid sodium
CAS:Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.Formel:C24H40NaO4Reinheit:98% - 98.55%Farbe und Form:SolidMolekulargewicht:415.56NR1H4 Protein, Mouse, Recombinant (His)
NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.Farbe und Form:Lyophilized PowderMolekulargewicht:27.80 kDa (predicted)Sevelamer hydrochloride
CAS:Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorptionFormel:(C3H7N·C3H5ClO·HCl)xReinheit:98%Farbe und Form:SolidMolekulargewicht:186.08BAR-2227
CAS:BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.Formel:C24H17Cl2NO4Farbe und Form:SolidMolekulargewicht:454.30INT-767
CAS:INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial functionFormel:C25H43NaO6SReinheit:98%Farbe und Form:SolidMolekulargewicht:494.66Obeticholic Acid
CAS:Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.Formel:C26H44O4Reinheit:99.88% - 99.97%Farbe und Form:SolidMolekulargewicht:420.63Ref: TM-T1789
5mg48,00€10mg52,00€25mg82,00€50mg99,00€100mg163,00€200mg274,00€500mg505,00€1mL*10mM (DMSO)49,00€Vidofludimus
CAS:Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).Formel:C20H18FNO4Reinheit:98.83% - 99.58%Farbe und Form:SolidMolekulargewicht:355.36Cilofexor
CAS:Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Formel:C28H22Cl3N3O5Reinheit:99.32% - ≥95%Farbe und Form:SolidMolekulargewicht:586.85Ref: TM-T7436
1mg50,00€2mg73,00€5mg124,00€10mg188,00€25mg380,00€50mg567,00€100mg807,00€500mg1.644,00€1mL*10mM (DMSO)158,00€
