Trk-Rezeptor
Trk-Rezeptor-Inhibitoren zielen auf die Tropomyosin-Rezeptor-Kinasen (Trk), eine Familie von Rezeptor-Tyrosinkinasen, die eine bedeutende Rolle bei der Entwicklung und Funktion des Nervensystems spielen. Trk-Rezeptoren sind an der Neurotrophin-Signalgebung beteiligt, die für das Überleben, die Differenzierung und das Wachstum von Neuronen unerlässlich ist. Eine Fehlregulation der Trk-Signalgebung ist mit neurologischen Störungen und bestimmten Krebsarten verbunden. Bei CymitQuimica bieten wir Trk-Rezeptor-Inhibitoren an, um Ihre Forschung in den Bereichen Neurobiologie, Onkologie und neurodegenerative Erkrankungen zu unterstützen.
Produkte von "Trk-Rezeptor"
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TRK II-IN-1
CAS:TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.Formel:C29H31F3N8OReinheit:98%Farbe und Form:SolidMolekulargewicht:564.6BNN-20
CAS:BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.Formel:C20H30O2Farbe und Form:SolidMolekulargewicht:302.45Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formel:C31H34F2N6O2Reinheit:98.03% - 99.61%Farbe und Form:SolidMolekulargewicht:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Formel:C29H35F2N7O6SReinheit:98%Farbe und Form:SolidMolekulargewicht:647.69Sitravatinib
CAS:Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, andFormel:C33H29F2N5O4SReinheit:98.9% - 99.74%Farbe und Form:SolidMolekulargewicht:629.68Ref: TM-T4349
5mg51,00€10mg79,00€25mg137,00€50mg210,00€100mg338,00€200mg535,00€500mg845,00€1mL*10mM (DMSO)72,00€GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Formel:C28H21F4N5O2Reinheit:96.17% - 99.29%Farbe und Form:SolidMolekulargewicht:535.49Ref: TM-T6097
5mg50,00€10mg85,00€25mg124,00€50mg188,00€100mg311,00€200mg404,00€500mg657,00€1mL*10mM (DMSO)56,00€ALE-0540
CAS:ALE-0540: nonpeptidic heterocycle, blocks NGF binding to p75/TrkA and TrkA-mediated signaling.Formel:C14H11N3O5Reinheit:97.25%Farbe und Form:SolidMolekulargewicht:301.25Ref: TM-T9292
2mg35,00€5mg55,00€10mg88,00€25mg133,00€50mg188,00€100mg269,00€200mg369,00€1mL*10mM (DMSO)60,00€TrkB-IN-1
CAS:TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.Formel:C19H16N2O6Reinheit:98%Farbe und Form:SolidMolekulargewicht:368.34Type II TRK inhibitor 1
CAS:Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.Formel:C35H33F3N8O3Reinheit:98%Farbe und Form:SolidMolekulargewicht:670.68TrkA-IN-1
CAS:TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.Formel:C25H20N4OReinheit:98%Farbe und Form:SolidMolekulargewicht:392.45Protein kinase inhibitor 5
CAS:Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].Formel:C29H31F2N7OReinheit:98%Farbe und Form:SolidMolekulargewicht:531.6CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formel:C32H31N3O5SReinheit:99.92%Farbe und Form:SolidMolekulargewicht:569.67Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formel:C20H21FN6OReinheit:99.55% - ≥95%Farbe und Form:SolidMolekulargewicht:380.42PF-06273340
CAS:PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。Formel:C23H22ClN7O3Reinheit:98% - 98.00%Farbe und Form:SolidMolekulargewicht:479.92ENT-C225
CAS:ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.Formel:C26H40N4O5Reinheit:99.16% - 99.16%Farbe und Form:SolidMolekulargewicht:488.62ONO-7475
CAS:ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFormel:C32H26N4O6Reinheit:98.74%Farbe und Form:SolidMolekulargewicht:562.57ANA-12
CAS:ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.Formel:C22H21N3O3SReinheit:99.28% - 99.87%Farbe und Form:SolidMolekulargewicht:407.49NMS-P626
CAS:NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.Formel:C28H35F2N7O4SFarbe und Form:SolidMolekulargewicht:603.68Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formel:C21H22F2N6O2Reinheit:100% - 99.15%Farbe und Form:SolidMolekulargewicht:428.44Ref: TM-T5995
1mg39,00€5mg79,00€10mg96,00€25mg165,00€50mg250,00€100mg376,00€500mg867,00€1mL*10mM (DMSO)86,00€LM22B-10
CAS:LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formel:C27H33ClN2O4Reinheit:98.18%Farbe und Form:SolidMolekulargewicht:485.01
