Metallorganische Liganden

6-OAU is a chemical compound categorized as a cytokinin-like molecule, which is derived from natural plant sources. It functions by modulating gene expression and hormone pathways involved in various plant growth and developmental processes. The mode of action of 6-OAU largely revolves around mimicking the activity of cytokinins, essential plant hormones that regulate cell division, shoot and root growth, as well as delay senescence. 6-OAU finds substantial application in agricultural and biological research due to its ability to influence plant morphology and stimulate growth under specific conditions. By altering hormonal balances, it allows scientists to explore plant developmental pathways, investigate stress responses, and enhance crop yields in controlled research settings. Its application in vitro aids in understanding plant tissue culture efficacy, serving as a valuable tool for developing robust plant regeneration protocols. In summary, 6-OAU remains a significant phytochemical for scientists studying plant physiology and biochemistry.

Ketanserin is a 5-HT2A serotonin receptor antagonist that is used for the treatment of hypertension. This drug is also used in research to study the serotonergic system. Ketanserin has been found to also block the vesicular monoamine transporter 2. Ketanserin tartrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

BIX is an NHE1 inhibitor, which is a small molecule compound derived from chemical synthesis. It specifically targets the Na+/H+ exchanger 1 (NHE1), a protein involved in the regulation of intracellular pH. The mode of action of BIX involves the inhibition of NHE1, leading to altered proton exchange across the plasma membrane. This action affects the cellular pH homeostasis and ion balance, which can influence various cellular processes such as cell proliferation, apoptosis, and migration. The applications of BIX are primarily in the field of biomedical research, where it is utilized to study the physiological and pathological roles of NHE1 in different cell types and tissues. It is particularly significant in cancer research, where NHE1 activity is often upregulated, contributing to the malignant phenotype. By understanding the effects of BIX, researchers can explore the potential therapeutic implications of targeting NHE1 in tumor progression, cardiovascular diseases, and other conditions influenced by dysregulated pH dynamics.

Prasugrel is a thienopyridine prodrug that inhibits the enzyme ADP-dependent P2Y purinergic receptor. Prasugrel inhibits platelet aggregation and the formation of blood clots by blocking the conversion of ADP to ATP on the surface of platelets, thus preventing the release of serotonin from platelets. The reaction products formed by prasugrel are similar to those formed by clopidogrel and include hydrogen sulfate ions and a thiol-containing metabolite. It has also been shown to have potent cytotoxic activity against melanoma cells and anti-inflammatory properties.  Prasugrel is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

ABP 688 is a radiolabeled ligand, which is a synthetic compound used primarily in positron emission tomography (PET) to visualize metabotropic glutamate receptor subtype 5 (mGluR5) in vivo. Developed from chemical synthesis, ABP 688 acts by selectively binding to the allosteric site of the mGluR5 receptor with high affinity and specificity. When labeled with a positron-emitting isotope such as Carbon-11 or Fluorine-18, it allows for the non-invasive imaging and quantification of mGluR5 distribution and density in the brain. The primary use of ABP 688 is in neuroscience research, where it aids in the study of neurological and psychiatric disorders associated with glutamatergic dysfunction, such as schizophrenia, depression, and addiction. By providing detailed insights into mGluR5 expression patterns, this radioligand facilitates the understanding of pathophysiological mechanisms and the evaluation of therapeutic interventions targeting mGluR5. ABP 688 is not used for therapeutic purposes but remains a crucial tool in translational research bridging preclinical studies and human clinical trials.

A-889425 is a novel small molecule compound that serves as a potent and selective antagonist. It is derived from synthetic chemical processes aimed at modulating ion channel activity specifically. The mode of action of A-889425 involves the selective inhibition of specific ion channels, which play critical roles in cellular signaling pathways and are implicated in various physiological processes. By selectively targeting certain ion channels, A-889425 demonstrates significant potential in altering cellular excitability and signal transduction, making it a valuable tool in both basic research and potential therapeutic contexts. Its applications are primarily concentrated in the investigation of channelopathies-diseases resulting from disturbed ion channel function-and in the development of novel treatments for conditions such as chronic pain, epilepsy, and cardiovascular disorders. Researchers utilize A-889425 in in vitro and in vivo studies to delineate the precise roles of specific ion channels and to explore the therapeutic windows of intervention. Its high specificity and efficacy make A-889425 an indispensable molecule in the arsenal of molecular pharmacology and neurobiological research.

Retosiban is a pharmaceutical compound that serves as an oxytocin receptor antagonist, derived through synthetic chemical synthesis. Its primary mechanism of action involves the selective inhibition of oxytocin receptors, which are critical in the uterine contractions that occur during labor. By blocking these receptors, Retosiban effectively reduces uterine muscle contractions, thus playing a crucial role in managing preterm labor. The primary application of Retosiban is in the obstetric field, where it is used to delay preterm birth by reducing the frequency, intensity, and duration of uterine contractions. This can help to prolong pregnancy, allowing for further fetal development and reducing risks associated with premature delivery. Although still under investigation in various clinical trial stages, Retosiban holds promise as a significant intervention for improving neonatal outcomes in pregnancies at risk of preterm birth. Research continues to assess its efficacy, safety profile, and potential long-term impacts on both maternal and fetal health.

Bicuculline is a phthalide-isoquinoline compound and is a competitive GABA receptor antagonist. It blocks GABA’s inhibitory action, mimicking epilepsy. This compound is used in research to better study epilepsy. (+)-Bicuculline is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Brobactam sodium is a β-lactamase inhibitor, which is a chemically synthesized compound with the primary function of inactivating β-lactamase enzymes produced by certain bacteria. These enzymes can degrade β-lactam antibiotics, such as penicillins and cephalosporins, rendering them ineffective. Brobactam sodium functions by forming a covalent bond with the active site of β-lactamase enzymes, thus inhibiting their activity and allowing the concomitantly administered β-lactam antibiotic to exert its bactericidal effect on the susceptible pathogens. The primary application of Brobactam sodium is in combination therapies with β-lactam antibiotics to treat infections caused by β-lactamase-producing bacteria. This includes a range of Gram-positive and Gram-negative bacteria that are otherwise resistant to standard β-lactam antibiotics alone. Its use is critical in both clinical and research settings to study antibiotic resistance mechanisms and to develop effective therapeutic strategies against resistant bacterial infections.

17:0-20:4Pi (4) P is a synthetic phosphoinositide, which is a type of phospholipid. It is typically sourced from laboratory synthesis, often incorporating stable isotopes or specific fatty acid chains to mimic natural compounds found in cell membranes. This product functions primarily as a probe in biochemical experiments, particularly for studying lipid signaling pathways within cells. The main mode of action of 17:0-20:4Pi (4) P involves its incorporation into cellular membranes where it participates in signaling processes by interacting with specific proteins that recognize phosphoinositides. These interactions are crucial for the regulation of various cellular activities, such as membrane trafficking, cytoskeletal rearrangement, and intracellular signaling cascades. The uses and applications of 17:0-20:4Pi (4) P are extensive in the field of cell biology and biochemistry. Researchers employ this compound to investigate the roles of phosphoinositides in various physiological and pathological contexts, including cancer, neurodegenerative diseases, and immune responses. Additionally, it serves as a valuable tool in the development of assays and in the exploration of potential therapeutic targets within lipid signaling pathways.

Perfluorophenyl 3-(2-(2-(3-(2,5-dioxo-2H-pyrrol-1(5H)-yl)propanamido)ethoxy)ethoxy)propanoate is a specialized chemical compound, belonging to the class of fluorinated organic esters. It is derived synthetically through a series of controlled chemical reactions involving perfluorophenyl groups and functionalized pyrrolidone derivatives. The presence of perfluorinated groups imparts unique physicochemical properties to the compound, including chemical inertness and hydrophobicity. This compound functions as a reactive agent in materials science and industrial applications. Its mode of action is primarily based on its ability to engage in specific interactions at a molecular level, making it an excellent candidate for surface modifications, particularly in engineering nanocomposites and advanced coatings. Applications of Perfluorophenyl 3-(2-(2-(3-(2,5-dioxo-2H-pyrrol-1(5H)-yl)propanamido)ethoxy)ethoxy)propanoate are broad and include enhancing the performance of polymer matrices, serving as a coupling agent, and improving the durability and water-resistance of materials. It is highly valued in research fields exploring advanced material properties, requiring precise, high-performance modifications.

Bostrycin is a polyketide-type natural product, which is a secondary metabolite produced by certain fungi, particularly those belonging to the genus Aschersonia. Its source lies in the complex biosynthetic pathways of these fungi, which synthesize diverse polyketides with bioactive properties. The mode of action of Bostrycin involves disrupting cellular processes, predominantly through the inhibition of specific enzyme activities and interference with DNA processes, which can lead to cell cycle arrest and apoptosis in target cells. In research settings, Bostrycin has garnered interest due to its potential applications in pharmacology, particularly for its anticancer and antibiotic properties. Studies have shown its capacity to modulate cellular responses and inhibit the growth of various cancer cell lines. Furthermore, its antibiotic activity has been explored against several bacterial strains, indicating a potential role in developing new therapeutic agents. While its precise mechanisms continue to be investigated, Bostrycin represents a promising candidate for further study in drug development and biochemical research.

Potent agonist of a1β1γ1 5′-adenosine monophosphate-activated protein kinase (AMPK). It binds to the allosteric drug and metabolite (ADaM) site at the α- and β- subunit interface of AMPK. It has potential for the treatment of diabetic nephropathy. PF 06409577 reduces infections caused by flaviviruses, mediated by changes in the metabolism of lipids in host cells.

NBD 18:0 ceramide is a synthetic fluorescent lipid analogue, which is derived from the naturally occurring sphingolipid, ceramide. This product is characterized by the attachment of a nitrobenzoxadiazole (NBD) fluorophore to the ceramide backbone, allowing it to serve as a tool for visualizing and studying lipid dynamics within biological membranes. The mode of action of NBD 18:0 ceramide involves its incorporation into lipid bilayers, where it can mimic natural ceramides and participate in membrane-related processes, while the attached NBD group provides a fluorescent signal. This fluorescence facilitates the tracking and analysis of ceramide distribution, interaction with other membrane constituents, and roles in cellular signaling pathways. NBD 18:0 ceramide is utilized in various applications, including studies on membrane organization, lipid trafficking, and sphingolipid metabolism. Its ability to integrate into cell membranes without significantly altering their native properties makes it a valuable tool for researchers investigating the functional roles of ceramides in health and disease. Through fluorescence microscopy and spectroscopy, scientists can gain insights into the dynamic behavior of lipids in live cells and model systems.

Antagonist of Wnt signalling pathway by inhibiting the activity of Porcn, a member of the membrane-bound O-acyltransferase (MBOAT) family. Porcn is required for the palmitoylation of Wnt, mediating its secretion and signalling. Inhibits self-renewal in embryonic stem cells, whilst promoting differentiation to epiblast stem cells.

Inhibitor of pan-sirtuins (IC50 = 15, 10, 33 µM for SIRT1, 2 and 3 respectively), by binding to the active catalytic site. Selectivity for sirtuins was demonstrated when tested for activity on a panel of kinases, nuclear receptors, ion channels, transporters and GPCRs.

Doxazosin is a first-generation α1-adrenergic receptor antagonist that is used in the treatment of hypertension and urinary obstruction, It has been shown to be effective in combination therapy for patients with benign prostatic hyperplasia. Doxazosin mesylate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

PT2399 is a delay line integrated circuit, which is a monolithic IC sourced from Princeton Technology Corp. It operates through analog and digital signal processing to achieve time-delay effects in audio signals. The PT2399 utilizes a digital delay line technique, converting analog input signals to digital through an integrated ADC. These digital signals are subsequently delayed and processed internally, after which they are reconverted back into analog form via a built-in DAC. Commonly employed in audio applications, the PT2399 is found in effects units such as guitar pedals, karaoke machines, and other sound processors where echo or delay effects are desired. Its versatility in manipulating audio signals, coupled with relatively low noise and distortion characteristics, makes it a favored component in the design of cost-effective audio equipment. The ability to produce varied delay times through external control means it can be intricately integrated into custom audio processing solutions, providing flexibility and adaptability for advanced acoustic experimentation and application.

Tryphos(R) is a specialized solvent and extractant, derived from organophosphorus compounds. This product originates from a chemically synthesized source, characterized by the complex manipulation of phosphorus chemistry to achieve its specific functional properties. Its mode of action involves the selective solvation and coordination with target molecules, which facilitates the separation or purification of specific compounds via liquid-liquid extraction processes. The applications of Tryphos(R) are diverse, primarily focused on the fields of analytical chemistry and industrial processes. It is utilized for its efficacy in the separation and extraction of metal ions, particularly in the purification of rare earth elements and transition metals. Furthermore, Tryphos(R) is employed in organic synthesis as a reagent that enables specific transformations by stabilizing intermediates or enhancing the reactivity of substrates. Its unique chemical properties make it a vital tool in laboratories and industries seeking precision and efficiency in chemical separations and syntheses.

PPDA is a synthetic chemical compound, which is an aromatic amine derived from aniline through a series of chemical reactions involving nitration and reduction. Its mode of action involves acting as an intermediate or precursor in a variety of organic synthesis processes, playing a pivotal role in the formation of complex organic structures. PPDA's electrophilic properties make it an essential component in producing dyes, polymers, and pharmaceuticals by facilitating specific chemical transformations. Additionally, it demonstrates high reactivity in coupling reactions due to its amine group, enhancing its utility in the synthesis of polymers and advanced materials. In scientific research, PPDA is valuable for its role in producing polymers with tailored properties and for synthesizing pharmaceutical compounds that require precise and efficient chemical modifications. The compound's ability to participate in diverse chemical reactions under controlled conditions makes it indispensable in both industrial and laboratory settings, where it contributes to the innovation of new materials and drug development strategies. Its applications extend to dye production, where it aids in fabricating stable colorants used in various industries.