PAK-Standards (Polyzyklische aromatische Kohlenwasserstoffe)

Applications Acenaphthylene-d8 is labelled Acenaphthylene (A130750) which is a polycyclic aromatic hydrocarbons as carcinogenic agents. References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999), Czub, G., et al.: Environ. Sci. Technol., 38, 2406 (2004),

Applications 6-Nitro-1-pyrenol and 8-Nitro-1-pyrenol are urinary hydroxylated metabolites used as a biomarkers of exposure to polycyclic aromatic hydrocarbons. References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999);

Applications Azulene is an isomer of napthalene visibly identifiable by its dark blue hue. As such it is used in the preparation of dyes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Stirling, A. et al.: ChemPhysChem, 5, 1558 (2004); Zhang, X. et al.: J. Mat. Chem., 17, 642 (2007);

Applications Labelled analogue of Benzo[ghi]perylene, one of the polycyclic aromatic hydrocarbons (PAH’s), an environmental pollutant with potential carcinogenic activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Alves, C. et al.: Atmos. Environ., 35, 5485 (2001); Jaward, F. et al.: Environ. Sci. Technol., 38, 2523 (2004); Lee, R. et al.: Environ. Sci. Technol., 39, 1436 (2005); Augusto, S. et al.: Environ. Pollut., 158, 483 (2010);

Applications Protected Naphthylamine. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Barbay, J., et al.: Bioorg. Med. Chem. Lett.,18, 2544 (2008), Konda, S., et al.: J. Chem. Pharm. Res., 2, 187 (2010),

Applications 6-Aminochrysene is a potent inhibitor of transferase activity. Also, it is used for the synthesis of diarylthiourea analogs as novel anti-cancer agents. References Liu, S., et al.: Bioorg. Med. Chem. Lett., 25, 1301-1305 (2015)

Applications Labelled Chrysene (C428000). Chrysene occurs in coal tar. Is formed during distillation of coal, in very small amount during distillation or pyrolysis of many fats and oils. Chrysene is one of the basic polycyclic aromatic hydrocarbon (PAH) which is toxic environmental pollutant and consistently exposed to sunlight. However, little information is available on its photogenotoxicity.  The objective of the present study was to analyze the effects of Chrysene, under environmental intensity of UVB (0.6 mW/cm2) in human skin epidermal cell line (HaCaT). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Anderson, D., et al.: Mutat. Res., 307, 261 (1994), Diamond, S., et al.: Environ. Toxicol. Chem., 25, 3015 (2006), Fotakis, G., et al.: Toxicol. Lett., 160, 171 (2006),

Applications 9-Acetylanthracene is a polycyclic aromatic hydrocarbon (PAH) with photo-induced toxicity. Biological studies have shown that 9-Acetylanthracene has plasmid curing activity. References Sinks, G.D., et al.: B. Environ. Contam. Tox., 59, 1 (1997); Molnar, J., Biochem. Pharmacol., 28, 261 (1979)