CAS 100239-44-9: 3α-Hidroxytibolona
Descripción:
3α-Hidroxytibolona, con el número CAS 100239-44-9, es un esteroide sintético y un derivado de tibolona, que se utiliza principalmente en la terapia de reemplazo hormonal. Este compuesto exhibe una estructura única que incluye un grupo hidroxilo en la posición 3α, lo que contribuye a su actividad biológica. Se caracteriza por su capacidad para unirse selectivamente a los receptores de estrógeno, imitando así los efectos estrogénicos en ciertos tejidos mientras exhibe propiedades antiestrogénicas en otros. Esta acción selectiva lo hace beneficioso para aliviar los síntomas menopáusicos, como los sofocos y la osteoporosis, al tiempo que minimiza el riesgo de efectos secundarios relacionados con el estrógeno. Además, se ha estudiado el potencial de 3α-Hidroxytibolona en los efectos sobre el metabolismo lipídico y la densidad ósea. Su farmacocinética implica un metabolismo principalmente en el hígado, lo que lleva a metabolitos activos que ejercen efectos terapéuticos. En general, 3α-Hidroxytibolona representa un avance significativo en el desarrollo de moduladores selectivos de los receptores de estrógeno (SERMs) para uso clínico.
Fórmula:C21H30O2
InChI:InChI=1S/C21H30O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,15,17-19,22-23H,5-12H2,2-3H3/t13-,15-,17-,18+,19-,20+,21+/m1/s1
Clave InChI:InChIKey=YLEUWNOTNJZCBN-CZTKNSHGSA-N
SMILES:C[C@H]1[C@]2([C@]3([C@@](C)([C@@](C#C)(O)CC3)CC[C@@]2(C4=C(C1)C[C@H](O)CC4)[H])[H])[H]
Sinónimos:- (3A,7A,17A)-3,17-Dihydroxy-7-Methyl-19-Norpregn-5(10)-En-20-Yl-3-One
- (3α,7α,17α)-7-Methyl-19-norpregn-5(10)-en-20-yne-3,17-diol
- 19-Norpregn-5(10)-en-20-yne-3,17-diol, 7-methyl-, (3α,7α,17α)-
- 3-alpha-Hydroxytibolone
- Org 4094
- 3α-Hydroxytibolone
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Encontrado 6 productos.
3alpha-Hydroxy Tibolone
CAS:Producto controladoApplications A metabolite of Tibolone. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome. References Belman, S., et al.: Cancer Res., 32, 450 (1972), Shirahashi, H., et al.: Chem. Pharm. Bull., 41, 1664 (1993), Hoyte, R., et al.: Steroids, 58, 13 (1993), Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Colombo, D., et al.: Eur. J. Med. Chem., 40, 69 (2005),Fórmula:C21H30O2Forma y color:White To Off-WhitePeso molecular:314.463alpha-Hydroxy Tibolone (1mg/ml in Acetonitrile)
CAS:Producto controladoFórmula:C21H30O2Forma y color:Single SolutionPeso molecular:314.463-Hydroxy Tibolone-d5 (mixture of 3alpha & 3beta isomers)
CAS:Producto controladoApplications 3-Hydroxy Tibolone-d5, is the labeled analogue of 3-Hydroxy Tibolone, a synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Belman, S., et al.: Cancer Res., 32, 450 (1972), Shirahashi, H., et al.: Chem. Pharm. Bull., 41, 1664 (1993), Hoyte, R., et al.: Steroids, 58, 13 (1993), Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Colombo, D., et al.: Eur. J. Med. Chem., 40, 69 (2005),Fórmula:C21H25D5O2Forma y color:NeatPeso molecular:319.493a-Hydroxy tibolone
CAS:Producto controladoTibolone is a synthetic hormone that is used in the treatment of menopausal symptoms and breast cancer. Tibolone has been shown to be an effective treatment for menopausal symptoms, such as hot flashes and vaginal dryness, by providing relief from these symptoms. Tibolone has also been shown to have anti-cancer effects. This drug may be useful for treating breast cancer because it can inhibit the growth of cancer cells by binding to estrogen receptors and blocking estrogen-induced cell proliferation. Tibolone also stimulates angiogenesis, which is the formation of new blood vessels in order to provide nutrients and oxygen to growing tissue. It has been shown that this drug inhibits the synthesis of hepg2 cells in vitro, which are involved in the production of angiogenic factors. Tibolone may also have clinical relevance as a chemopreventive agent against prostate cancer.BR> Tibolone has also been shown to stimulate sulphatase activity in vitro, which may contribute toFórmula:C21H30O2Pureza:Min. 95%Peso molecular:314.46 g/mol3a-Hydroxy Tibolone-13C,d3
CAS:Producto controladoFórmula:C2013CH27D3O2Forma y color:NeatPeso molecular:318.473alpha-Hydroxy Tibolone-13C,d3 (1mg/ml in Acetonitrile)
CAS:Producto controladoFórmula:C2013CH27D3O2Forma y color:Single SolutionPeso molecular:318.47
