CAS 104987-11-3: Tacrolimus
Descripción:
Tacrolimus, con el número CAS 104987-11-3, es un fármaco inmunosupresor utilizado principalmente para prevenir el rechazo de órganos en pacientes trasplantados y para tratar ciertas condiciones autoinmunitarias. Es una lactona macrólida derivada de la bacteria Streptomyces tsukubaensis. Tacrolimus funciona inhibiendo la activación y proliferación de linfocitos T, principalmente a través de la inhibición de la calcineurina, una enzima crítica en la señalización de células T. Este mecanismo ayuda a suprimir la respuesta inmune. La sustancia se administra típicamente en su forma tópica para condiciones de la piel como la dermatitis atópica o como una formulación oral para uso sistémico. Tacrolimus es lipofílico, lo que influye en su absorción y distribución en el cuerpo. Tiene una vida media relativamente larga, lo que requiere un monitoreo cuidadoso de los niveles en sangre para evitar toxicidad. Los efectos secundarios comunes incluyen un mayor riesgo de infecciones, nefrotoxicidad y neurotoxicidad. Debido a sus potentes efectos inmunosupresores, Tacrolimus a menudo se utiliza en conjunto con otros inmunosupresores para mejorar la eficacia mientras se minimizan los efectos adversos.
Fórmula:C44H69NO12
InChI:InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
Clave InChI:InChIKey=QJJXYPPXXYFBGM-LFZNUXCKSA-N
SMILES:O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H]
Sinónimos:- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
- FR 900506
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
- (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
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Encontrado 13 productos.
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
CAS:Fórmula:C44H69NO12Pureza:98%Forma y color:SolidPeso molecular:804.0182Ref: IN-DA0039L0
1g160,00€5g687,00€10gA consultar25gA consultar10mg45,00€50mg50,00€100mg73,00€250mg113,00€Tacrolimus Monohydrate
CAS:Fórmula:C44H69NO12·H2OPureza:>80.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:822.05Tacrolimus
CAS:Antirheumatic; immunosuppressant; neuroprotective; neuroregenerativeFórmula:C44H69NO12Pureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:804.02 g/molFK-506 (Tacrolimus)
CAS:FK-506 is an immunosuppressant that is produced by fermentation. It is used to prevent the rejection of transplanted organs and to treat a number of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. FK-506 binds to the IL-2 receptor on T-cells and inhibits their proliferation, thereby preventing activation of other immune cells. FK-506 has been shown to be effective in treating a number of diseases, including myocardial infarcts, coronary heart disease, and oral hypoglycaemic. The optimum concentration for this drug is not known, but it appears that higher concentrations are more beneficial in treating some conditions.Fórmula:C44H69NO12Pureza:Min. 95%Peso molecular:804 g/molFK-506
CAS:FK-506Fórmula:C44H69NO12Pureza:By hplc: 99.91% (Typical Value in Batch COA)Forma y color: white powderPeso molecular:804.02g/molTacrolimus - Bio-X ™
CAS:Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties. Tacrolimus is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C44H69NO12Pureza:Min. 95%Forma y color:White Off-White PowderPeso molecular:804.02 g/molRef: 4Z-T-391
5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar450mg2.366,00€Tacrolimus
CAS:Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent proteinFórmula:C44H69NO12Pureza:98% - 99.94%Forma y color:White Or Off-White Crystalline PowderPeso molecular:804.02Ref: TM-T2144
10mg46,00€25mg60,00€50mg74,00€100mg104,00€200mg147,00€500mg244,00€1mL*10mM (DMSO)50,00€Everolimus, Cyclosporine and Tacrolimus Mix Standard
CAS:Producto controladoFórmula:C53H83NO14•C62H111N11O12•C44H69NO12Forma y color:MixtureFK-506 (Tacrolimus)
CAS:Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)Fórmula:C44H69NO12Forma y color:NeatPeso molecular:804.02
