CAS 109581-93-3: Hidrato de tacrolimus
Descripción:
Hidrato de tacrolimus, con el número CAS 109581-93-3, es un agente inmunosupresor utilizado principalmente en el trasplante de órganos y enfermedades autoinmunes. Se deriva de la bacteria Streptomyces tsukubaensis y funciona inhibiendo la activación de los linfocitos T, reduciendo así la respuesta inmune. La sustancia aparece como un polvo blanco a blanco amarillento y es soluble en disolventes orgánicos como el metanol y el dimetilsulfóxido, pero tiene una solubilidad limitada en agua. Hidrato de tacrolimus a menudo se formula como un ungüento tópico o medicamento oral, dependiendo de su aplicación. Sus efectos farmacológicos se atribuyen a su capacidad para unirse a FKBP-12, una proteína que posteriormente inhibe la calcineurina, una enzima crítica en la activación de células T. Aunque es efectivo, el tacrolimus puede tener efectos secundarios, incluyendo nefrotoxicidad y mayor susceptibilidad a infecciones, lo que requiere un monitoreo cuidadoso durante el tratamiento. En general, Hidrato de tacrolimus es un agente terapéutico vital en el manejo de condiciones que requieren supresión inmune.
Fórmula:C44H69NO12·H2O
InChI:InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1
Clave InChI:InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N
SMILES:O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H].O
Sinónimos:- (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone hydrate
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, hydrate (1:1), (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
- 18-Tetramethyl-8-(2-Propenyl)-,Monohydrate,(3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*
- 3-(2-(4-Hydroxy-3-Methoxycyclohexyl)-1-Methylethenyl)-14,16-Dimethoxy-9,10,12,Monohydrate
- FK-506 Monohydrate
- Tacforius
- Tacrolimus hydrate
- Tacrolimushydrate
- Tsukubaenolide hydrate
- Ver más sinónimos
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Encontrado 14 productos.
Tacrolimus Monohydrate
CAS:Fórmula:C44H69NO12·H2OPureza:>80.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:822.05Tacrolimus Hydrate
CAS:Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs) Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)Fórmula:C44H69NO12·H2OForma y color:NeatPeso molecular:822.03Tacrolimus monohydrate - Bio-X ™
CAS:Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties. Tacrolimus monohydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C44H69NO12·H2OPureza:Min. 95%Forma y color:PowderPeso molecular:822.03 g/molTacrolimus
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C44H69NO12·H2OForma y color:White PowderPeso molecular:803.48198Tacrolimus monohydrate
CAS:Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.Fórmula:C44H71NO13Pureza:97.04% - 98.05%Forma y color:SolidPeso molecular:822.05FK-506 monohydrate
CAS:Fórmula:C44H69NO12·H2OPureza:≥ 98.0%Forma y color:White to off-white solid or powderPeso molecular:822.03Tacrolimus monohydrate
CAS:Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerativeFórmula:C44H69NO12·H2OPureza:Min. 98 Area-%Forma y color:White PowderPeso molecular:822.03 g/mol
