CAS 109944-15-2: Kifunensina, Kitasatosporia kifunense
Descripción:
Kifunensina es un producto natural derivado del actinobacterium Kitasatosporia kifunense, conocido por su papel como un potente inhibidor de los procesos de glicosilación. Se clasifica como un inhibidor de mannosidasa, dirigido específicamente a la enzima α-mannosidasa, que es crucial en el procesamiento de glicoproteínas. Esta inhibición puede afectar diversas vías biológicas, lo que convierte a la kifunensina en una herramienta valiosa en la investigación bioquímica, particularmente en estudios relacionados con el plegamiento de proteínas y la glicosilación. El compuesto se caracteriza por su estructura compleja, que incluye múltiples grupos funcionales que contribuyen a su actividad biológica. La kifunensina ha despertado interés por sus posibles aplicaciones en contextos terapéuticos, particularmente en la investigación del cáncer y el estudio de infecciones virales, donde la glicosilación juega un papel significativo en las interacciones patógeno-huésped. Además, sus propiedades únicas la convierten en un tema de interés en el campo de la química medicinal, donde comprender su mecanismo de acción podría llevar al desarrollo de nuevos agentes terapéuticos.
Fórmula:C8H12N2O6
InChI:InChI=1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
Clave InChI:InChIKey=OIURYJWYVIAOCW-PQMKYFCFSA-N
SMILES:C(O)[C@H]1N2[C@@]([C@@H](O)[C@@H](O)[C@@H]1O)(NC(=O)C2=O)[H]
Sinónimos:- (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)hexahydroimidazo[1,2-a]pyridine-2,3-dione
- (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)imidazo[1,2-a]pyridine-2,3-dione
- Fr 900494
- Imidazo[1,2-a]pyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R,6R,7S,8R,8aS)-
- Imidazo[1,2-a]pyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, [5R-(5α,6β,7α,8α,8aα)]-
- Kifunensine
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Encontrado 9 productos.
Kifunensine-13C2 ,15N
CAS:Producto controladoApplications Kifunensine-13C2 ,15N, is the labeled analogue of Kifunensine (K450000), which is a potent inhibitor of the mannosidase I enzyme and is primarily used in cell culture to make high mannose glycoproteins. References Iwami, M., et al.: J. Antibiotic., 40, 612 (1987); Elbein, A.D., et al.: J. Biol. Chem., 265, 15599 (1990); Elbein, A.D., et al.: Archives of Biochem & Biophys., 288, 1, 177 (1991); Kayakiri, H., et al.: Chem. Pharm. Bull., 39(6), 1378 (1991);Fórmula:C2C6H1215NNO6Forma y color:NeatPeso molecular:235.169Imidazo[1,2-a]pyridine-2,3-dione,hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R,6R,7S,8R,8aS)-
CAS:Fórmula:C8H12N2O6Pureza:98%Forma y color:SolidPeso molecular:232.1907Kifunensine - Bio-X ™
CAS:Kifunensine is a small molecule inhibitor that was designed and synthesized to inhibit plant and animal α-mannosidase I. It is a potent and specific inhibitor with IC50 in nanomolar range. It inhibits the enzyme isoforms in Golgi apparatus (GMI) and endoplasmatic reticulum (ERMI). The compound prevents mannose trimming on glycoproteins and shifts the glycoform content from complex to oligomannose type. Used for the production of recombinant therapeutic glycoproteins with mannose rich N-linked glycans. Kifunensine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C8H12N2O6Pureza:Min. 95%Forma y color:White PowderPeso molecular:232.19 g/molKifunensine
CAS:Potent and specific inhibitor of plant and animal α-mannosidase I with IC50 in nanomolar range. It inhibits the enzyme isoforms in Golgi apparatus (GMI) and endoplasmatic reticulum (ERMI). The compound prevents mannose trimming on glycoproteins and shifts the glycoform content from complex to oligomannose type. Used for the production of recombinant therapeutic glycoproteins with mannose rich N-linked glycans.Fórmula:C8H12N2O6Pureza:Min. 99 Area-%Forma y color:PowderPeso molecular:232.19 g/molKifunensine
CAS:Producto controladoStability Desiccate and Store at -20°C Applications Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.Ph References Iwami, M., et al.: J. Antibiotic., 40, 612 (1987); Elbein, A.D., et al.: J. Biol. Chem., 265, 15599 (1990); Elbein, A.D., et al.: Archives of Biochem & Biophys., 288, 1, 177 (1991); Kayakiri, H., et al.: Chem. Pharm. Bull., 39(6), 1378 (1991)Fórmula:C8H12N2O6Forma y color:White To Off-WhitePeso molecular:232.19
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