CAS 1115-70-4: Clorhidrato de metformina
Descripción:
Clorhidrato de metformina es un agente antihiperglucémico oral utilizado principalmente en el manejo de la diabetes mellitus tipo 2. Pertenece a la clase de medicamentos biguanidas y funciona disminuyendo la producción hepática de glucosa, mejorando la sensibilidad a la insulina y mejorando la captación y utilización periférica de glucosa. La sustancia aparece como un polvo cristalino blanco a blanco amarillento, que es soluble en agua pero tiene una solubilidad limitada en disolventes orgánicos. Su fórmula química es C4H11N5·HCl, y tiene un peso molecular de aproximadamente 165.63 g/mol. Clorhidrato de metformina se administra típicamente en forma de tabletas y es conocido por su favorable perfil de seguridad, siendo los efectos secundarios gastrointestinales los más comunes. También se asocia con un bajo riesgo de hipoglucemia cuando se usa solo. Además, investigaciones han indicado beneficios potenciales más allá del control glucémico, incluyendo protección cardiovascular y manejo del peso. Al igual que con cualquier medicamento, es esencial usar metformina bajo supervisión médica, considerando contraindicaciones e interacciones potenciales con otros medicamentos.
Fórmula:C4H11N5·ClH
InChI:InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
Clave InChI:InChIKey=OETHQSJEHLVLGH-UHFFFAOYSA-N
SMILES:C(NC(=N)N)(N(C)C)=N.Cl
Sinónimos:- 1,1-Dimethylbiguanide Hydrochloride
- 3-(Diaminomethylidene)-1,1-Dimethylguanidine Hydrochloride (1:1)
- Apo-Metformin
- Apophage
- Benofomin
- Biguanide, 1,1-dimethyl-, hydrochloride
- Biguanide, 1,1-dimethyl-, monohydrochloride
- Dabex
- Denkaform
- Dextin
- Diabefagos
- Ver más sinónimos
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METFORMIN HYDROCHLORIDE CRS
CAS:METFORMIN HYDROCHLORIDE CRSFórmula:C4H12ClN5Forma y color:PowderPeso molecular:165.6246Metformin hydrochloride
CAS:Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) is an AMPK activator. Metformin is used in type 2 diabetes research. Cost-effective and quality-assured.Fórmula:C4H12ClN5Pureza:97.53% - 99.00%Forma y color:White Or Almost White Crystals Solid CrystallinePeso molecular:165.63Metformin hydrochloride, EP grade
CAS:Fórmula:C4H11N5·HClPureza:98.5 - 101.0 % (dried substance)Forma y color:White or almost white crystalsPeso molecular:165.62N1,N1-Dimethylbiguanide hydrochloride
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:165.63000488281251,1-Dimethylbiguanide hydrochloride, 97%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C4H12ClN5Pureza:97%Forma y color:Crystalline powder, WhitePeso molecular:165.63Metformin HCl - Bio-X ™
CAS:Metformin is a widely used anti-hyperglycemic (anti-diabetic) agent for the treatment of type 2 diabetes mellitus. This is due to it decreasing blood glucose by decreasing hepatic glucose product by activation of the AMP-activated protein kinase AMPK. Studies have also demonstrated Metformin to have anti-cancer activity, attributed to several mechanisms such as inhibition of mammalian target of rapamycin (mTOR), cancer stem cells and inflammation. Metformin HCl is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C4H11N5•HClPureza:Min. 95%Forma y color:PowderPeso molecular:165.62 g/mol1,1-Dimethylbiguanide hydrochloride
CAS:1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C4H12ClN5Forma y color:White, Crystalline powderPeso molecular:165.63Metformin Hydrochloride
CAS:Fórmula:C4H11N5·HClPureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:165.63Metformin Hydrochloride
CAS:Producto controladoApplications An oral hypoglycemic agent. Slows electron transport in the oxidation pathway in mitochondria. Has been reported to reverse Lupus symptoms in mice in conjunction with 2-deoxy-d-glucose (D239000). Metformin is a well-known type 2 diabetes treatment. Research shows that metformin may inhibit tumor growth both directly and indirectly. Studies indicate that metformin modulates the biology of aging. Metformin blocks the conversion of select substrates into glucose in a redox-dependent manner. References Tucker, G.T., et al.: Brit. J. Clin. Pharmacol., 12, 235 (1981), DeFronzo, R.A., et al.: N. Engl. J. Med., 333, 541 (1995); Chem. and Eng. News, page 7, Feb. 23 (2015); Nir Barzilai et al., Cell Metabolism 23: 1060 June 14 (2016); Chem. and Eng. News, page 7, Feb. 23 (2015); Chem. and Eng. News, page 12, July 30 (2018)Fórmula:C4H11N5·ClHForma y color:WhitePeso molecular:165.62Metformin hydrochloride
CAS:Metformin hydrochlorideFórmula:C4H12N5ClPureza:100%Forma y color:WhitePeso molecular:165.62571,1-Dimethylbiguanide hydrochloride
CAS:1,1-Dimethylbiguanide hydrochlorideFórmula:C4H11N5·ClHPureza:96% (Typical Value in Batch COA)Forma y color: white solidPeso molecular:165.62g/molMetformin HCl
CAS:Metformin is a widely used anti-hyperglycemic (anti-diabetic) agent for the treatment of type 2 diabetes mellitus. This is due to it decreasing blood glucose by decreasing hepatic glucose product by activation of the AMP-activated protein kinase AMPK. Studies have also demonstrated Metformin to have anti-cancer activity, attributed to several mechanisms such as inhibition of mammalian target of rapamycin (mTOR), cancer stem cells and inflammation.Fórmula:C4H12ClN5Forma y color:White PowderPeso molecular:165.62 g/molMetformin hydrochloride
CAS:Fórmula:C4H11N5·HClPureza:(Titration) 98.0 - 102.0 % (dried basis)Forma y color:White or almost white crystalline powderPeso molecular:165.62Metformin hydrochloride (mM/ml)
CAS:Fórmula:C4H12ClN5Pureza:98%Forma y color:SolidPeso molecular:165.6246
