CAS 112022-83-0: (R)-2-Metil-CBS-oxazaborolidina
Descripción:
(R)-2-Metil-CBS-oxazaborolidina es un compuesto organoboro quiral que sirve como catalizador en varias reacciones de síntesis asimétrica, particularmente en la formación de enlaces carbono-carbono. Este compuesto presenta un átomo de boro coordinado a un marco de oxazaborolidina, lo que contribuye a su reactividad y selectividad únicas en catálisis. La presencia del grupo metilo en la posición 2 mejora sus propiedades estéricas y electrónicas, haciéndolo efectivo para reacciones enantioselectivas. Su naturaleza quiral le permite favorecer preferentemente la formación de un enantiómero sobre otro, lo cual es crucial en la síntesis de productos farmacéuticos y otros productos químicos finos. El compuesto se utiliza típicamente en reacciones como la reducción de cetonas y aldehídos, donde puede facilitar la formación de alcoholes con un alto exceso enantiómero. Además, (R)-2-Metil-CBS-oxazaborolidina es valorado por su estabilidad y facilidad de manejo, lo que lo convierte en una opción popular en la química orgánica sintética. Sus aplicaciones se extienden a varios campos, incluida la química medicinal y la ciencia de materiales, donde la quiralidad juega un papel significativo en las propiedades y actividades de los compuestos resultantes.
Fórmula:C18H20BNO
InChI:InChI=1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m1/s1
Clave InChI:InChIKey=VMKAFJQFKBASMU-QGZVFWFLSA-N
SMILES:CB1OC([C@@]2(N1CCC2)[H])(C3=CC=CC=C3)C4=CC=CC=C4
Sinónimos:- (3AR)-1-methyl-3,3-diphenyl-3a,4,5,6-tetrahydropyrrolo[1,2-c][1,3,2]oxazaborole
- (3aR)-1-methyl-3,3-diphenyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole
- (3aR)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole
- (R)-(+)-2-Methyl-CBS-oxazaborolindine
- (R)-1-Methyl,3,3-Diphenyl-TETRAHYDRO-PYRROLO(1,2-C)(1,3,2)oxazaborole
- (R)-1-Methyl-3,3-diphenylhexahydropyrrolo[1,2-c]-[1,3,2]oxazaborole
- (R)-3,3-Diphenyl-1-MethylTETRAHYDRO-1H,3H-PYRROLO[1,2-C][1,3,2]oxazaborole
- (R)-3,3-Diphenyl-1-MethylTETRAHYDRO-3H-PYRROLO-[1,2-C][1,3,2]oxazaborole
- (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
- (R)-5,5-Diphenyl-2-Methyl-3,4-PROPANO-1,3,2-oxazaborolidine
- (R)-Me-CBS
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Encontrado 11 productos.
(R)-(+)-2-Methyl-CBS-oxazaborolidine, 1M solution in toluene
CAS:Producto controladoThis Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H20BNOForma y color:Solution, Colorless to amberPeso molecular:277.17(R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole
CAS:Fórmula:C18H20BNOPureza:98%Forma y color:LiquidPeso molecular:277.1685(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 1mol/L in Toluene
CAS:(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 1mol/L in ToluenePureza:0.97Forma y color:SolutionPeso molecular:277.17g/mol(R)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene
CAS:(R)-2-Methyl-CBS-oxazaborolidine is used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2 symmetrical ferrocenyl diols, and propargyl alcohols. It is also used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone. It is useful in the production of stereospecific motifs such as α-hydroxy acids, α-amino acids, symmetrical ferrocenyl diols and propargyl alcohols. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H20BNOForma y color:Clear colorless to pale yellow, LiquidPeso molecular:277.17(R) -2-Methyl-CBS-oxazaborolidine - 1M solution in Toluene
CAS:(R) -2-Methyl-CBS-oxazaborolidine is a chiral, optically pure 2-methyl-CBS oxazaborolidine. It has been used as a reagent for the stereoselective synthesis of aldehydes. The (R)-2-methyl CBS-oxazaborolidine is prepared by the reaction of the corresponding boronic acid with hydrocyanic acid in toluene. The (S)-2-methyl CBS-oxazaborolidine can be obtained from the reaction of (S)-CBS with hydrocyanic acid in toluene. A high yield of product is obtained from this reaction, and it is an efficient way to synthesize aldehydes such as maxacalcitol, which are not readily available commercially.Fórmula:C18H20BNOPureza:Min. 95%Forma y color:Colourless To Yellow LiquidPeso molecular:277.17 g/molRef: 3D-FM45785
Producto descatalogado(R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine
CAS:Fórmula:C18H20BNOPureza:>97.0%(T)Forma y color:White to Almost white powder to crystalPeso molecular:277.17CALLERY™ (R)-Methyl oxazaborolidine, 1M in toluene
CAS:(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 0.9-1.1M in toluene [(R)-Methyloxazaborolidine] (R)-CBS CatalystFórmula:C18H20BNOForma y color:colorless to amber liq.Peso molecular:277.17(R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine (ca. 1mol/L in Toluene)
CAS:Fórmula:C18H20BNOForma y color:Colorless to Light yellow clear liquidPeso molecular:277.17(R)-(+)-2-Methyl-CBS-oxazaborolidine
CAS:(R)-(+)-2-Methyl-CBS-oxazaborolidine is a dpp-iv inhibitor that is a β-unsaturated ketone. It has been shown to inhibit the enzyme histone lysine demethylase, which may be involved in the regulation of bone mass. This compound also has a pharmacokinetic profile that is characterized by high oral bioavailability, low plasma protein binding, and rapid metabolism by liver enzymes. The reaction mechanism for this compound is based on the formation of an enolate carbanion. (R)-(+)-2-Methyl-CBS-oxazaborolidine can be synthesized with high stereoselectivity and yields from reactions with simple starting materials. This synthetic route also has a number of advantages over other methods: it does not require any protecting groups, it does not use toxic solvents such as dichloromethane or chloroform, and it can be performed in anhydrous conditionsFórmula:C18H20BNOPureza:Min. 95%Forma y color:SolidPeso molecular:277.17 g/mol(R)-Methyl oxazaborolidine 1M in toluene
CAS:Pureza:95.0%Forma y color:Liquid, ClearPeso molecular:369.32000732421875(R)-(+)-2-Methyl-CBS-oxazaborolidine, 1M solution in toluene, AcroSeal™
CAS:Producto controladoThis Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H20BNOForma y color:Liquid, Colorless to amberPeso molecular:277.17
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