CAS: 1179330-52-9

SPR741 is an antimicrobial potentiator, which is derived from polymyxin B, an antibiotic sourced from the bacterium *Bacillus polymyxa*. Its mode of action involves permeabilizing the outer membrane of Gram-negative bacteria, allowing otherwise impermeable antibiotics to enter the bacterial cell. This potentiation effect significantly enhances the efficacy of co-administered antibiotics against resistant strains. SPR741's primary use is in combination with other antibiotics to combat multi-drug resistant Gram-negative bacterial infections. By disrupting the integrity of the bacterial outer membrane, SPR741 facilitates the uptake of companion antibiotics that would typically be ineffective against resistant bacteria. This mechanism is particularly important in addressing the rising threat of antibiotic resistance, offering a promising approach to restore the activity of existing antibiotics. Scientists are exploring its applications in treating various infections where standard treatments have failed, focusing on safety and efficacy through clinical studies.

SPR741, a cationic peptide from polymyxin B, is being developed to treat serious Gram-negative infections.